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1.
Ofer Binah Irit Rubinstein Arieh Bomzon Ori S. Better 《Naunyn-Schmiedeberg's archives of pharmacology》1987,335(2):160-165
Summary The effects of sodium salts of various bile acids on the contractile force and the electrophysiological properties of rat ventricular muscle were studied in vitro. Primary, conjugated, and secondary bile acids were studied in a concentration range of 10–9–10–6 mol/l, which corresponds to concentrations found in the plasm of patients with cholestatic jaundice. In general, the bile acid induced a negative inotropic effect which was manifested as a reduction in active tension, maximum rate of tension activation, and maximum rate of tension relaxation. Twitch duration and time to peak tension were unaffected by the bile acids. The negative inotropism was associated with a reduction in ventricular action potential duration. Resting potential, action potential amplitude, and maximum upstroke velocity of phase 0 depolarization were unaffected. Voltage clamp experiments in rat ventricular myocytes demonstrated that sodium taurocholate decreased the slow inward current and slightly increased the outward potassium current. Hence, these effects on the membrane currents are probably responsible for the negative inotropic effect.
Send offprint requests to O. Binah at the above address 相似文献
2.
The 55-kD bactericidal/permeability-increasing protein (BPI) is a neutrophil-derived polypeptide belonging to a family of
lipid and endotoxin binding proteins. BPI is composed of two functionally distinct structural domains: a potently antibacterial
and antiendotoxin ∼ 20-kD aminoterminal half, and an opsonic carboxy-terminal portion. In multiple animal models, a recombinant
amino-terminal fragment of BPI (rBPI21) is nontoxic and protects against gram-negative bacteria and endotoxin. In humans, rBPI21 is also nontoxic and nonimmunogenic and has undergone phase II/III clinical trials with apparent therapeutic benefit. 相似文献
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4.
Ofer Gemer Benjamin Piura Shmuel Segal Ilana Yanai Inbar 《International journal of gynecological pathology》2003,22(4):398-400
Chondroid syringoma of the vulva is an extremely rare tumor. Of the previously reported cases, only one was clinically malignant. The authors describe a case of chondroid syringoma of the right labium majus from which arose a papillary adenocarcinoma. A right inguinal lymph node was replaced with metastatic adenocarcinoma. 相似文献
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6.
A case report of epithelioid adrenal angiosarcoma is presented. Tumor cells showed expression of cytokeratin, Factor VIII-related antigen, Ulex europaeus agglutinin-I, and vimentin. The patient also was found to have mesenteric fibromatosis (abdominal desmoid tumor) and an elevated serum level of estradiol. The authors discuss the unique appearance of these rare tumors, their relationship to hyperestrinism, and review the recent data in the literature showing cytokeratin expression by malignant epithelioid vascular tumors. 相似文献
7.
PURPOSE: Two studies are presented here. Study 1 was aimed at evaluating whether the voice characteristics of women who use birth control pills that contain different progestins differ from the voice characteristics of a control group. Study 2 presents a meta-analysis that combined the results of Study 1 with those from 3 recent studies that compared voices of women who use and do not use birth control pills. METHOD: In Study 1, voice samples from 30 women with no history of voice training, who use pills with different progestins (drospirenone, desogestrel, gestodene), and 10 women who do not use the pill were recorded at specific time points across the menstrual cycle and were analyzed acoustically. In Study 2, results from Study 1 were analyzed jointly with results from three recent studies, which used similar methodologies. RESULTS: Results of Study 1 did not reveal acoustic differences in sustained phonation of vowels across the pill groups and controls. Results of the meta-analysis performed in Study 2 indicated that pill users exhibited lower jitter and shimmer values on sustained vowels, whereas no difference of fundamental frequency was observed among women who use the pill. CONCLUSIONS: These results support findings from previous studies, which suggested that no adverse effect on voice was detected among nonprofessional speakers who use new-generation monophasic birth control pills, for the measures studied. Furthermore, results of the meta-analysis suggested that some acoustic properties of the voice, which are reflected in perturbation measures in sustained vowels, may be improved among women who use the pill. 相似文献
8.
Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression 总被引:2,自引:0,他引:2
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Sela U Ganor S Hecht I Brill A Miron T Rabinkov A Wilchek M Mirelman D Lider O Hershkoviz R 《Immunology》2004,111(4):391-399
Allicin, a major ingredient of fresh garlic extract that is produced during the crushing of garlic cloves, exerts various beneficial biological effects, including a broad spectrum of antimicrobial activity, antihyperlipidaemic and antihypertensive effects. However, how allicin affects the immune system is less well known, and its effect on human T cells has never been studied. Here, we examined the in-vitro effects of allicin on the functioning of T cells related to their entry to inflamed extravascular sites. We found that allicin (20-100 microm) inhibits the SDF-1alpha (CXCL12)-induced T cell migration through fibronectin (FN), and that this inhibition is mediated by the down-regulation of (i) the reorganization of cortical actin and the subsequent T cell polarization, and (ii) T cell adhesion to FN. Moreover, allicin also inhibited T cell adhesion to endothelial cells and transendothelial migration. The mechanisms underlying these inhibitory effects of allicin are associated with its ability to down-regulate the phosphorylation of Pyk2, an intracellular member of the focal adhesion kinases, and to reduce the expression of the VCAM-1- and FN-specific alpha4beta1-integrin (VLA-4). The ability of allicin to down-regulate these chemokine-induced and VLA-4-mediated T cell functions explains its beneficial biological effects in processes where T cells play an important role and suggests that allicin may be used therapeutically with chronic inflammatory diseases. 相似文献
9.
Alon Peled Ofer Sarig Guangping Sun Liat Samuelov Chi A. Ma Yuan Zhang Tom Dimaggio Celeste G. Nelson Kelly D. Stone Alexandra F. Freeman Liron Malki Lucia Seminario Vidal Latha M. Chamarthy Valeria Briskin Janan Mohamad Mor Pavlovsky Jolan E. Walter Joshua D. Milner Eli Sprecher 《The Journal of allergy and clinical immunology》2019,143(1):173-181.e10
10.
Bareket Falk Ruth Burstein Isaack Ashkenazi Ofer Spilberg Jacob Alter Ester Zylber-Katz Ardon Rubinstein Nava Bashan Yair Shapiro 《European journal of applied physiology》1989,59(3):168-173
Summary The purpose of this study was to determine the effect of caffeine ingestion on physical performance after prolonged endurance
exercise. Twenty three trained male volunteers participated in a 40-km march and were divided into two groups, matched for
caffeine clearance rate and aerobic capacity. The experimental group ingested, prior to the march, a caffeinated drink at
a dose of 5 mg·kg−1 body mass and at the 3rd and 5th h of marching an additional drink at a dose of 2.5 mg·kg−1 body mass. The control group ingested a drink of equal volume at the same times. Upon termination of the march each subject
performed a cycle ergometer test at an intensity of 90% maximal oxygen consumption. Time to exhaustion and rate of perceived
exertion (RPE) were recorded. Blood samples were drawn predrink, at the 3rd and 5th h of marching and immediately after the
cycle ergometer test, and were analysed for caffeine, free fatty acids (FFA), lactate and glucose levels. Plasma FFA levels
increased during the march (p<0.05), with no significant difference between groups. Lactate levels increased in the experimental group (p<0.05), with no significant change in the control group. Glucose levels did not change significantly in either group. After
the cycle ergometer test, lactate levels were significantly higher in the experimental, as compared to the control group (3.77±0.33
vs 2.52±0.35 mmol·l−1, respectively). There was no significant difference between treatments in the time to exhaustion on the cycle ergometer,
but RPE was different (p<0.05). Under the conditions of this study, the results do not indicate caffeine ingestion as an ergogenic aid which will
postpone exhaustion following prolonged endurance exercise.
This work was presented, in part, at the Canadian Association of Sports Sciences Annual Meeting, October 1987, Lake Louise,
Alberta, Canada 相似文献