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Low-artifact intravascular devices: MR imaging evaluation 总被引:2,自引:0,他引:2
Teitelbaum GP; Ortega HV; Vinitski S; Stern H; Tsuruda JS; Mitchell DG; Rifkin MD; Bradley WG Jr 《Radiology》1988,168(3):713-719
Flow-phantom magnetic resonance (MR) imaging, with use of both spin-echo (SE) and gradient-echo (GRE) techniques at 1.5 T, was performed on the percutaneous Greenfield (beta-III titanium alloy [TMA wire]), Amplatz (MP32-N alloy), and Simon nitinol filters and TMA wire facsimiles of the bird's nest, Gunther, new retrievable, and Amplatz vena caval filters. SE imaging allowed detection of thrombi as small as 5 X 5 mm trapped within the percutaneous Greenfield, Simon nitinol, and TMA-wire facsimile filters; with the MP32-N Amplatz filter, a larger volume of thrombus (10 X 20-mm clots) was necessary for clot detection. GRE imaging allowed detection of intraluminal tilting of the percutaneous Greenfield and facsimile Amplatz (TMA-wire) filters. GRE imaging was useful for demonstrating postfilter turbulence due to clots, which was greatest for the Amplatz filter. Imaging of facsimile vascular devices made of tantalum or TMA wire did not cause the severe "black-hole" MR artifacts typical of the stainless-steel devices. SE and GRE imaging were very useful for determining caval patency in two patients with previously placed Mobin-Uddin filters. Noninvasive MR evaluation of blood vessels in the presence of a variety of low-artifact intravascular devices appears feasible. 相似文献
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Variability of skin temperature in the waking monkey 总被引:3,自引:0,他引:3
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Chang HJ Batts KP Lloyd RV Sebo TJ Thompson GB Lohse CM Pankratz SV 《Endocrine pathology》2000,11(3):229-241
Nonfunctioning islet cell tumors or pancreatic endocrine tumors are the most common type of malignant islet cell tumor. Although
previously detected usually at an advanced stage because of mass effect, the early detection rate of small localized disease
has been increasing. To date it has been difficult to predict the clinical behavior in localized regional nonfunctioning tumors.
To investigate potential markers predicting malignancy and poor prognosis in nonfunctioning pancreatic endocrine tumors, we
analyzed the expression of Ki-67, topoisomerase IIα (Topollα), and p27, as well as a variety of clinicopathologic parameters
in 76 cases of nonfunctioning islet cell tumors (23 benign cases and 53 malignant cases). Ki-67, Topollα, and p27 labeling
indices were significantly different between benign and malignant tumors. Expression of Ki-67, Topollα, and p27 were associated
with survival in patients with a malignant tumor in a univariate setting. However, only p27 and Topollα were jointly associated
with survival in multivariate analysis. Immunohistochemical staining for p27, Topollα, and Ki-67 can be helpful in the diagnosis
of nonfunctioning pancreatic endocrine tumor. Analysis of p27 and Topollα may also have potential utility as prognostic factors
for malignant tumors. 相似文献
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Extinction of the human leukocyte antigen homozygosity effect after two doses of the measles-mumps-rubella vaccine 总被引:1,自引:0,他引:1
St Sauver JL Dhiman N Ovsyannikova IG Jacobson RM Vierkant RA Pankratz VS Jacobsen SJ Poland GA 《Human immunology》2005,66(7):788-798
We have reported associations between human leukocyte antigen (HLA) homozygosity and low measles antibody levels after one dose of the measles, mumps, and rubella (MMR) vaccine. Here, we examined associations between HLA homozygosity and immune responses to MMR after two doses of vaccine. We examined associations between HLA homozygosity and measles antibody levels in a group of 178 children (cohort 1) as well as associations between homozygosity and antibody levels and lymphoproliferative responses to MMR in 346 children (cohort 2). In cohort 1, HLA homozygotes and heterozygotes had similar increases in measles antibody levels after a second dose of measles vaccine. In cohort 2, HLA homozygosity was not associated with measles immune measures after two doses of vaccine. Homozygosity at the DPB locus was associated with increased rubella antibody levels, and homozygosity at the class IA alleles was associated with lower mumps lymphoproliferative response. Homozygosity at increasing numbers of loci was also associated with lower mumps antibody levels and lymphoproliferative response. Therefore, two doses of the MMR vaccine appear to induce sufficient antibody levels and lymphoproliferative responses against measles and rubella, regardless of HLA homozygosity status. However, children who are HLA homozygous may be less protected against mumps compared with children who are heterozygous. 相似文献
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Joseph P Broderick Laura R Sauerbeck Tatiana Foroud John Huston Nathan Pankratz Irene Meissner Robert D Brown 《BMC medical genetics》2005,6(1):17