全文获取类型
收费全文 | 2958篇 |
免费 | 198篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 96篇 |
妇产科学 | 70篇 |
基础医学 | 467篇 |
口腔科学 | 33篇 |
临床医学 | 334篇 |
内科学 | 630篇 |
皮肤病学 | 67篇 |
神经病学 | 257篇 |
特种医学 | 165篇 |
外科学 | 302篇 |
综合类 | 43篇 |
一般理论 | 3篇 |
预防医学 | 225篇 |
眼科学 | 74篇 |
药学 | 196篇 |
1篇 | |
中国医学 | 12篇 |
肿瘤学 | 188篇 |
出版年
2023年 | 8篇 |
2022年 | 36篇 |
2021年 | 58篇 |
2020年 | 37篇 |
2019年 | 71篇 |
2018年 | 69篇 |
2017年 | 44篇 |
2016年 | 49篇 |
2015年 | 54篇 |
2014年 | 85篇 |
2013年 | 131篇 |
2012年 | 174篇 |
2011年 | 175篇 |
2010年 | 116篇 |
2009年 | 118篇 |
2008年 | 163篇 |
2007年 | 209篇 |
2006年 | 181篇 |
2005年 | 172篇 |
2004年 | 170篇 |
2003年 | 137篇 |
2002年 | 163篇 |
2001年 | 24篇 |
2000年 | 21篇 |
1999年 | 21篇 |
1998年 | 60篇 |
1997年 | 66篇 |
1996年 | 51篇 |
1995年 | 35篇 |
1994年 | 38篇 |
1993年 | 33篇 |
1992年 | 16篇 |
1991年 | 17篇 |
1990年 | 18篇 |
1989年 | 28篇 |
1988年 | 32篇 |
1987年 | 23篇 |
1986年 | 12篇 |
1985年 | 18篇 |
1984年 | 21篇 |
1983年 | 19篇 |
1982年 | 19篇 |
1981年 | 29篇 |
1980年 | 18篇 |
1979年 | 10篇 |
1978年 | 13篇 |
1977年 | 7篇 |
1976年 | 10篇 |
1974年 | 7篇 |
1973年 | 9篇 |
排序方式: 共有3178条查询结果,搜索用时 15 毫秒
1.
D Monnier† C Vidal‡ L Martin§ A Danzon¶ F Pelletier† E Puzenat† MP Algros†† D Blanc† R Laurent† PH Humbert† F Aubin† 《Journal of the European Academy of Dermatology and Venereology》2006,20(10):1237-1242
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumour of the skin, with an estimated incidence of 0.8 to five cases per 1 million people per year. OBJECTIVE: To study epidemiological, immunohistochemical and clinical features, delay in diagnosis, type of treatment and outcome of DFSP from 1982 to 2002. METHODS: Using data from the population-based cancer registry, 66 patients with pathologically proved DFSP were included (fibrosarcomatous DFSP were excluded). Each patient lived in one of the four departments of Franche-Comté (overall population of 1 million people) at the time of diagnosis. The main data sources came from public and private pathology laboratories and medical records. The rules of the International Agency for Research on Cancer were applied. RESULTS: The estimated incidence of DFSP in Franche-Comté was about three new cases per 1 million people per year. Male patients were affected 1.2 times as often as female patients were. The trunk (45%) followed by the proximal extremities (38%) were the most frequent locations. DFSP occurred mainly in young adults between 20 and 39 years of age. Mean age at diagnosis was 43 years, and the mean delay in diagnosis was 10.08 years. Our 66 patients initially underwent a radical local excision. Among them, 27% experienced one or more local recurrences during 9.6 years of follow-up. There was one regional lymph node recurrence without visceral metastases. These recurrences were significantly related to the initial peripheral resection margins. We observed a local recurrence rate of 47% for margins less than 3 cm, vs. only 7% for margins ranging from 3 to 5 cm [P=0.004; OR=0.229 (95%, CI=0.103-0.510)]. The mean time to a first local recurrence was 2.65 years. Nevertheless, there was no death due to the DFSP course at the end of the follow-up, and the final outcome was favourable. CONCLUSION: Our study emphasizes the importance of wide local excision with margins of at least 3 cm in order to prevent local recurrence. However, the recent development of inhibitors of signal transduction by the PDGFB pathway should soon modify the surgical strategy, which is often too mutilating. 相似文献
2.
3.
Morphological and biochemical studies of a mouse mutant (fro/fro) with bone fragility. 总被引:4,自引:0,他引:4
The mutation fragilitas ossium (fro) was discovered in a random-bred stock of mice during an experiment aimed at detecting recessive lethal mutations after treatment of the postmeiotic germ cells of male mice with tris (1-aziridinyl)phosphine sulphide. The affected mice were moderately runted and had deformities in all four limbs. The radiological and histological findings indicate that the mutant is similar to human osteogenesis imperfecta. The ash content of long bones was lower in the mutant. A defect of type I collagen could not be detected. The electrophoretic patterns of alpha bands of type I and V collagen and CB derived peptides of type I collagen from bone and skin showed no abnormalities. The total collagen synthesis and secretion in cultures of dermal fibroblasts, as well as the gel electrophoresis of procollagen and collagen chains synthesized, and of their CB peptides, were the same as those found in the controls. The percentage of type I and type V collagen synthesized was similar; that of type III was lower in the mutants. Bone osteonectin was found to be decreased by 30% and bone sialoprotein by 5%. The mRNA level for osteonectin was decreased in the fibroblasts of the mutant by about 50%. Whether the defective expression of the osteonectin in fro/fro mice is due to a mutation in the gene itself or its regulatory site(s), or is secondary to other factors remains to be established. The fro/fro mouse may represent a model for some forms of human bone fragility without collagen abnormalities. 相似文献
4.
5.
Muriel Mitcheson Brown 《British Journal of Psychotherapy》2006,22(4):463-470
ABSTRACT Freud's paper on the Schreber Case is considered from a contemporary perspective drawing on the object relations theorists. Some of Winnicott's ideas are used to illustrate how one might understand Schreber's predicament today. Although Freud's views on the role of repressed homosexual longings in the aetiology of Schreber's illness are not endorsed his prescience in the search for meaning in the patient's discourse is applauded. 相似文献
6.
7.
A 79-year-old man was referred to emergency department for vagueabdominal pain. In the past, the patient had cardiac arrhythmiasnecessitating a pacemaker placement. On admission, the patienthad a normal ausculation and the abdomen examination was unremarkable.Postero-anterior chest radiograph revealed normal cardiac sizeand a small left pleural effusion. 相似文献
8.
Kevin Montgomery Michael Stephanides Stephen Schendel Muriel Ross 《Computerized medical imaging and graphics》2005,29(2-3):203-222
This paper covers work in virtual reality-based, patient-specific surgical planning over the past decade. It aims to comprehensively examine the user interface paradigms and system designs during that period of time and to objectively analyze their effectiveness for the task. The goal is to provide useful feedback on these interface and implementation paradigms to aid other researchers in this field. First, specialized systems for specific clinical use were produced with a limited set of visualization tools. Later, through collaboration with NASA, an immersive virtual environment was created to produce high-fidelity images for surgical simulation, but it underestimated the importance of collaboration. The next system, a networked, distributed virtual environment, provided immersion and collaboration, but the immersive paradigm was found to be of a disadvantage and the uniqueness of the framework unwieldy. A virtual model, workbench-style display was then created using a commercial package, but limitations of each were soon apparent. Finally, a specialized display, with an integrated visualization and simulation system is described and evaluated. Lessons learned include: surgical planning is an abstract process unlike surgical simulation; collaboration is important, as is stereo visualization; and that high-resolution preoperative images from standard viewpoints are desirable, but interaction is truly the key to planning. 相似文献
9.
Over the past decade, the unfortunate reality is that the income gap has widened between Canadian families. Educational outcomes are one of the key areas influenced by family incomes. Children from low-income families often start school already behind their peers who come from more affluent families, as shown in measures of school readiness. The incidence, depth, duration and timing of poverty all influence a child’s educational attainment, along with community characteristics and social networks. However, both Canadian and international interventions have shown that the effects of poverty can be reduced using sustainable interventions. Paediatricians and family doctors have many opportunities to influence readiness for school and educational success in primary care settings. 相似文献
10.
Laboratory investigation: Effects of propofol on the systemic inflammatory response during aortic surgery 总被引:2,自引:0,他引:2
José M. Rodríguez-López Pilar Sánchez-Conde Francisco S. Lozano Juan L. Nicolás Francisco J. García-Criado Carlos Cascajo Clemente Muriel 《Journal canadien d'anesthésie》2006,53(7):701-710
PURPOSE: A laboratory investigation was undertaken to assess the effects of propofol on renal function, through modulation of the systemic inflammatory response, in an in vivo experimental model of aortic surgery in comparison with sevoflurane. METHODS: Twenty young male piglets were anesthetized with either propofol 4 mg.kg(-1).hr(-1) (n = 10) or sevoflurane 1.5% end-tidal concentration (n = 10). Animals were subjected to aorta-aortic bypass with suprarenal aortic clamping for 30 min. At specific intervals (basal -before the start of surgery; reperfusion 15 min after unclamping the aorta; at 24, 48 and 72 hr after surgery, and on the seventh day after surgery) the levels of the following were determined: plasma creatinine, renal myeloperoxidase, tumour necrosis factor-alpha, interleukin 1-ss, and interferon-gamma; kidney superoxide anion and its detoxifying enzyme superoxidase dismutase, kidney malondialdehyde and the activity of inducible nitric oxide synthase. Seven days after surgery, the animals were anesthetized using the described techniques, and after blood withdrawal and kidney sampling they were sacrificed. RESULTS: In comparison with sevoflurane, propofol was associated with a lower concentration of plasma creatinine (P < 0.05) together with lower concentrations of myeloperoxidase, tumour necrosis factor-alpha, interleukin 1-ss, interferon-gamma, superoxide anion and superoxidase dismutase, malondialdehyde and inducible nitric oxide synthase (P < 0.05). CONCLUSION: In an experimental model of aortic reconstructive surgery, and compared with sevoflurane, propofol anesthesia is associated with less neutrophil infiltration, lower plasma proinflammatory cytokine levels, lower production of oxygen free radicals, less lipid peroxidation, and reduced inducible nitric oxide synthase activity. These observations suggest a possible renal protective effect of propofol in this surgical setting. 相似文献