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Nellina Saveriano Michael Drinnan Vivien Santer Dennis G. Osmond 《European journal of immunology》1981,11(11):870-876
Cells from mouse bone marrow, thymus and spleen were exposed to 125I-labeled concanavalin A (Con A), Lens culinaris lectin (LCL), soybean agglutinin (SBA), Helix pomatia agglutinin (HPA), phytohemagglutinin-P (PHA-P), peanut agglutinin (PNA), or wheat germ agglutinin (WGA) in a range of concentrations and examined radioautographically. Small lymphocytes in the three organs differed in the minimal concentration of each lectin which gave detectable surface labeling, while at optimal lectin concentrations, their labeling intensity profiles differed markedly. Inhibition by sugars demonstrated the labeling specificity. Major populations of bone marrow small lymphocytes bound WGA strongly, while Con A, SBA, HPA, PHA-P and LCL were bound only weakly, and PNA binding was lacking. Most thymus cells bound Con A, SBA, HPA, PHA-P and PNA strongly, WGA and LCL weakly. Subsets of bone marrow and thymus small lymphocytes differed from the major populations in their lectin-binding intensities. Spleen small lymphocytes were heterogeneous in the binding of each lectin. However, a major population bound LCL exceptionally strongly, while few cells bound PNA. Using a panel of lectins under standardized conditions, these studies show distinctive lectin-binding patterns for small lymphocytes in the bone marrow, thymus and spleen, respectively. Major and minor cell populations are distinguishable in each organ, providing an approach to discriminating lymphocyte lineages, subtypes and differentiation stages. 相似文献
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Monique Saveriano De Benedetto Caroline Carvalho Morais Tatiane Fernandes Novaes Jonas de Almeida Rodrigues Mariana Minatel Braga Fausto Medeiros Mendes 《Lasers in medical science》2011,26(2):157-162
The aims of this in vitro study were (1) to compare the reliability of a new fluorescence camera (FC; VistaProof) with that
of two other laser fluorescence devices (DIAGNOdent and DIAGNOdent pen) in assessing smooth and occlusal caries lesions in
primary teeth and (2) to determine the influence of the spacer, the protective cover and air drying on the FC readings. We
selected 129 primary molars which were divided into two groups: smooth surfaces (n=68) and occlusal surfaces (n=61). Two trained examiners performed the evaluations using the FC and the other laser fluorescence devices separately. One
examiner repeated all assessments after 1 week. Inter- and intraexaminer reproducibility was calculated from the absolute
values derived from the devices using intraclass correlation coefficient (ICC) and Bland-Altman analysis. Pearson correlation
was performed among the values obtained with the different devices. For aim 2, only teeth from the occlusal surface group
were used. Another examiner performed measurements with the FC, varying the size of the spacer, the use of the plastic protective
cover and the drying time (0, 3 and 15 s). Wilcoxon’s test was used to compare these measurements. High values of interexaminer
ICC were observed with the FC in both experiments. However, the highest intraexaminer ICC for smooth surfaces was found for
the DIAGNOdent (ICC 0.918). A positive correlation between all methods was observed in both studies. Only drying for 15 s
significantly increased the FC readings. In conclusion, the FC showed high reliability for occlusal and smooth surfaces, similar
to the other fluorescence methods tested. Additionally, prolonged air drying increased the FC measurements. 相似文献
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M. Maschio L. Dinapoli F. Saveriano A. Pompili C. M. Carapella A. Vidiri B. Jandolo 《Acta neurologica Scandinavica》2009,120(3):210-212
Background – Zonisamide (ZNS) is an antiepileptic drug (AED) with broad spectrum action that demonstrated a good efficacy in controlling seizures as add‐on in adult and pediatric epilepsy. To date there have been no studies on ZNS in patients with brain tumor‐related epilepsy (BTRE). Aim of the study – To evaluate efficacy and tolerability of ZNS as add‐on in BTRE. Methods– We followed six patients suffering from BTRE who had already been treated with other AEDs and who had had not experienced adequate seizure control. Three patients underwent chemotherapy while being treated with ZNS. Mean duration of follow‐up was 8 months. Results – Mean seizure number in the last month prior to the introduction of ZNS had been 27.7/month. ZNS mean dosage was of 283.3 mg/day. At last follow‐up, the mean seizure number was reduced to 8.8/month. Responder rate was 83.3%.Two patients discontinued the drug because of side effects. There were no other reported side effects. Conclusions – Preliminary data on the use of ZNS in add‐on in patients with BTRE indicate that this drug may represent a valid alternative as add‐on in this particular patient population. However, larger samples are necessary to draw definitive conclusions. 相似文献
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Tatiane Fernandes Novaes Caroline Moraes Moriyama Monique Saveriano De Benedetto Eduardo Kazuo Kohara Mariana Minatel Braga Fausto Medeiros Mendes 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2016,26(1):13-19
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Fausto Medeiros Mendes Monique Saveriano De Benedetto Cristina Giovannetti del Conte Zardetto Marcia Turolla Wanderley Maria Salete Nahás Pires Correa 《Quintessence international, dental digest》2004,35(9):689-692
A case report describing a technique for the restoration of endodontically treated primary maxillary incisors with resin composite short posts and celluloid strip crowns in a 3-year-old boy is presented. The technique offers the advantages of using one restorative material, improving esthetics, and reducing chairtime and costs. 相似文献
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Ronilza Matos Tatiane Fernandes Novaes Alessandra Reyes Monique Saveriano De Benedetto Fausto Medeiros Mendes Mariana Minatel Braga 《Lasers in medical science》2013,28(1):185-192
The aim of this in vitro study was to determine the influence of cross-infection control methods, as probe tip autoclaving and polyvinyl chloride (PVC) wrapping, on the performance of laser fluorescence device (DIAGNOdent pen—LFpen) on occlusal surfaces of primary molars. One experienced examiner carried out all examinations (n?=?78). For the probe tip autoclaving study, 62 sites (sample A, 40 teeth) were used. The sites were assessed with LFpen using tips in six different conditions: without autoclaving and after autoclaving for 10, 20, 30, 40, and 50 cycles of 10 min. For the PVC wrapping study, we selected other 58 sites (sample B, 38 teeth). The sites were assessed with the LFpen device in two conditions: with and without PVC wrapping. The teeth were sectioned and histologically assessed for caries depth. LFpen values, sensitivity, and specificity were compared among the different conditions. The LF readings were slightly higher after successive examinations, independently of autoclaving. In both studies, no statistical differences in the sensitivity and specificity were observed for all conditions. In conclusion, probe tip autoclaving and PVC wrapping do not influence the performance of LFpen device on occlusal surfaces of primary molars. 相似文献