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Dunckley T Huentelman MJ Craig DW Pearson JV Szelinger S Joshipura K Halperin RF Stamper C Jensen KR Letizia D Hesterlee SE Pestronk A Levine T Bertorini T Graves MC Mozaffar T Jackson CE Bosch P McVey A Dick A Barohn R Lomen-Hoerth C Rosenfeld J O'connor DT Zhang K Crook R Ryberg H Hutton M Katz J Simpson EP Mitsumoto H Bowser R Miller RG Appel SH Stephan DA 《The New England journal of medicine》2007,357(8):775-788
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Rolf Sobottke Marc Röllinghoff Keta Zarghooni Kourosh Zarghooni Klaus Schlüter-Brust Karl-Stefan Delank Harald Seifert Thomas Zweig Peer Eysel 《Archives of orthopaedic and trauma surgery》2010,130(9):1083-1091
Introduction
Focusing on spondylodiscitis in elderly patients current literature does not contain much information. 相似文献5.
Webster JA Myers AJ Pearson JV Craig DW Hu-Lince D Coon KD Zismann VL Beach T Leung D Bryden L Halperin RF Marlowe L Kaleem M Huentelman MJ Joshipura K Walker D Heward CB Ravid R Rogers J Papassotiropoulos A Hardy J Reiman EM Stephan DA 《Neuro-degenerative diseases》2008,5(2):60-64
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (APOE) epsilon4 allele. Alleles of the APOE gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval. 相似文献
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The study objective was to assess the widespread applicability of ST/HR slope for the modified Bruce exercise test using a computerized electrocardiogram (ECG); compare the usefulness of the ST/HR slope with standard ECG criteria in detection of coronary artery disease (CAD) and identification of three-vessel or left main CAD; and then develop a new, modified ST/HR score (MSHS) for improving the diagnostic accuracy of ST/HR slope. The studies were retrospective and prospective in design, conducted in referral-based cardiology clinics at a national cardiovascular center. A selected sample of 142 patients underwent exercise ECG and coronary angiography, as did a normal control group of 402 patients who were apparently free from CAD. Sixty three other patients who underwent coronary angiography were also studied prospectively. No limitations of medical treatment were exacted for the test except digitalis treatment. Linear regression analysis, from which ST/HR slope was derived, was done with seven measurements of HR and ST displacement at 60 ms from J point in leads a VF and V5 during 6 min before the end of exercise. MSHS was derived from a multiple regression model with peak HR (% maximum HR), ST index (ST depression + ST slope), and ST/HR slope. Although the usual ST criteria (sensitivity = 63 percent, specificity = 73 percent), ST index (71 percent, 80 percent), and ST/HR slope (70 percent, 97 percent) were equally accurate in detection of CAD, MSHS showed significantly improved sensitivity (88 percent) with similar specificity (81 percent). In identification of three-vessel or left main CAD, when compared with other criteria, ST/HR slope and MSHS provided improved diagnostic accuracy: sensitivity (74 and 78 percent, respectively), specificity (88 and 93 percent) and overall test accuracy (85 and 89 percent). The improved accuracy of ST/HR slope and MSHS was prospectively validated in 63 other patients. ST/HR slope was applicable to computerized ECG data for the standard treadmill test, and showed improved accuracy in detection of three-vessel or left main CAD. The new, modified ST/HR score more accurately predicted not only the presence but also the severity of CAD. 相似文献