全文获取类型
收费全文 | 3524篇 |
免费 | 180篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 25篇 |
妇产科学 | 31篇 |
基础医学 | 354篇 |
口腔科学 | 88篇 |
临床医学 | 267篇 |
内科学 | 1000篇 |
皮肤病学 | 235篇 |
神经病学 | 211篇 |
特种医学 | 170篇 |
外科学 | 549篇 |
综合类 | 11篇 |
预防医学 | 125篇 |
眼科学 | 26篇 |
药学 | 328篇 |
中国医学 | 17篇 |
肿瘤学 | 249篇 |
出版年
2023年 | 18篇 |
2022年 | 51篇 |
2021年 | 80篇 |
2020年 | 46篇 |
2019年 | 50篇 |
2018年 | 78篇 |
2017年 | 74篇 |
2016年 | 73篇 |
2015年 | 66篇 |
2014年 | 93篇 |
2013年 | 95篇 |
2012年 | 184篇 |
2011年 | 165篇 |
2010年 | 104篇 |
2009年 | 86篇 |
2008年 | 164篇 |
2007年 | 168篇 |
2006年 | 142篇 |
2005年 | 133篇 |
2004年 | 137篇 |
2003年 | 112篇 |
2002年 | 126篇 |
2001年 | 127篇 |
2000年 | 135篇 |
1999年 | 99篇 |
1998年 | 26篇 |
1997年 | 31篇 |
1996年 | 22篇 |
1995年 | 18篇 |
1994年 | 22篇 |
1993年 | 20篇 |
1992年 | 98篇 |
1991年 | 73篇 |
1990年 | 62篇 |
1989年 | 80篇 |
1988年 | 75篇 |
1987年 | 51篇 |
1986年 | 63篇 |
1985年 | 64篇 |
1984年 | 45篇 |
1983年 | 36篇 |
1979年 | 35篇 |
1975年 | 23篇 |
1974年 | 22篇 |
1973年 | 23篇 |
1970年 | 20篇 |
1969年 | 21篇 |
1968年 | 18篇 |
1967年 | 17篇 |
1966年 | 20篇 |
排序方式: 共有3717条查询结果,搜索用时 0 毫秒
1.
2.
3.
Toshiaki Otsuka Tomoyuki Kawada Masao Katsumata Chikao Ibuki Yoshiki Kusama 《Hypertension research》2007,30(12):1211-1218
The second derivative of the finger photoplethysmogram (SDPTG) has been used as a non-invasive examination for arterial stiffness. The present study sought to elucidate independent determinants of the SDPTG among various cardiovascular risk factors in middle-aged Japanese men. The SDPTG was obtained from the cuticle of the left-hand forefinger in 973 male workers (mean age: 44+/-6 years) during a medical checkup at a company. The SDPTG indices (b/a and d/a) were calculated from the height of the wave components. Multiple logistic regression analyses revealed that the independent determinants of an increased b/a (highest quartile of the b/a) were age (odds ratio [OR]: 1.12 per 1-year increase, 95% confidence interval [CI]: 1.09-1.15), hypertension (OR: 1.65, 95% CI: 1.03-2.65), dyslipidemia (OR: 1.51, 95% CI: 1.09-2.09), impaired fasting glucose/diabetes mellitus (OR: 2.43, 95% CI: 1.16-5.07), and a lack of regular exercise (OR: 2.00, 95% CI: 1.29-3.08). Similarly, independent determinants of a decreased d/a (lowest quartile of the d/a) were age (OR: 1.11 per 1-year increase, 95% CI: 1.08-1.14), hypertension (OR: 3.44, 95% CI: 2.20-5.38), and alcohol intake 6 or 7 days per week (OR: 2.70, 95% CI: 1.80-4.06). No independent association was observed between the SDPTG indices and blood leukocyte count or serum C-reactive protein levels. In conclusion, the SDPTG indices reflect arterial properties affected by several cardiovascular risk factors in middle-aged Japanese men. The association between inflammation and the SDPTG should be evaluated in further studies. 相似文献
4.
5.
In 9 severe head injuries whose respiration was controlled by a ventilator, continuous measurements of energy expenditure (MEE) were carried out by the ERICA Metabolic Computer. Age was ranged 19 to 69 years old (Mean 48.3 years). Glasgow Coma Scale score was 3 to 11 which were assessed the best score during 6 hours of admission. The MEE was carried out within 7 days of admission and was continued to measure more than 3 days. It measured O2 consumption and CO2 output, and calculated the indirect energy expenditure. The data were displayed and recorded every 1, 15, 60 min. The value of MEE was compared with predicted energy expenditure (PEE) which was calculated by the Harris-Benedict formula. Out of 9 patients, 6 patients were survived. High dose barbiturate therapy was performed in 7 patients to control and decrease the intracranial hypertension. Of them 3 patients died. The value of MEE in all 9 patients was variable from 77% to 212% of PEE. The value of MEE in 6 survived patients was 98.0 to 212.0% of PEE. Out of 6 patients, 4 patients who were administered high dose barbiturate showed variable data of MEE. Two patients showed about 100% of the PEE, one showed about 150%, and another one about 200%. Remaining 2 survivors who were not administered barbiturate showed about 125% of PEE, which was low value. These results were divided into two groups. In 2 patients, the value of MEE was 150% or more in spite of barbiturate therapy. In remaining 7 patients, the value of MEE was 125% or less of PEE.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
6.
Male Fischer 344 rats were fed either fiber-free (FF), continuous 10% wheat bran (CWB) or intermittent 50% wheat bran (IWB) diets for 6 wk to investigate possible alterations in physiological effects associated with colon cancer (fecal bulk, transit time, colonic cell proliferation) induced by meal distribution of the bran. The FF and CWB groups consumed unvaried diets throughout the day. The IWB group consumed two consecutive meals of a 50% bran diet for a total of 4 hr each day followed by a fiber-free diet for the remaining hours of the day. Similar daily quantities of bran were consumed in the CWB and IWB groups. Dry fecal weights rose significantly and transit times declined in both bran-fed groups independent of the meal distribution of bran. Colonic cell proliferation (estimated by thymidine kinase activity) was similar in all groups. The results suggest that these physiological effects of wheat bran are independent of the meal distribution of the bran. 相似文献
7.
Mitsuhiko Yanagisawa Rumiko Hosoki Masanori Otsuka 《European journal of pharmacology》1992,220(2-3):111-117
We have developed an isolated spinal cord-skin preparation of the newborn rat. The spinal cord together with a piece of skin connected to the cord by the saphenous nerve was isolated from 1- to 4-day-old rats and separately superfused with artificial cerebrospinal fluid in two neighbouring chambers. Potentials were recorded extracellularly from the third lumbar ventral root. Application of capsaicin (0.5-2 μM) or KCl (60–350 mM) with brief pressure pulses to the perfusion bath of the skin evoked a depolarizing response of 20- to 40-s duration in the ventral root. The response was depressed by [Met5]enkcphalin (0.03–3 μM). morphine (0.1–2 μM) and a tachykinin antagonist, [D-Arg1,D-Trp7,9,Leu11] substance P (spantide), 1–10 μM), applied to the spinal cord by superfusion, whereas the response was augmented by centrally administered calcitonin gene-related peptide (0.1–0.2 μM) or bicuculline (0.5–1 μM). 相似文献
8.
Biodegradation of polydioxanone in bone tissue: effect on the epiphyseal plate in immature rabbits. 总被引:1,自引:0,他引:1
Implants of polydioxanone (PDS), 1.3 mm in diameter, were operatively fixed in the juxta-epiphyseal area of the right proximal tibial metaphysis in six rabbits and were driven into a drill hole of equal bore through the right proximal tibial epiphyseal plate in ten rabbits. The PDS implants had biodegraded almost completely in cortical bone at 16 weeks without any significant sign of inflammation or foreign body reaction. The PDS implants did not cause any growth disturbance. Histologic studies, however, showed that seven of 10 rabbits demonstrated significant osseous bridge formation across the epiphyseal plate. 相似文献
9.
Initial and midterm results for repair of aortic diseases with handmade stent grafts. 总被引:2,自引:0,他引:2
Seiji Onitsuka Atsuhisa Tanaka Hidetoshi Akashi Keiichi Akaiwa Hiroyuki Otsuka Hiroko Yokokura Shigeaki Aoyagi 《Circulation journal》2006,70(6):726-732
BACKGROUND: The purpose of this study was to determine the initial and midterm results for repair of thoracic and abdominal aortic diseases using handmade stent-grafts (SGs). METHODS AND RESULTS: Between 1999 and 2004, 41 consecutive patients (31 patients with thoracic and 10 patients with abdominal aortic disease) underwent endovascular stent-graft repair using handmade SGs. The follow-up averaged 24.8+/-17.6 months. The technical and initial clinical success rates were 82.9% (34/41) and 80.5% (33/41), respectively. Primary type I or III endoleaks occurred in 12.2% (5/41) of the patients. The hospital mortality rate was 4.9% (2/41). Persistent type I or III endoleaks occurred in 9.8% (4/41) and SG migrations occurred in 4.9% (2/41) of the patients. Open surgical conversion was undertaken in 12.2% (5/41) of the patients because of an endoleak and/or migration. The mean change observed in the aneurysm diameter was -6.2+/-10.5 mm, and shrinkage in the diameter occurred in 51.4% (18/35) of the cases. There was 1 patient death because of aneurysm rupture. Neither stent fracture nor graft hole was observed. The overall clinical success rate during follow-up was 78.0% (32/41). CONCLUSION: The initial and midterm results obtained after repair of the aortic diseases using handmade SGs were considered to be satisfactory. More surgical experience and long-term patient follow-up are both required to further reassess the effect of this treatment. 相似文献
10.