全文获取类型
收费全文 | 281篇 |
免费 | 15篇 |
专业分类
妇产科学 | 4篇 |
基础医学 | 57篇 |
口腔科学 | 6篇 |
临床医学 | 14篇 |
内科学 | 71篇 |
皮肤病学 | 1篇 |
神经病学 | 21篇 |
特种医学 | 19篇 |
外科学 | 73篇 |
预防医学 | 18篇 |
药学 | 2篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 4篇 |
2020年 | 4篇 |
2019年 | 2篇 |
2018年 | 8篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 9篇 |
2014年 | 4篇 |
2013年 | 7篇 |
2012年 | 14篇 |
2011年 | 15篇 |
2010年 | 12篇 |
2009年 | 12篇 |
2008年 | 17篇 |
2007年 | 17篇 |
2006年 | 12篇 |
2005年 | 22篇 |
2004年 | 15篇 |
2003年 | 12篇 |
2002年 | 21篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 11篇 |
1997年 | 10篇 |
1996年 | 4篇 |
1995年 | 11篇 |
1994年 | 6篇 |
1993年 | 6篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 1篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1972年 | 1篇 |
1970年 | 1篇 |
1969年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有296条查询结果,搜索用时 15 毫秒
1.
S. Oh-ishi Takako Kizaki Tomomi Ookawara Koji Toshinai Shukoh Haga Fujio Karasawa Tetsuo Satoh Naokazu Nagata L. L. Ji Hideki Ohno 《Pflügers Archiv : European journal of physiology》1998,435(6):767-774
The aim of the current study was to elucidate the synergism of dietary calcium restriction and exhaustive exercise in the
antioxidant enzyme system of rat soleus muscle, and to investigate the involvement of neutrophils in exercise-induced muscle
damage. Forty-eight male Wistar rats were assigned to the following groups: control (C) or calcium-restricted [1 month (1 M)
or 3 months (3 M)]. Each group was subdivided into acutely exercised or non-exercised groups. Soleus muscle from each rat
was analysed to determine the levels of antioxidant enzymes [Mn-superoxide dismutase (SOD), Cu,Zn-SOD, glutathione peroxidase
(GPX), and catalase (CAT)]. Dietary calcium restriction resulted in calcium deficiency and upregulated the antioxidant enzymes
examined except GPX. Conversely, exhaustive exercise significantly decreased GPX and CAT, but not SODs activities in the calcium-restricted
(1 M and/or 3 M) rats. Contents of immunoreactive Mn-SOD and Cu,Zn-SOD were only increased in the 3 M rats. During calcium
restriction, the mRNA expression of both forms of SOD showed initial upregulation, followed by downregulation. Exhaustive
exercise significantly increased the mRNA expressions only in the 3 M rats. Moreover, exhaustive exercise markedly increased
myeloperoxidase activity in soleus muscles from the 1 M and 3 M rats compared with the C rats, and significantly enhanced
the ability of neutrophils to generate superoxide in the 3 M rats. The results demonstrate that dietary calcium restriction
upregulates certain antioxidant enzyme activities in rat soleus muscle, indicating an enhanced resistance to potential increases
in intracellular reactive oxygen species. The results also suggest that exhaustive exercise may cause oxidative damage in
soleus muscle of calcium-deficient rats through the activation of neutrophils.
Received: 4 August 1997 / Received after revision: 29 September 1997 / Accepted: 26 November 1997 相似文献
2.
Value of percutaneous transhepatic cholangioscopy (PTCS) 总被引:4,自引:0,他引:4
Yuji Nimura Shigehiko Shionoya Naokazu Hayakawa Junichi Kamiya Satoshi Kondo Akihiro Yasui 《Surgical endoscopy》1988,2(4):213-219
Since July 1975, percutaneous transhepatic biliary drainage (PTBD) has been performed in 533 cases, and since April 1977 we have developed percutaneous transhepatic cholangioscopy (PTCS) as a diagnostic and therapeutic endoscopical tool in 198 cases of malignant disease and 195 benign cases. After dilating the sinus tract of PTBD using a 15-Fr catheter about 2 weeks after PTBD, PTCS was carried out through the sinus tract. PTCS has diagnostic advantages: the lesion can be accurately diagnosed histologically and the extent of cancer in the biliary tract can be assessed by taking biopsy specimens before the operation. PTCS has been applied for cholangioscopic lithotripsy in 145 cases of gallstone disease. In 44 cases, the Nd-YAG laser and/or electrohydraulic shock wave has been used to break up the stones. The PTCS morbidity was 6% and mortality was 0.3%. 相似文献
3.
Hideo Yamamoto Naokazu Hayakawa Katsura Hamaguchi Shunichiro Komatsu Masato Nagino Yuji Nimura 《Journal of hepato-biliary-pancreatic sciences》1995,2(2):184-189
A rare case of nonfunctioning islet cell carcinoma associated with tumor thrombi in both the portal and splenic veins is reported. The patient, a 49-year-old male, had a 2-year history of occasional abdominal pain. Computed tomography (CT) disclosed a huge mass in the body of the pancreas, and celiac arteriogram showed a tumor stain in the body and tail of the pancreas. Percutaneous transhepatic portography (PTP) demonstrated an irregular filling defect, indicating intraportal tumor growth. Curative surgery, which included total pancreatectomy with combined resection (50 mm in length) and reconstruction of the portal vein, distal gastrectomy, and partial resection of the transverse colon, was performed. Histological examination of the surgical specimen led to a diagnosis of nonfunctioning islet cell carcinoma with a negative immunohistochemical stain for insulin, glucagon, somatostatin, and adrenocorticotropic hormone. The patient has been well for 38 months to date without any sign of tumor recurrence. Our experience with this case has introduced a radical resection for islet cell tumor of the pancreas, even if the tumor has extended into the portal vein. 相似文献
4.
5.
6.
Ratana Tacharoenmuang Satoshi Komoto Ratigorn Guntapong Sompong Upachai Phakapun Singchai Tomihiko Ide Saori Fukuda Kriangsak Ruchusatsawast Busarawan Sriwantana Masashi Tatsumi Kazushi Motomura Naokazu Takeda Takayuki Murata Somchai Sangkitporn Koki Taniguchi Tetsushi Yoshikawa 《Journal of medical virology》2020,92(2):174-186
Group A rotavirus (RVA) is a major cause of acute gastroenteritis in infants and young children worldwide. This study aims to clarify the distribution of G/P types and genetic characteristics of RVAs circulating in Thailand. Between January 2014 and September 2016, 1867 stool specimens were collected from children and adults with acute gastroenteritis in six provinces in Thailand. RVAs were detected in 514/1867 (27.5%) stool specimens. G1P[8] (44.7%) was the most predominant genotype, followed by G3P[8] (33.7%), G2P[4] (11.5%), G8P[8] (7.0%), and G9P[8] (1.3%). Unusual G3P[9] (0.8%), G3P[10] (0.4%), G4P[6] (0.4%), and G10P[14] (0.2%) were also detected at low frequencies. The predominant genotype, G1P[8] (64.4%), in 2014 decreased to 6.1% in 2016. In contrast, the frequency of G3P[8] markedly increased from 5.5% in 2014 to 65.3% in 2015 and 89.8% in 2016. On polyacrylamide gel electrophoresis, most (135/140; 96.4%) of the G3P[8] strains exhibited a short RNA profile. Successful determination of the nucleotide sequences of the VP7 genes of 98 G3P[8] strains with a short RNA profile showed that they are all equine-like G3P[8] strains. On phylogenetic analysis of genome segments of two representative Thai equine-like G3P[8] strains, it was noteworthy that they possessed distinct NSP4 genes, one bovine-like and the other human-like. Thus, we found that characteristic equine-like G3P[8] strains with a short RNA electropherotype are becoming highly prevalent in children and adults in Thailand. 相似文献
7.
8.
Yuji Nimura Naokazu Hayakawa Junichi Kamiya Satoshi Kondo Masato Nagino Michio Kanai 《Journal of Hepato-Biliary-Pancreatic Surgery》1995,2(3):239-248
We have studied the surgical anatomy of the intrahepatic bile duct, hepatic hilus, and caudate lobe based on intraoperative
findings and selective cholangiography of surgical patients and resected specimens, and have established the cholangiographic
anatomy of the intrahepatic subsegmental bile duct. Thorough knowledge of the three-dimensional anatomy of the subsegmental
bile duct, hepatic hilus, and caudate lobe is indispensable for curative surgery of hilar cholangiocarcinoma. We designed
and actually performed 15 kinds of hepatic segmentectomies with caudate lobectomy and extrahepatic bile buct resection in
100 consecutive patients, with curative resection being possible in 82 patients. Postoperative survival after curative resection
of hilar cholangiocarcinoma was better than expected, and the 5-year survival rates for all 82 patients with curative resection
and for 55 patients with curative surgery without portal vein resection were 31% and 43%, respectively. Hepatic segmentectomy
with caudate lobectomy and extrahepatic bile duct resection should be designed not only in accordance with the preoperative
diagnosis of tumor extension into the intrahepatic bile ducts but also so that curative surgery for advanced hilar cholangiocarcinoma
can be performed. 相似文献
9.
Yamamoto H Hayakawa N Kitagawa Y Katohno Y Sasaya T Takara D Nagino M Nimura Y 《Journal of Hepato-Biliary-Pancreatic Surgery》2005,12(5):391-398
Background/Purpose Many cases have been reported of disastrous port-site recurrence after laparoscopic cholecystectomy (LC) revealed unsuspected
gallbladder carcinoma (GBC). Some investigators have reported that the prognosis of patients after LC showed unsuspected GBC
is not worsened by laparoscopic procedures. We retrospectively reviewed our cases and the literature to reconfirm the intrinsic
risks of LC for unsuspected GBC.
Methods Of 1663 patients who underwent LC from January 1991 to December 2003 in a single institution, 9 (0.54%) with unsuspected GBC
were reviewed.
Results These 9 patients consisted of 5 men and 4 women, whose ages ranged from 58 to 87 years, with a median age of 73 years. Two
patients with a pT1a tumor (limited to mucosa) and 2 patients with a pT1b tumor (muscle layer) underwent no further operation.
The remaining 5 patients with a pT2 tumor (subserosa) underwent further operations with lymph node dissection. Five patients
(2 patients with pT1b and 3 patients with pT2) developed recurrence and all of them died within a median period of 19 months
(range 14–37 months) after LC. The causes of death were bone metastases in 1 patient (pT2), local recurrence in 2 patients
(pT1b and pT2), and peritoneal metastasis in 2 patients (one elderly patient with pT1b who underwent laparoscopic common bile
duct exploration, and one patient with pT2 in whom the cystic duct was damaged during surgery). Four patients (2 with pT1
and 2 with pT2) have been doing well with a median follow-up of 39.5 months (range 12–99 months) after LC.
Conclusions Surgeons should always prevent bile spillage during LC and when removing the resected gallbladder. When laparoscopic common
bile duct exploration is planned, especially for elderly women, surgeons should also bear in mind the increasing possibility
of unsuspected GBC. 相似文献
10.