医学院校护理本科生逆商四维度培养路径的探索

如何提高医学院校护理本科生在应对公共卫生突发事件时逆转困境的能力,是亟待深入研究的问题。通过培养学生的逆商,提高学生逆商水平,是培养这种能力的一种有效的途径。本文阐明了逆商构成的4个维度,分析了护理专业大学生四维逆商形成的因素;提出了将四维逆商培养融入护理专业教育体系中,建立四维逆商水平评价体系和机制的路径;介绍了在护理专业实践教学中,通过倾听和沟通交流培养逆商的方法。     

Synthesis of Well‐Defined Telechelic Macrophotoinitiator of Polystyrene by Combination of ATRP and Click Chemistry

A new well‐defined telechelic macrophotoinitiator of polystyrene was synthesized by combination of ATRP and click chemistry. The ATRP of styrene by means of 2‐oxo‐1,2‐diphenylethyl‐2‐bromopropanoate (PI‐Br) initiator with CuBr/2,2′‐bipyridine yields polystyrene with photoactive benzoin (PI) and bromine (Br) group (PI‐PSt‐Br). Subsequently, PI‐PSt‐Br was converted to PI‐PSt‐N₃ by simple nucleophilic substitution reaction. Alkyne functionalized benzoin (PI‐alkyne) was synthesized by using benzoin photoinitiator and propargyl bromide. Then the coupling reaction between PI‐PSt‐N₃ and PI‐alkyne was performed by Cu(I) catalysis. The spectroscopic studies revealed that low‐polydispersity polystyrene with desired photoinitiator functionality at both end of the chain, PI‐PSt‐PI, was obtained.

     

Synthesis and Characterization of Well‐Defined Mid‐Chain Functional Macrophotoinitiators of Polystyrene by Combination of ATRP and “Click” Chemistry

A combination of ATRP and “click” chemistry is employed for efficient preparation of a novel well‐defined mid‐chain functional macrophotoinitiator of polystyrene. Bromo‐terminated polystyrene (PSt‐Br) is prepared by ATRP of styrene using a methyl‐2‐bromopropanoate initiator with CuBr/PMDETA. Subsequently, PSt‐Br is converted to PSt‐N₃ by a simple nucleophilic substitution reaction. A dialkyne‐functionalized photoinitiator (alkyne‐PI‐alkyne) is synthesized using a dihydroxy‐functional photoinitiator and propargyl bromide. Then the “click” reaction between PSt‐N₃ and alkyne‐PI‐alkyne is performed by Cu(I) catalysis. Spectroscopic studies reveal that low‐polydispersity polystyrene with the desired photoinitiator functionality in the middle of the chain (PSt‐PI‐PSt) is obtained.

     

护理干预联合半导体激光治疗中风后肩手综合征

目的 观察护理干预联合半导体激光治疗中风后肩手综合征患者的临床疗效.方法 2014年1月-2015年12月入住我院针灸四科,并满足相关纳入标准的60例中风后肩手综合征患者作为研究对象.随机分为治疗组和对照组,各30例.2组均给予神经内科及针灸科基础治疗,治疗组在此基础上给予护理干预联合局部半导体激光治疗,20 min/次,1次/d,7次为1个疗程,共治疗2个疗程.观察2组日常生活活动能力(Barthel指数评定)、肿胀程度、疼痛视觉模拟评分(VAS),对治疗效果进行科学评估.结果 治疗前后2组疼痛感、肿胀情况以及肢体运动能力和治疗效果比较差异显著,具有统计学意义(P<0.05),且治疗组优于对照组(P<0.05).结论 护理干预联合半导体激光治疗能够有效的缓解中风后肩手综合征病人的疼痛感、水肿情况,并且使得肢体的运动能力得到了一定的恢复.     

醋酸甲羟孕酮及其片剂中4,5-二氢醋酸甲羟孕酮的HPLC法测定

建立了高效液相色谱法测定醋酸甲羟孕酮中的4,5-二氢醋酸甲羟孕酮。采用C₁₈色谱柱,以甲醇-乙腈-水（30:50:20）为流动相,检测波长285 nm。有关物质4,5-二氢醋酸甲羟孕酮在2～50μg/ml浓度范围内线性关系良好,在原药与片剂中的回收率均为99.2%,RSD为0.9%与1.0%。     

Well‐Defined Cyclohexene Oxide Mid‐Chain Functional Polystyrene Macromonomer: Synthesis,Characterization and Photoinitiated Cationic Homo‐ and Copolymerization

In this article, we present the results of a study of the preparation of a cyclohexene oxide (CHO) mid‐chain functional macromonomer via ATRP of styrene (St) and epoxidation on work‐up with 3‐chloroperoxybenzoic acid. The ATRP initiator, Br? CH? Br, was synthesized by the condensation of 3‐cyclohexene‐1,1‐dimethanol with 2‐bromopropanoyl bromide. The ATRP of St with Br? CH? Br and Cu(I)/bpy yielded well‐defined polystyrene with a cyclohexene mid‐chain group (PSt? CH? PSt). Epoxidation of the PSt? CH? PSt was performed using 3‐chloroperoxybenzoic acid. GPC, IR and ¹H NMR analyses revealed that a low polydispersity macromonomer of polystyrene with CHO functionality at the mid‐chain (PSt? CHO? PSt) was obtained. The photoinduced cationic polymerization of PSt? CHO? PSt yielded comb‐shaped and graft copolymers.

     

硅胶假体隆乳术并发症分析

随着硅胶假体隆乳术的广泛开展，其手术并发症也日趋增多。现就１９８９年以来，所诊治的各种并发症共２４例，包括血肿１例，感染１例，乳头感觉神经损伤２例，乳房位置不对称２例，大小不对称２例，外观畸形３例，纤维包膜挛缩８例，假体破裂１例，窦道形成１例，异常泌乳３例。对发病原因及防治方法进行了讨论。     

利用基因芯片技术检测不同浓度蔗糖条件下变形链球菌差异表达基因

目的:利用基因芯片技术筛选不同浓度蔗糖条件下变形链球菌中差异表达的基因.方法:构建变形链球菌基因表达谱检测芯片,利用基因芯片技术筛选不同浓度蔗糖环境中变形链球菌差异表达的基因,以观察不同浓度蔗糖环境对变形链球菌基因表达的影响.结果:0.5%蔗糖环境相对于1.0%蔗糖环境,变形链球菌中有约40种基因表达发生显著变化,其中与变形链球菌毒力、致病性、信号系统、细菌表面成分、脂肪酸和磷脂代谢和DNA复制、重组、修复等相关的23种基因表达显著下调,而糖转运系统和能量代谢等相关的17种基因表达明显上调(P<0.05).结论:不同浓度蔗糖环境对变形链球菌的调控是多因素、多基因共同作用的结果;基因芯片能有效地筛选不同环境中变形链球菌差异表达的基因.     

可乐丽菲露SE BOND用于直接盖髓术的组织学评价

目的:对可乐丽菲露SEBOND在人体用于直接盖髓术进行组织学评价。方法:选择24名志愿者共45颗健康人第三磨牙,41颗在牙合面制备Ⅰ类洞并在洞底作人工穿髓孔,然后分为2组,实验组以可乐丽菲露SEBOND盖髓,对照组以氢氧化钙盖髓。4颗作为空白对照。所有实验牙齿分别在盖髓后的7、30、90d后拔除并进行组织学检测。结果:实验组和对照组志愿者均未出现术后实验牙齿敏感症状。病理检测显示,在7d和30d的观察期内2组均有轻度到中度的炎性反应,但可乐丽菲露SEBOND组的炎性反应较氢氧化钙组轻,其组织学评价分级上的差别有统计学意义(P<0.05)。在90d的观察期内2组均无明显的炎性反应,而牙本质桥的形成在氢氧化钙组显著多于可乐丽菲露SEBOND组,氢氧化钙组7例标本中有6例标本有牙本质桥的形成,可乐丽菲露SEBOND组7例标本中有3例形成,其差别有统计学意义(P<0.05)。结论:可乐丽菲露SEBOND对牙髓的刺激性较小,但诱导牙本质形成的能力较氢氧化钙弱。