全文获取类型
收费全文 | 909篇 |
免费 | 35篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 44篇 |
妇产科学 | 12篇 |
基础医学 | 77篇 |
口腔科学 | 38篇 |
临床医学 | 70篇 |
内科学 | 243篇 |
皮肤病学 | 115篇 |
神经病学 | 29篇 |
特种医学 | 140篇 |
外科学 | 53篇 |
综合类 | 10篇 |
预防医学 | 14篇 |
眼科学 | 38篇 |
药学 | 36篇 |
1篇 | |
中国医学 | 6篇 |
肿瘤学 | 26篇 |
出版年
2022年 | 6篇 |
2021年 | 9篇 |
2020年 | 7篇 |
2019年 | 9篇 |
2018年 | 12篇 |
2017年 | 6篇 |
2016年 | 4篇 |
2015年 | 7篇 |
2014年 | 18篇 |
2013年 | 24篇 |
2012年 | 32篇 |
2011年 | 36篇 |
2010年 | 29篇 |
2009年 | 30篇 |
2008年 | 35篇 |
2007年 | 33篇 |
2006年 | 43篇 |
2005年 | 31篇 |
2004年 | 23篇 |
2003年 | 32篇 |
2002年 | 15篇 |
2001年 | 20篇 |
2000年 | 19篇 |
1999年 | 13篇 |
1998年 | 34篇 |
1997年 | 28篇 |
1996年 | 42篇 |
1995年 | 37篇 |
1994年 | 34篇 |
1993年 | 21篇 |
1992年 | 10篇 |
1991年 | 19篇 |
1990年 | 6篇 |
1989年 | 29篇 |
1988年 | 33篇 |
1987年 | 20篇 |
1986年 | 18篇 |
1985年 | 19篇 |
1984年 | 16篇 |
1983年 | 12篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 13篇 |
1979年 | 9篇 |
1978年 | 5篇 |
1977年 | 13篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1973年 | 3篇 |
1965年 | 2篇 |
排序方式: 共有953条查询结果,搜索用时 15 毫秒
1.
2.
Eri Inoue-Matsuhisa Sayoko E Moroi Hisashi Takenaka Shunji Sogo Tomiya Mano 《Journal of ocular pharmacology and therapeutics》2003,19(1):55-62
The serotonin 2 (5-HT(2)) receptor antagonists, MCI-9042 (Anplag) and ketanserin, have been shown to lower intraocular pressure in rabbits (1) and humans (2). The mechanism of action of these drugs has not been determined, but it is hypothesized that 5-HT(2) receptors, and possibly alpha-adrenergic receptors, (3) may regulate in part aqueous humor production via an intracellular signal transduction pathway in the ciliary body. We therefore examined whether 5-HT(2) receptors were coupled to phosphoinositide hydrolysis in an organ culture system of isolated bovine ciliary epithelium. 5-HT stimulated [(3)H]inositol phosphates ([(3)H]InsPs) accumulation in a dose-dependent manner with a maximum increase approximately twice over the basal level. The mean EC(50) value was 1.1 microM, which was calculated from four dose-response curves. The 5-HT stimulated accumulation of [(3)H]InsPs was inhibited by spiperone (5-HT(2A/1A) and dopamine 2 (D(2)) antagonists), M-1 (a major metabolite of MCI-9042), ketanserin (5-HT(2A) antagonist), SB-206553 (5- HT(2B/2C) antagonist), and mesulergine (5-HT(2C) antagonist and D(2) agonist). It was not inhibited by chlorpromazine, which is a D(2) receptor antagonist. Accordingly, our study demonstrates that 5-HT(2) receptors are coupled to phospholipase C in bovine ciliary epithelium. 相似文献
3.
Ketai LH; Williamson MR; Telepak RJ; Levy H; Koster FT; Nolte KB; Allen SE 《Radiology》1994,191(3):665
4.
Keisuke Morita MD ; Kazunori Urabe ; Yoichi Moroi ; Tetsuya Koga ; Ryuji Nagai ; Seiko Horiuchi ; Masutaka Furue 《Wound repair and regeneration》2005,13(1):93-101
Advanced glycation end products are the chemical modification of proteins induced by sugars in a hyperglycemic condition. Extracellular matrix proteins are prominent targets of nonenzymatic glycation because of their slow turnover rates. The aim of this study was to investigate the influence of nonenzymatic glycation of type I collagen on the migration of keratinocytes. The migration of keratinocytes was dramatically promoted on native type I collagen-coated dishes compared with that on uncoated dishes. When type I collagen was glycated with glycolaldehyde, large amounts of advanced glycation end products were produced; the glycated collagen I-coated dishes did not promote the migration of keratinocytes. Glycated collagen I did not affect the proliferative capacity of keratinocytes. However, the adhesion of keratinocytes to glycated collagen I was profoundly diminished in a glycation intensity-dependent manner. alpha2beta1 integrin is responsible for the migration and adhesion of keratinocytes to type I collagen. Pretreatment with glycated collagen I did not affect the expression level or functional activity of alpha2beta1 integrin on keratinocytes. These findings suggest that in the presence of glycated collagen I, keratinocytes lose their adhesive and migratory abilities. As the glycation did not modify the alpha2beta1 integrin on keratinocytes, it is suggested that glycation may diminish the binding capacity of type I collagen. 相似文献
5.
Braffman BH; Coleman BG; Ramchandani P; Arger PH; Nodine CF; Dinsmore BJ; Louie A; Betsch SE 《Radiology》1994,190(3):797
6.
Kinnison ML; Perler BA; Kaufman SL; Mitchell SE; Kadir S; Williams GM; White RI Jr 《Radiology》1986,160(3):727-730
In situ saphenous vein grafts are being used with increasing frequency for bypass procedures involving the femoral and popliteal arteries. Complications of these procedures include anastomotic stenoses and persistent arteriovenous fistulae that may result in failure of the graft. Balloon angioplasty and embolotherapy with detachable balloons were employed successfully in three or four recent cases of patients with complications from in situ grafts. Tailored angiography is essential for evaluating in situ grafts, and interventional techniques are extremely useful for managing complications. 相似文献
7.
8.
Intestinal schistosomiasis japonica: CT-pathologic correlation 总被引:1,自引:0,他引:1
Lee RC; Chiang JH; Chou YH; Rubesin SE; Wu HP; Jeng WC; Hsu CC; Tiu CM; Chang T 《Radiology》1994,193(2):539
9.
Human anticentriole autoantibody in patients with scleroderma and Raynaud's phenomenon 总被引:5,自引:0,他引:5
Y Moroi I Murata A Takeuchi N Kamatani K Tanimoto R Yokohari 《Clinical immunology and immunopathology》1983,29(3):381-390
Unique autoantibody was found in sera from two different patients that reacted with centrioles of both cultured mammalian cells and human peripheral leukocytes as detected by the indirect immunofluorescent method. Sera from the same individuals, one with scleroderma and the other suffering from Raynaud's phenomenon, also stained the basal bodies of rat tracheal ciliated cells by the identical technique. Data from subsequent investigations have suggested that the antigen(s) involved in the reaction are water-insoluble protein(s) or polypeptide(s) associated with centrioles and are distinct from microtubular proteins or purine nucleoside phosphorylase. 相似文献
10.
The effects of antioxidant supplementation during Percoll preparation on human sperm DNA integrity 总被引:20,自引:6,他引:20
Hughes CM; Lewis SE; McKelvey-Martin VJ; Thompson W 《Human reproduction (Oxford, England)》1998,13(5):1240-1247
The integrity of sperm DNA is crucial for the maintenance of genetic
health. A major source of damage is reactive oxygen species (ROS)
generation; therefore, antioxidants may afford protection to sperm DNA. The
objectives of the study were, first, to measure the effects of antioxidant
supplementation in vitro on endogenous DNA damage in spermatozoa using the
single cell gel electrophoresis (comet) assay and, second, to assess the
effect of antioxidant supplementation given prior to X-ray irradiation on
induced DNA damage. Spermatozoa from 150 patients were prepared by Percoll
centrifugation in the presence of ascorbic acid (300, 600 microM), alpha
tocopherol (30, 60 microM), urate (200, 400 microM), or acetyl cysteine (5,
10 microM). DNA damage was induced by 30 Gy X-irradiation. DNA strand
breakage was measured using the comet assay. Sperm DNA was protected from
DNA damage by ascorbic acid (600 microM), alpha tocopherol (30 and 60
microM) and urate (400 microM). These antioxidants provided protection from
subsequent DNA damage by X-ray irradiation. In contrast, acetyl cysteine or
ascorbate and alpha tocopherol together induced further DNA damage.
Supplementation in vitro with the antioxidants ascorbate, urate and alpha
tocopherol separately has beneficial effects for sperm DNA integrity.
相似文献