首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   713篇
  免费   38篇
  国内免费   5篇
儿科学   21篇
妇产科学   27篇
基础医学   88篇
口腔科学   4篇
临床医学   43篇
内科学   161篇
皮肤病学   27篇
神经病学   43篇
特种医学   6篇
外科学   94篇
综合类   1篇
预防医学   76篇
眼科学   15篇
药学   86篇
肿瘤学   64篇
  2023年   8篇
  2022年   21篇
  2021年   38篇
  2020年   21篇
  2019年   23篇
  2018年   22篇
  2017年   13篇
  2016年   22篇
  2015年   32篇
  2014年   41篇
  2013年   37篇
  2012年   58篇
  2011年   52篇
  2010年   24篇
  2009年   36篇
  2008年   35篇
  2007年   52篇
  2006年   34篇
  2005年   35篇
  2004年   32篇
  2003年   40篇
  2002年   24篇
  2001年   5篇
  2000年   8篇
  1999年   4篇
  1998年   8篇
  1997年   6篇
  1996年   1篇
  1995年   3篇
  1992年   5篇
  1991年   3篇
  1990年   2篇
  1988年   3篇
  1987年   2篇
  1986年   1篇
  1985年   2篇
  1984年   1篇
  1976年   1篇
  1941年   1篇
排序方式: 共有756条查询结果,搜索用时 31 毫秒
1.
We review the association between surgically resolvable aortic disease and horseshoe kidney with a discussion of diagnostic problems and therapeutic options.Male patient 81 years of age with horseshoe kidney and an abdominal aortic aneurysm that was discovered by chance in an abdominal ultrasound during a check-up for his prostate condition.A retroperitoneal approach was used in order to resect the aneurysm and perform an aorto-aortic bypass with no complications occurring. Two years after the diagnosis, the patient is still asymptomatic from a vascular point of view.The co-presence of horseshoe kidney and aortic disease needing surgical correction is infrequent, but it significantly increases the technical complexity of aortic reconstruction. A literature review is included.  相似文献   
2.
BACKGROUND: Pilonidal disease is a chronic disease of the natal cleft. Recurrent follicular infection is the causative factor. Surgical treatment has a significant failure rate, and recurrence is common. Laser removal of hair in the natal cleft could be an alternative to surgery. OBJECTIVE: To determine the effectiveness of laser hair removal in the natal cleft on pilonidal disease. METHODS: Six young men with recurrent pilonidal disease were treated with laser epilation in our clinic from 2000 to 2003. Most patients had a history of one or more surgical treatments in the area, and all patients had suffered recurrent folliculitis for years. An alexandrite laser was mostly used, although, occasionally, an intense pulsed light device was used. The number of epilation treatments ranged from 3 to 11, performed at 6- to 8-week intervals. RESULTS: All patients experienced progressive resolution of the folliculitis with the laser epilation treatments. No more surgical treatments have been needed. The treatments were simple and quick, and there were no complications. CONCLUSION: Laser epilation of the natal cleft should be considered a first choice treatment for recurrent pilonidal disease. Preventive laser epilation of the natal cleft in patients with recurrent folliculitis could avoid future surgery.  相似文献   
3.
OBJECTIVE: It is not well established whether the blood flow of arterial composite Y-grafts can efficiently respond to the flow demand of the coronary system early postoperatively. The aim of this study was to evaluate if soon after the operation, arterial composite Y-grafts can increase blood flow in response to an increase in myocardial oxygen consumption (MVO2). METHODS: Twenty-seven patients who received complete arterial myocardial revascularization using the left internal thoracic artery (LITA) and the radial artery (RA) as composite Y-graft gave their consent to a pre-discharge coronary angiography and intravascular flow velocity measurements using a Doppler guide wire. Flow measurements were performed in the LITA main stem, the distal LITA and the RA, both at rest and during atrial pacing at the 85% of the patient age-predicted maximum. The heart rate-systolic blood pressure product was considered as an indirect index of MVO2. Hyperemic flow was determined after injection of adenosine. The flow reserve (FR) was defined as the ratio of blood flow during maximal hyperemia (Qmax) to baseline flow (Qbasal). RESULTS: Atrial pacing increased MVO2 significantly (P<0.000). None of the patients developed ischemic S-T segment modifications or complained of chest pain. Q(basal) increased significantly in the LITA main stem (P=0.001), distal LITA (P=0.041) and RA (P=0.004) while Qmax did not change significantly. As a consequence, the FR decreased in the LITA main stem (P=0.002), distal LITA (P<0.000) and RA (P<0.000) but was not completely exhausted. CONCLUSIONS: Soon after the operation, arterial composite Y-grafts can significantly increase blood flow in response to conditions of increased MVO2, keeping normal the myocardial O2 supply-to-demand ratio.  相似文献   
4.
Quality of Life Research - This study aimed to determine predictors of health-related quality of life (HRQoL) in Parkinson's disease (PD) and to explore their predictive value before and after...  相似文献   
5.
Local excision (LE) has arisen as an alternative to total mesorectal excision for the treatment of early rectal cancer. Despite a decreased morbidity, there are still concerns about LE outcomes.This systematic-review and meta-analysis design is based on the “PICO” process, aiming to answer to three questions related to LE as primary treatment for early-rectal cancer, the optimal method for LE, and the potential role for completion treatment in high-risk histology tumors and outcomes of salvage surgery.The results revealed that reported overall survival (OS) and disease-specific survival (DSS) were 71%–91.7% and 80%–94% for LE, in contrast to 92.3%–94.3% and 94.4%–97% for radical surgery. Additional analysis of National Database studies revealed lower OS with LE (HR: 1.26; 95%CI, 1.09–1.45) and DSS (HR: 1.19; 95%CI, 1.01–1.41) after LE. Furthermore, patients receiving LE were significantly more prone develop local recurrence (RR: 3.44, 95%CI, 2.50–4.74). Analysis of available transanal surgical platforms was performed, finding no significant differences among them but reduced local recurrence compared to traditional transanal LE (OR:0.24;95%CI, 0.15–0.4). Finally, we found poor survival outcomes for patients undergoing salvage surgery, favoring completion treatment (chemoradiotherapy or surgery) when high-risk histology is present.In conclusion, LE could be considered adequate provided a full-thickness specimen can be achieved that the patient is informed about risk for potential requirement of completion treatment. Early-rectal cancer cases should be discussed in a multidisciplinary team, and patient's preferences must be considered in the decision-making process.  相似文献   
6.
Inflammatory abdominal aortic aneurysms are known to be associated with retroperitoneal fibrosis and ureteral complications. We report a case of an inflammatory aneurysm that produced bilateral ureteral envelopment and obstructive renal failure. Incidence, pathogenesis and clinical onset of this kind of aneurysms and management of the ureteral complications are reviewed.  相似文献   
7.
8.
BACKGROUND: There is increasing interest in minimally invasive direct coronary artery bypass grafting (MID-CABG); however, there is still little information about midterm results and postoperative quality of life. METHODS: From March 1995 to March 1998, 64 patients underwent MIDCABG at our hospital. Their mean age was 60+/-9.5 years; 22 (34.4%) had unstable angina. All patients were followed-up by both direct visit and questionnaire to assess the postoperative quality of life. RESULTS: There were no perioperative deaths nor conversions to sternotomy; the perioperative myocardial infarction rate was 1/64 (1.6%). Predischarge angiography showed overall and unobstructed patency rates of 96.8% (62 of 64) and 93.8% (60 of 64), respectively. At follow-up (25+/-11.4 months) actuarial survival was 100%, and survival free of myocardial infarction was 98.4%+/-1.6% at 3 years. Both the Physical Activity Score and the Psychological General Well-being Index improved significantly after the operation, with percentage improvements of 31% and 23%, respectively, at 12 months postoperatively. CONCLUSIONS: In selected patients MIDCABG can be a reliable and safe option. Patients who undergo this procedure are free of major complications and enjoy a good quality of life after surgery.  相似文献   
9.
10.
Open in a separate window OBJECTIVESAlthough the intra-aortic balloon pump (IABP) has been the most widely adopted temporary mechanical support device in cardiac surgical patients, its use has declined. The current study aimed to evaluate the occurrence and predictors of early mortality and complication rates in contemporary cardiac surgery patients supported by an IABP.METHODSA multicentre, retrospective analysis was performed of all consecutive cardiac surgical patients receiving perioperative balloon pump support in 8 centres between January 2010 to December 2019. The primary outcome was early mortality, and secondary outcomes were balloon-associated complications. A multivariable binary logistic regression model was applied to evaluate predictors of the primary outcome.RESULTSThe study cohort consisted of 2615 consecutive patients. The median age was 68 years [25th percentile 61, 75th percentile 75 years], with the majority being male (76.9%), and a mean calculated 30-day mortality risk of 10.0%. Early mortality was 12.7% (n = 333), due to cardiac causes (n = 266), neurological causes (=22), balloon-related causes (n = 5) and other causes (n = 40). A composite end point of all vascular complications occurred in 7.2% of patients, and leg ischaemia was observed in 1.3% of patients. The most important predictors of early mortality were peripheral vascular disease [odds ratio (OR) 1.63], postoperative dialysis requirement (OR 10.40) and vascular complications (OR 2.57).CONCLUSIONSThe use of the perioperative IABP proved to be safe and demonstrated relatively low complication rates, particularly for leg ischaemia. As such, we believe that specialists should not be held back to use this widely available treatment in high-risk cardiac surgical patients when indicated.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号