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排序方式: 共有281条查询结果,搜索用时 0 毫秒
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S Iu Ostrovski? B I Gorenshte?n G A Dosta L M Karaedova L I Nefedov 《Farmakologiia i toksikologiia》1990,53(4):63-65
A single administration to rats of cyanamide (60 mg/kg, for 1 hour) was found to decrease the contents of cysteate, serine, glutamate, glycine, alanine, valine, methionine, isoleucine, tyrosine, ethanolamine, ornithine and histidine that may be considered as a manifestation on the drug hepatotoxicity. The activities of transaminases, glutamate dehydrogenase, pyruvate dehydrogenase remained unchanged. Cyanamide effects were considerably abolished by the supplementary ethanol administration (0.5 g/kg). Cyanamide failed to affect vitamin-dependent enzymes reflecting thiamine pyrophosphate, pyridoxal phosphate and flavine adenine dinucleotide status of the rat organism. 相似文献
3.
Razin BV Inzhevatkin EV Nefedova VV Egorova AB Kazbanov VI Nefedov VP 《Bulletin of experimental biology and medicine》2001,131(6):568-569
We studied the effects of cis-dichlorodiammine platinum (II) on different pathways of cell death in cultured Ehrlich ascites carcinoma in vitro and on subsequent growth of transplanted tumor in vivo. One-hour incubation with the cytostatic modulated apoptosis in cell culture. However, exposure of cell culture to a minimal effective concentration of cis-platinum(II)diammine dichloride promoted the growth of transplanted tumor. 相似文献
4.
Yu. G. Nefedov 《Bulletin of experimental biology and medicine》1957,43(1):44-48
Summary Chronaximetric reactions of immune and nonimmune rabbits after injection of lethal doses of toxin differ. Immune animals reveal no essential changes in chronaxy of muscles, nerve, spinal cord and brain when toxin is injected.Nonimmune rabbits reveal a considerable change of chronoxy. Most pronounced changes arise in muscle when tetanus toxin is injected and in the motor zone of the cerebral cortex when botalinus toxin is injected. Changes in chronaxy appear earlier than clinical symptoms of the disease.Submitted by Active Member of the Academy of Medical Sciences of the USSR, Professor G. V. Vygodchikov 相似文献
5.
Inzhevatkin EV Savchenko AA Egorova AB Al'brant AI Nefedov VP 《Bulletin of experimental biology and medicine》2000,129(4):350-351
The metabolic state of rat liver was studiedin vivo 1, 6, and 18 h after single hyperthermia (42°C). It was shown that intracellular compensatory reactions involved in restoration
of the energy state and realization of endogenous cytoprotective mechanisms play a role during recovery.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 414–416, April, 2000 相似文献
6.
V. V. Evdokimov V. I. Erasova V. I. Kirpatovskii V. M. Kodentsova O. A. Vrzhesinskaya N. A. Beketova L. F. Kurilo T. V. Ostroumova L. V. Shileiko I. Yu. Sakharov I. Yu. Nefedov 《Bulletin of experimental biology and medicine》1998,126(6):1221-1223
Reduction in the epididymis weight and in the spermatozoid concentration together with marked morphological changes in the
seminiferous tubules were observed in the progeny of irradiated rats. Vitamin E content in the testes increased 2.8-fold,
while that of vitamin B2 decreased 1.6-fold.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 12, pp. 652–654, December, 1998. 相似文献
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8.
V. A. Gorpinchenko E. A. Yatsynich D. V. Petrov L. T. Karachurina R. Yu. Hisamutdinova N. Zh. Baschenko V. A. Dokichev Yu. V. Tomilov M. S. Yunusov O. M. Nefedov 《Pharmaceutical Chemistry Journal》2005,39(6):289-291
Exo-2-amino-exo-3-aminomethylbicyclo[2.2.1]heptane (I) and 5-amino-exo-3-azatricyclo[5.2.1.02,6]decan-4-one (II) were synthesized and characterized with respect to antiarrhythmic activity. Compound II exhibited antiarrhythmic
activity with ED50 = 0.28 and 0.33 mg/kg on the aconitine and calcium chloride models of arrhythmia, respectively. Compound I did not show antiarrhythmic
activity and exhibited acute toxicity corresponding to LD50 = 450 mg/kg.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 6, pp. 9 – 11, June, 2005. 相似文献
9.
In vivo release and turnover of secreted platelet antiheparin proteins in rhesus monkey (Macaca mulatta) 总被引:1,自引:0,他引:1
Musial J; Niewiarowski S; Edmunds LH Jr; Addonizio VP Jr; Nicolaou KC; Colman RW 《Blood》1980,56(4):596-607
Human and rhesus monkey platelets secrete at least two antiheparin proteins: platelet factor 4 (PF4) and low affinity platelet factor 4 (LA-PF4). Neither of these proteins showed species-related antigenic differences. As determined by radioimmunoassay, the levels of PF4 and LA-PF4 antigen per 10(9) monkey platelets amounted to 10.7 and 20.3 microgram, respectively. One milliliter of monkey plasma prepared from blood collected into an anticoagulant composed of EDTA, prostaglandin E1, and theophylline solution contained 22.4 ng LA-PF4 and 8.0 ng PF4. Concentrations of these two platelet-specific proteins in monkeys closely resembled levels found in human platelets and plasma. Infusion of prostacyclin (PGI2) (100 or 300 ng/kg/min) into monkeys for 15 min resulted in a significant decrease of plasma levels of LA-PF4 antigen and of PF4 by 40%--60% (p < 0.0001). This decrease was related to the inhibitory effect of PGI2 on the secretion of platelets stimulated by a catheter or by venipuncture. Longer infusion of PGI2 did not produce further significant change. The supernate obtained after aggregation of human platelets stimulated by thrombin was injected into monkeys receiving PGI2 infusion. The disappearance of LA-PF4 antigen in monkey plasma followed a biphasic exponential curve with half-lives for the fast and slow components of 8.4 and 63 min. PF4 disappeared faster but followed the same pattern (half-lives for the fast and slow component of 2.1 and 70 min). Analysis of the experimental data suggests that the low levels of secreted platelet proteins in monkey plasma are related to their minimal in vivo release and to their rapid clearance. 相似文献
10.