全文获取类型
收费全文 | 249篇 |
免费 | 9篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 6篇 |
基础医学 | 66篇 |
口腔科学 | 1篇 |
临床医学 | 33篇 |
内科学 | 43篇 |
皮肤病学 | 12篇 |
神经病学 | 5篇 |
特种医学 | 1篇 |
外科学 | 22篇 |
预防医学 | 16篇 |
药学 | 19篇 |
肿瘤学 | 29篇 |
出版年
2022年 | 3篇 |
2021年 | 5篇 |
2019年 | 4篇 |
2018年 | 6篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 5篇 |
2014年 | 8篇 |
2013年 | 8篇 |
2012年 | 13篇 |
2011年 | 12篇 |
2010年 | 8篇 |
2009年 | 7篇 |
2008年 | 6篇 |
2007年 | 5篇 |
2005年 | 2篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2002年 | 7篇 |
2001年 | 5篇 |
1999年 | 5篇 |
1998年 | 2篇 |
1996年 | 2篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 8篇 |
1990年 | 9篇 |
1989年 | 7篇 |
1988年 | 6篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 10篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1974年 | 6篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 7篇 |
1970年 | 4篇 |
1969年 | 4篇 |
1968年 | 6篇 |
1967年 | 3篇 |
1966年 | 3篇 |
1960年 | 1篇 |
排序方式: 共有258条查询结果,搜索用时 78 毫秒
1.
2.
3.
A. A. Nikiforova A. A. Kuz'min W. Richter 《Bulletin of experimental biology and medicine》1995,120(3):962-964
In vitro experiments show that sodium citrate in a final concentration of 130 mM induces a 4- to 5-fold increase in the activity of
lecithin-cholesterol acyltransferase. A parallel determination of the blood content of primary products of lipid peroxidation
reveals a 20–30% decrease in diene and triene conjugates and lipid hydroperoxides.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 323–325, September, 1995
Presented by A. N. Klimov, Member of the Russian Academy of Medical Sciences 相似文献
4.
N. V. Nikiforova V. I. Kirpatovskii E. A. Sevryukov 《Bulletin of experimental biology and medicine》1993,115(3):256-257
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N
o
3, pp. 245–247, March, 1993 相似文献
5.
Omelchenko M. A. Atadzhykova Yu. A. Migalina V. V. Nikiforova I. Yu. Kaleda V. G. 《Neuroscience and behavioral physiology》2022,52(3):330-335
Neuroscience and Behavioral Physiology - Objectives. To identify the clinical and pathopsychological features of juvenile depression with attenuated schizophrenia spectrum symptoms, as well as... 相似文献
6.
Arun A. Mavanur Vamsi Parimi Mark O’Malley Marina Nikiforova David L. Bartlett Jon M. Davison 《International journal of experimental pathology》2010,91(4):357-367
We describe the clinical, pathologic and molecular characteristics of a xenograft model of metastatic mucinous appendiceal adenocarcinoma. Tumours from patients with mucinous appendiceal neoplasms were implanted in nude mice and observed for evidence of intraperitoneal tumour growth. Morphologic and immunohistochemical features, temporal growth characteristics relative to controls, and loss of heterozygosity (LOH) at multiple chromosomal alleles were assessed in a successfully engrafted tumour. Two of seventeen implanted tumours successfully engrafted and only one mucinous adenocarcinoma propagated throughout the course of the study. The successful xenograft is morphologically similar to the original tumour, produces abundant extracellular mucin and exhibits non‐invasive growth on peritoneal surfaces. The temporal growth characteristics of the xenograft tumour relative to controls reveal that tumour burden can be followed indirectly by measuring the weight or abdominal girth of engrafted animals. The cytokeratin, mucin core protein, CDX2, Ki‐67 and p53 expression patterns are identical in the xenograft and resected tumour and are consistent with the expected pattern of protein expression for mucinous adenocarcinoma of the appendix. LOH was found in 1 of 10 informative chromosomal loci (chromosome 10p23) in xenograft tumour cells. Although we were unable to engraft a low‐grade appendiceal mucinous neoplasm, the engrafted adenocarcinoma will be useful for future evaluation of novel therapeutic strategies directed at mucinous appendiceal adenocarcinoma and evaluation of strategies for treating widespread, bulky, mucinous peritoneal surface neoplasms. Xenograft tumour enrichment can facilitate molecular studies of appendiceal epithelial neoplasia. 相似文献
7.
8.
9.
10.
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer 总被引:10,自引:0,他引:10
下载免费PDF全文
![点击此处可从《The Journal of clinical investigation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ciampi R Knauf JA Kerler R Gandhi M Zhu Z Nikiforova MN Rabes HM Fagin JA Nikiforov YE 《The Journal of clinical investigation》2005,115(1):94-101
Genes crucial for cancer development can be mutated via various mechanisms, which may reflect the nature of the mutagen. In thyroid papillary carcinomas, mutations of genes coding for effectors along the MAPK pathway are central for transformation. BRAF point mutation is most common in sporadic tumors. By contrast, radiation-induced tumors are associated with paracentric inversions activating the receptor tyrosine kinases RET and NTRK1. We report here a rearrangement of BRAF via paracentric inversion of chromosome 7q resulting in an in-frame fusion between exons 1-8 of the AKAP9 gene and exons 9-18 of BRAF. The fusion protein contains the protein kinase domain and lacks the autoinhibitory N-terminal portion of BRAF. It has elevated kinase activity and transforms NIH3T3 cells, which provides evidence, for the first time to our knowledge, of in vivo activation of an intracellular effector along the MAPK pathway by recombination. The AKAP9-BRAF fusion was preferentially found in radiation-induced papillary carcinomas developing after a short latency, whereas BRAF point mutations were absent in this group. These data indicate that in thyroid cancer, radiation activates components of the MAPK pathway primarily through chromosomal paracentric inversions, whereas in sporadic forms of the disease, effectors along the same pathway are activated predominantly by point mutations. 相似文献