全文获取类型
收费全文 | 6182篇 |
免费 | 268篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 101篇 |
儿科学 | 168篇 |
妇产科学 | 258篇 |
基础医学 | 646篇 |
口腔科学 | 83篇 |
临床医学 | 435篇 |
内科学 | 1668篇 |
皮肤病学 | 93篇 |
神经病学 | 773篇 |
特种医学 | 202篇 |
外科学 | 875篇 |
综合类 | 28篇 |
一般理论 | 2篇 |
预防医学 | 242篇 |
眼科学 | 162篇 |
药学 | 291篇 |
中国医学 | 22篇 |
肿瘤学 | 446篇 |
出版年
2023年 | 54篇 |
2022年 | 105篇 |
2021年 | 179篇 |
2020年 | 109篇 |
2019年 | 132篇 |
2018年 | 179篇 |
2017年 | 129篇 |
2016年 | 143篇 |
2015年 | 163篇 |
2014年 | 241篇 |
2013年 | 296篇 |
2012年 | 465篇 |
2011年 | 422篇 |
2010年 | 270篇 |
2009年 | 259篇 |
2008年 | 410篇 |
2007年 | 358篇 |
2006年 | 329篇 |
2005年 | 366篇 |
2004年 | 296篇 |
2003年 | 273篇 |
2002年 | 264篇 |
2001年 | 96篇 |
2000年 | 91篇 |
1999年 | 87篇 |
1998年 | 59篇 |
1997年 | 32篇 |
1996年 | 40篇 |
1995年 | 47篇 |
1994年 | 34篇 |
1993年 | 22篇 |
1992年 | 56篇 |
1991年 | 49篇 |
1990年 | 39篇 |
1989年 | 44篇 |
1988年 | 38篇 |
1987年 | 31篇 |
1986年 | 29篇 |
1985年 | 32篇 |
1984年 | 29篇 |
1983年 | 21篇 |
1982年 | 11篇 |
1981年 | 15篇 |
1980年 | 17篇 |
1979年 | 15篇 |
1978年 | 9篇 |
1974年 | 16篇 |
1973年 | 10篇 |
1971年 | 8篇 |
1970年 | 12篇 |
排序方式: 共有6495条查询结果,搜索用时 0 毫秒
1.
2.
Giuseppina Di Stefano Luigi Fiume Michele Baglioni Corrado Busi Pasquale Chieco Felix Kratz Alessandro Mattioli 《European journal of pharmaceutical sciences》2007,30(2):136-142
Several attempts have been made to enhance doxorubicin (DOXO) concentrations in tumour cells by drug conjugation with human albumin (HSA). HSA-DOXO has the drawback of causing DOXO accumulation in spleen and bone marrow, with a consequent leucopoenia not produced when lactose molecules are coupled to the carrier protein. In the present experiments we demonstrated that the effect of HSA lactosamination is not a consequence of a more rapid disappearance from the bloodstream of the lactosaminated conjugate (L-HSA-DOXO), which is rapidly internalized by the liver through the asialoglycoprotein receptor, but is due to a hindered uptake by spleen and bone marrow cells caused by the coupled lactose molecules. Experiments in vitro showed that HSA-DOXO produced an inhibition of murine macrophage proliferation not caused by L-HSA-DOXO. This result can be explained by higher amounts of the former conjugate entering in these cells and suggests macrophages as the cell type responsible for the spleen and bone marrow internalization of HSA-DOXO hindered by lactose coupling. Importantly, lactosamination of HSA did not reduce the marked uptake of HSA-DOXO by chemically induced rat hepatocellular carcinoma. L-HSA-DOXO, by avoiding DOXO accumulation in bone marrow is an attractive candidate for clinical trials against tumors which were found to actively internalize this conjugate in laboratory animals, such as hepatocellular carcinoma. 相似文献
3.
Pasquale Mastroroberto Massimo Chello Francesco Onorati Attilio Renzulli 《European journal of cardio-thoracic surgery》2005,27(3):531-2; author reply 532
4.
M. L. Garrè V. Capra E. Di Battista L. Giampietri P. Nozza A. Raso A. Pezzolo A. Rossi C. Milanaccio M. Pavanello A. Naselli 《Child's nervous system》2007,23(2):219-223
Objects Genetic syndromes associated with ependymoma are uncommon, with the exception of NF2. We describe two cases of ependymoma
presenting with Klinefelter’s Syndrome (KS) as co-morbid condition.
Materials and methods The first patient was diagnosed for KS during pregnancy; he also presented a thyroid agenesis and a deficit of methyltetrahydrofolate
reductase (MTHFR); at 30 months of age he was operated on for a grade II ependymoma of IV ventricle; after a multiple-stage
surgery, he underwent oral chemotherapy and stereotactic radiotherapy, but after 15 months he presented a local recurrence
and died. The second patient was diagnosed for KS at the age of 16 months; at 10 years of age, due to back pain, he underwent
an MRI, which showed a cauda equine tumor. He underwent surgery and radiotherapy. Histology was of mixopapillary ependymoma.
Conclusion In a review of literature, various neoplasms have been described in association with KS. To our knowledge, these are the first
two cases reported of ependymoma associated to KS. A retrospective study of 44 monoinstitutional ependymoma cases demonstrated
association with genetic syndromes in 22%. 相似文献
5.
6.
7.
Giuseppe Montalto Leonardo Ficano Antonio Carroccio Francesco D''arpa Luigi Greco Maurizio Soresi Pasquale Salvo 《Journal of Hepato-Biliary-Pancreatic Surgery》1994,1(5):573-577
The clinical and biochemical presentation of carcinoma of the pancreas (PC) and of the papilla of Vater (CPV) are very similar, and, consequently, detailed investigations are required to correctly distinguish between them. The aim of the present study was to select the clinical and biochemical variables that would most efficiently discriminate the precise site of tumor origin. The study group consisted of 72 patients with PC and 22 patients with CPV consecutively hospitalized in our department. The following clinical parameters were considered: age, asthenia, anorexia, vomiting, weight loss, pain, fever, pruritis, and constipation; the biochemical parameters considered were total, direct, and indirect bilirubin, glucose, alkaline phosphatase, gamma glutamy transferase, transaminase, total protein, amylase, and occult blood in stools. The results indicated that in the initial phase of PC the most frequent clinical parameters were weight loss (P<0.0001), anorexia (P<0.02), constipation (P<0.001), and pruritus (P<0.01). In contrast, in CPV, fever (P<0.003) was most frequent in the same phase. There was a statistically significant difference in occult blood in stools (P<0.0001), total (P<0.03) and direct bilirubin (P<0.02), alkaline phosphatase (P<0.05), and transaminase (P<0.002) values in the two groups. On discriminant analysis, weight loss, constipation, pruritus, nausea, anorexia, and fever were the variables which best discriminated between the two types of tumors. In fact, the presence of weight loss, anorexia, asthenia, constipation, and pruritus correctly classified 87.5% of the patients with PC, while the presence of fever and nausea correctly classified 72.7% of the patients with CPV. 相似文献
8.
R Bassan P E Cornelli R Battista F Terzi M Buelli A Rambaldi P Viero A D'Emilio E Dini T Barbui 《Hematological oncology》1992,10(2):105-110
Twenty-three patients (16 adults) failing their first or subsequent (n = 8) intensive treatment for de novo acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia lymphoid blast phase (n = 2) were managed with protocol POG 8201, originally introduced in relapsed ALL of childhood. In this programme, a four-drug induction phase is followed by early consolidation with teniposide-cytarabine, intrathecal chemotherapy, continuation weekly chemotherapy alternating teniposide-cytarabine with vincristine-cyclophosphamide, and periodic reinduction courses. Fourteen adults and five children with ALL achieved a complete response (CR) (86 per cent). The highest response rate (100 per cent) was obtained in 12 patients treated at first relapse after an initial CR of greater than 18 months (p = 0.07). Median duration of CR was 8 months in adults and 11 months in children. A longer than previous one CR (inversion) was obtained in four cases. Four ALL patients were successfully transplanted from a matched sibling after 3-11 months from achievement of CR. Median overall survival in adults with ALL was 11 months, significantly longer than for 40 comparable cases treated intensively but without rotational continuation therapy in previous years (p less than 0.001). This regimen is applicable to adults with relapsed ALL, where prolongation of survival may allow time for effective salvage with bone marrow transplantation. 相似文献
9.
Bruno Zappacosta Silvia Persichilli Donata Scribano Angelo Minucci Daniele Lazzaro Pasquale De Sole Bruno Giardina 《Clinical chemistry and laboratory medicine》2002,40(11):1139-1142
Slightly elevated values of homocysteine are commonly associated with thromboembolic diseases, while high values can be found in patients with congenital metabolic defects or nutritional problems. The clinical use of homocysteine as an independent marker of cardiovascular disease was limited in the past by technical problems with its measurement, the instrumentation (HPLC, radioenzymatic assays, gas chromatography-mass spectrometry, etc.) and the necessary skills required. Commercially available immunoassays now permit a simpler and more rapid measurement of homocysteine, that is more suitable for routine clinical laboratories; in this paper we analyze the results obtained by using three fully automated methods for homocysteine determination (Abbott IMx immunoassay, Abbott AxSYM immunoassay and Immulite 2000 homocysteine immunoassay) and their correlation with the widely used HPLC method. The results clearly indicate that all three automated immunochemical methods correlate well with the HPLC method (slope 0.97-1.03; intercept 0.95-1.91 with a recovery above 95% for all three methods). 相似文献
10.