全文获取类型
收费全文 | 468篇 |
免费 | 44篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 18篇 |
妇产科学 | 8篇 |
基础医学 | 113篇 |
口腔科学 | 1篇 |
临床医学 | 46篇 |
内科学 | 135篇 |
皮肤病学 | 3篇 |
神经病学 | 30篇 |
特种医学 | 7篇 |
外科学 | 41篇 |
综合类 | 4篇 |
预防医学 | 26篇 |
眼科学 | 8篇 |
药学 | 29篇 |
中国医学 | 1篇 |
肿瘤学 | 43篇 |
出版年
2023年 | 11篇 |
2022年 | 20篇 |
2021年 | 39篇 |
2020年 | 11篇 |
2019年 | 17篇 |
2018年 | 19篇 |
2017年 | 22篇 |
2016年 | 18篇 |
2015年 | 18篇 |
2014年 | 28篇 |
2013年 | 28篇 |
2012年 | 44篇 |
2011年 | 36篇 |
2010年 | 22篇 |
2009年 | 18篇 |
2008年 | 36篇 |
2007年 | 29篇 |
2006年 | 30篇 |
2005年 | 16篇 |
2004年 | 16篇 |
2003年 | 7篇 |
2002年 | 9篇 |
2001年 | 1篇 |
1998年 | 3篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1982年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1969年 | 2篇 |
1968年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有515条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
The constitutional gain-of-function variant p.Glu1099Lys in NSD2 is associated with a novel syndrome
Bernt Popp Melanie Brugger Sibylle Poschmann Tobias Bartolomaeus Maximilian Radtke Julia Hentschel Nataliya Di Donato Andreas Rump Janina Gburek-Augustat Elisabeth Graf Matias Wagner Ina Sorge Johannes R Lemke Thomas Meitinger Rami Abou Jamra Vincent Strehlow Theresa Brunet 《Clinical genetics》2023,103(2):226-230
5.
Background
Phosphoinositides mediate one of the intracellular signal transduction pathways and produce a class of second messengers that are involved in the action of hormones and neurotransmitters on target cells. Thyroid hormones are well known regulators of lipid metabolism and modulators of signal transduction in cells. However, little is known about phosphoinositides cycle regulation by thyroid hormones. The present paper deals with phosphoinositides synthesis de novo and acylation in liver at different thyroid status of rats. 相似文献6.
7.
We report a case of acquired thrombotic thrombocytopenic purpura (TTP) in a 34-year old patient with a prior diagnosis of
systemic lupus erythematosis (SLE) who was recently started on hydroxychloroquine. Presenting symptoms included fevers, sore
throat and productive cough with progressive weakness, dyspnea on exertion, hemoptysis and dark urine. Initial laboratory
abnormalities were consistent with an acute microangiopathic hemolytic anemia and severe thrombocytopenia. At the time of
admission, the patient’s lupus was highly active as evident by his high SLE Disease Activity Index (SLEDAI) score. He was
later also found to have severely reduced ADAMTS-13 levels and a positive antibody assay. This case highlights the occasional
difficulty in pinpointing the exact etiology of TTP as well as establishes a possible novel drug association between hydroxychloroquine
and TTP development. 相似文献
8.
9.
10.
Stacy Loeb Shomik Sengupta Mohit Butaney Joseph N. Macaluso Stefan W. Czarniecki Rebecca Robbins R. Scott Braithwaite Lingshan Gao Nataliya Byrne Dawn Walter Aisha Langford 《European urology》2019,75(4):564-567
YouTube is a social media platform with more than 1 billion users and >600 000 videos about prostate cancer. Two small studies examined the quality of prostate cancer videos on YouTube, but did not use validated instruments, examine user interactions, or characterize the spread of misinformation. We performed the largest, most comprehensive examination of prostate cancer information on YouTube to date, including the first 150 videos on screening and treatment. We used the validated DISCERN quality criteria for consumer health information and the Patient Education Materials Assessment Tool, and compared results for user engagement. The videos in our sample had up to 1.3 million views (average 45 223) and the overall quality of information was moderate. More videos described benefits (75%) than harms (53%), and only 50% promoted shared decision-making as recommended in current guidelines. Only 54% of the videos defined medical terms and few provided summaries or references. There was a significant negative correlation between scientific quality and viewer engagement (views/month p = 0.004; thumbs up/views p = 0.015). The comments section underneath some videos contained advertising and peer-to-peer medical advice. A total of 115 videos (77%) contained potentially misinformative and/or biased content within the video or comments section, with a total reach of >6 million viewers.