全文获取类型
收费全文 | 255篇 |
免费 | 19篇 |
专业分类
儿科学 | 8篇 |
妇产科学 | 4篇 |
基础医学 | 51篇 |
口腔科学 | 5篇 |
临床医学 | 16篇 |
内科学 | 38篇 |
皮肤病学 | 10篇 |
神经病学 | 34篇 |
特种医学 | 2篇 |
外科学 | 54篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 2篇 |
眼科学 | 30篇 |
药学 | 11篇 |
中国医学 | 1篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 7篇 |
2022年 | 1篇 |
2021年 | 16篇 |
2020年 | 7篇 |
2019年 | 11篇 |
2018年 | 10篇 |
2017年 | 13篇 |
2016年 | 10篇 |
2015年 | 4篇 |
2014年 | 21篇 |
2013年 | 14篇 |
2012年 | 38篇 |
2011年 | 24篇 |
2010年 | 14篇 |
2009年 | 4篇 |
2008年 | 11篇 |
2007年 | 14篇 |
2006年 | 10篇 |
2005年 | 14篇 |
2004年 | 9篇 |
2003年 | 11篇 |
2002年 | 6篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1990年 | 1篇 |
1983年 | 1篇 |
排序方式: 共有274条查询结果,搜索用时 0 毫秒
1.
2.
The number of computer game users is increasing as computers and various IT devices in connection with the Internet are commonplace in all ages. In this research, in order to find the relevance of behavioral activity and its associated biosignal, biosignal changes before and after as well as during computer games were measured and analyzed for 31 subjects. For this purpose, a device to measure electrocardiogram, photoplethysmogram and skin temperature was developed such that the effect of motion artifacts could be minimized. The device was made wearable for convenient measurement. The game selected for the experiments was League of Legends?. Analysis on the pulse transit time, heart rate variability and skin temperature showed increased sympathetic nerve activities during computer game, while the parasympathetic nerves became less active. Interestingly, the sympathetic predominance group showed less change in the heart rate variability as compared to the normal group. The results can be valuable for studying internet gaming disorder. 相似文献
3.
S. Ravikumar M. Gnanadesigan A. Saravanan N. Monisha V. Brindha S. Muthumari 《Asian Pacific journal of tropical medicine》2012,5(11):887-890
ObjectiveTo identify the antibacterial potential of seagrass (Syringodium isoetifolium) associate microbes against bacterial pathogens.MethodsEumeration of microbial associates were analyzed with leaf and root samples of Syringodium isoetifolium. MIC and MBC were calculated for bacterial pathogens with microbial associates. Phylogenetic and GC-MS analysis were calculated for Actinomycetes sp. (Act01) which was the most potent.ResultsOf the isolated microbial associates phosphatase producing bacterial isolates were identified as maximum [(261.78±35.09) CFU×104/g] counts in root sample. Of the selected microbial isolates Actinomycete sp (Act01) showed broad spectrum of antibacterial activity against antibiotic resistant and fish bacterial pathogens. Phylogenetic analysis of Act01 showed maximum identities (99%) with the Streptomyces sp. (GU5500072). The 16s rDNA secondary structure of Act01 showed the free energy values as ?366.3 kkal/mol. The GC-MS analysis Act01 showed maximum retention value with 23.742 RT and the corresponding chemical class was identified as 1, 4-dihydroxy-2-(3-hydroxybutyl)-9, 10-anthraquinone 9, 10-anthrac.ConclusionsIn conclusion, Streptomyces sp. (GU045544.1) from Syringodium isoetifolium could be used as potential antibacterial agent. 相似文献
4.
5.
6.
Diabetes mellitus is a combined metabolic disorder which includes hyperglycemia,dyslipidemia,stroke and several other complications.Various groups all over the world are relentlessly working out the possible role of a vast number of genes associated with type 2 diabetes(T2DM).Inflammation is an important outcome of any kind of imbalance in the body and is therefore an indicator of several diseases,including T2DM.Various ethnic populations around the world show different levels of variations in single nucleotide polymorphisms(SNPs).The present review was undertaken to explore the association of cytokine gene polymorphisms with T2DM in populations of different ethnicities.This will lead to the understanding of the role of cytokine genes in T2DM risk and development.Association studies of genotypes of SNPs present in cytokine genes will help to identify risk haplotype(s)for disease susceptibility by developing prognostic markers and alter treatment strategies for T2DM and related complications.This will enable individuals at risk to take prior precautionary measures and avoid or delay the onset of the disease.Future challenges will be to understand the genotypic interactions between SNPs in one cytokine gene or several genes at different loci and study their association with T2DM. 相似文献
7.
Charan Jeet Arora Muhammad Rafiq Stephen Shumack Monisha Gupta 《The Australasian journal of dermatology》2020,61(1):e1-e9
There is currently no definitive treatment for vitiligo; various modalities include immune modulators phototherapy and skin camouflage. We investigated the efficacy and safety of topical tacrolimus either as monotherapy or combined therapy in the treatment of vitiligo. Electronic systematic search of the literature was carried out using four major databases. Randomised clinical trials (RCTs) that reported the use of topical tacrolimus in the treatment of human vitiligo have been included in a systematic review and meta-analysis. Meta-analysis was conducted via RevMan, and risk of bias was assessed through the Cochrane quality assessment tool. The protocol was published through PROSPERO (CRD42018112430). A total of 19 studies including 814 patients were included in our systematic review. The random-effects-model meta-analysis of two studies revealed that the tacrolimus and narrowband ultraviolet B (NB-UVB) combination therapy rates is better than NB-UVB alone in inducing >75% repigmentation [RR 1.34 (95% CI: 01.05–1.71), P = 0.02]. Tacrolimus and steroids had similar potency in acheiving >75% repigmentation [RR 1.02 (95% CI: 0.19–5.51), P = 0.98]. Meta-analysis of two studies revealed that the fractional laser and tacrolimus combination therapy is no better than tacrolimus alone in causing >75% repigmentation [RR 2.11 (95% CI: 0.87–5.09), P = 0.10]. Further investigating tacrolimus as mono- or adjuvant therapy for vitiligo is highly recommended. Combining tacrolimus to other treatment options such as steroids, phototherapy and laser may be superior to using tacrolimus alone. 相似文献
8.
The Australasian Psoriasis Collaboration view on methotrexate for psoriasis in the Australasian setting
下载免费PDF全文
![点击此处可从《The Australasian journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Marius Rademaker Monisha Gupta Megan Andrews Katherine Armour Chris Baker Peter Foley Kurt Gebauer Jacob George Diana Rubel John Sullivan 《The Australasian journal of dermatology》2017,58(3):166-170
The Australasian Psoriasis Collaboration reviewed methotrexate (MTX) in the management of psoriasis in the Australian and New Zealand setting. The following comments are based on expert opinion and a literature review. Low‐dose MTX (< 0.4 mg/kg per week) has a slow onset of action and has moderate to good efficacy, together with an acceptable safety profile. The mechanism of action is anti‐inflammatory, rather than immunosuppressive. For pretreatment, consider testing full blood count (FBC), liver and renal function, non‐fasting lipids, hepatitis serology, HbA1c and glucose. Body mass index and abdominal circumference should also be measured. Optional investigations in at‐risk groups include an HIV test, a QuantiFERON‐TB Gold test and a chest X‐ray. In patients without complications, repeat the FBC at 2–4 weeks, then every 3–6 months and the liver/renal function test at 3 months and then every 6 months. There is little evidence that a MTX test dose is of value. Low‐dose MTX rarely causes clinically significant hepatotoxicity in psoriasis. Most treatment‐emergent liver toxicity is related to underlying metabolic syndrome and non‐alcoholic fatty liver disease or non‐alcoholic steatohepatitis. Alcohol itself is not contraindicated, but should be limited to < 20 gm/day. [Correction added on 6 January 2017, after first online publication: ‘20 mg/day’ has been corrected to ‘20 gm/day’.] Although MTX is a potential teratogen post‐conception, there is little evidence for this pre‐conception. MTX does not affect the quality of sperm. There is no evidence that MTX reduces healing, so there is no specific need to stop MTX peri‐surgery. MTX may be used in combination with cyclosporine, acitretin, prednisone and anti‐tumour necrosis factor biologics. 相似文献
9.
Lawrence Lee MD MSc Monisha Sudarshan MD MPH Chao Li MD MSc Eric Latimer PhD Gerald M. Fried MD David S. Mulder MD Liane S. Feldman MD Lorenzo E. Ferri MD PhD 《Annals of surgical oncology》2013,20(12):3732-3739
Background
A recent randomized trial comparing minimally invasive (MIE) and open esophagectomy for esophageal cancer reported improved short-term outcomes. However, MIE has increased operative costs, and it is unclear whether the short-term benefits of MIE outweigh the increased operative costs. Therefore, the objective of this study was to determine the cost-effectiveness of MIE compared to open esophagectomy for esophageal cancer.Methods
A decision-analysis model was developed to estimate the expected costs and outcomes after MIE and open esophagectomy from a health care system perspective with a time horizon of 1 year. Costs were represented in 2012 Canadian dollars, and effectiveness was measured in quality-adjusted life-years (QALYs). Probabilistic sensitivity analysis assessed parameter uncertainty.Results
MIE was estimated to cost $1641 (95 % confidence interval 1565, 1718) less than open esophagectomy, with an incremental gain of 0.022 QALYs (95 % confidence interval 0.021, 0.023). MIE was therefore dominant over open esophagectomy. On deterministic sensitivity analyses, the results were most sensitive to variations in length of stay. Probabilistic sensitivity analysis demonstrated the robustness of the base case result, with 66, 77, and 82 % probabilities of cost-effectiveness at willingness-to-pay thresholds of $0/QALY, $50,000/QALY, and $100,000/QALY, respectively.Conclusions
MIE is cost-effective compared to open esophagectomy in patients with resectable esophageal cancer. 相似文献10.
Identification of novel non‐invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network
下载免费PDF全文
![点击此处可从《BJU international》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Adelle Dagher Adam Curatolo Monisha Sachdev Alisa J. Stephens Chris Mullins J. Richard Landis Adrie van Bokhoven Andrew El‐Hayek John W. Froehlich Andrew C. Briscoe Roopali Roy Jiang Yang Michel A. Pontari David Zurakowski Richard S. Lee Marsha A. Moses the MAPP Research Network 《BJU international》2017,120(1):130-142