全文获取类型
收费全文 | 3119篇 |
免费 | 185篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 77篇 |
妇产科学 | 60篇 |
基础医学 | 502篇 |
口腔科学 | 107篇 |
临床医学 | 258篇 |
内科学 | 745篇 |
皮肤病学 | 33篇 |
神经病学 | 375篇 |
特种医学 | 123篇 |
外科学 | 227篇 |
综合类 | 20篇 |
预防医学 | 258篇 |
眼科学 | 30篇 |
药学 | 222篇 |
中国医学 | 22篇 |
肿瘤学 | 263篇 |
出版年
2023年 | 34篇 |
2022年 | 80篇 |
2021年 | 142篇 |
2020年 | 93篇 |
2019年 | 92篇 |
2018年 | 101篇 |
2017年 | 89篇 |
2016年 | 99篇 |
2015年 | 81篇 |
2014年 | 139篇 |
2013年 | 168篇 |
2012年 | 273篇 |
2011年 | 252篇 |
2010年 | 140篇 |
2009年 | 139篇 |
2008年 | 196篇 |
2007年 | 202篇 |
2006年 | 172篇 |
2005年 | 147篇 |
2004年 | 90篇 |
2003年 | 124篇 |
2002年 | 107篇 |
2001年 | 23篇 |
2000年 | 23篇 |
1999年 | 24篇 |
1998年 | 12篇 |
1997年 | 16篇 |
1996年 | 12篇 |
1995年 | 20篇 |
1994年 | 14篇 |
1993年 | 14篇 |
1992年 | 8篇 |
1991年 | 11篇 |
1990年 | 13篇 |
1989年 | 17篇 |
1988年 | 17篇 |
1987年 | 8篇 |
1986年 | 10篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1979年 | 7篇 |
1975年 | 7篇 |
1974年 | 7篇 |
1973年 | 10篇 |
1972年 | 6篇 |
1971年 | 10篇 |
1970年 | 6篇 |
1969年 | 6篇 |
1968年 | 9篇 |
1967年 | 6篇 |
排序方式: 共有3331条查询结果,搜索用时 15 毫秒
1.
Ewelina Kazimierczyk Andrzej Eljaszewicz Paula Zembko Ewa Tarasiuk Malgorzata Rusak Agnieszka Kulczynska-Przybik Marta Lukaszewicz-Zajac Karol Kaminski Barbara Mroczko Maciej Szmitkowski Milena Dabrowska Bozena Sobkowicz Marcin Moniuszko Agnieszka Tycinska 《Pharmacological reports : PR》2019,71(1):73-81
Background
Acute myocardial infarction (AMI) causes irreversible myocardial damage and release of inflammatory mediators, including cytokines, chemokines and miRNAs. We aimed to investigate changes in the levels of cytokines (IL-6, TNF-α and IL-10), miRNAs profiles (miR-146 and miR-155) and distribution of different monocyte subsets (CD14++CD16-, CD14++CD16+, CD14+CD16++) in the acute and post-healing phases of AMI.Methods
In eighteen consecutive AMI patients (mean age 56.78?±?12.4 years, mean left ventricle ejection fraction – LVEF: 41.9?±?9.8%), treated invasively, monocyte subsets frequencies were evaluated (flow cytometry), cytokine concentrations were analyzed (ELISA) as well as plasma miRNAs were isolated twice – on admission and after 19.2?±?5.9 weeks of follow-up. Measurements were also performed among healthy volunteers.Results
AMI patients presented significantly decreased frequencies of classical cells in comparison to healthy controls (median 71.22% [IQR: 64.4–79.04] vs. 84.35% [IQR: 81.2–86.7], p?=?0.001) and higher percent of both intermediate and non-classical cells, yet without statistical significance (median 6.54% [IQR: 5.14–16.64] vs. 5.87% [IQR: 4.48–8.6], p?=?0.37 and median 5.99% [IQR: 3.39–11.5] vs. 5.26% [IQR: 3.62–6.2], p?=?0.42, respectively). In AMI patients both, analyzed plasma miRNA concentrations were higher than in healthy subjects (miR-146: median 5.48 [IQR: 2.4–11.27] vs. 1.84 [IQR: 0.87–2.53], p?=?0.003; miR-155: median 25.35 [IQR: 8.17–43.15] vs. 8.4 [IQR: 0.08–16.9], p?=?0.027, respectively), and returned back to the values found in the control group in follow-up. miR-155/miR-146 ratio correlated with the frequencies of classical monocytes (r=0.6, p?=?0.01) and miR-155 correlated positively with the concentration of inflammatory cytokines ? IL-6 and TNF-α.Conclusions
These results may suggest cooperation of both pro-inflammatory and anti-inflammatory signals in AMI in order to promote appropriate healing of the infarcted myocardium. 相似文献2.
Estrogenic microenvironment generated by organochlorine residues in adipose mammary tissue modulates biomarker expression in ERα-positive breast carcinomas
下载免费PDF全文
![点击此处可从《Breast cancer research : BCR》网站下载免费的PDF全文](/ch/ext_images/free.gif)
3.
4.
Solyakov Lev Dobrota Dušan Drany Oleg Vachova Milena Machač Stanislav Mezešova Viera Bachurin Sergey Lombardi Vincenzo 《Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid》1995,25(2-3):123-134
Molecular and chemical neuropathology - Changes in the functioning of the glutamatergic system in rabbit brain were studied after partial brain ischemia and reperfusion. In vitro studies were... 相似文献
5.
Milena Soares Santos Guilherme de Sousa Ribeiro Tainara Queiroz Oliveira Renan Cardoso Nery Santos Edilane Gouveia Kátia Salgado Daniele Takahashi Cleuber Fontes Leila Carvalho Campos Mitermayer Galvão Reis Albert Icksang Ko Joice Neves Reis 《International journal of infectious diseases》2009,13(4):456-461
6.
7.
Milena G. J. Jahoda Helen Brandenburg Titia Cohen-Overbeek Frans J. Los Eva S. Sachs Juriy W. Wladimiroff 《American journal of medical genetics. Part A》1993,46(5):483-485
Data from 4,300 consecutive cases following prenatal diagnosis by transcervical (TC) CVS (n = (1,570) and transabdominal (TA) CVS (n = 2,370) were evaluated. In the follow-up study only infants examined by a physician were included. Gestational age varied between 8.5 and 11.6 weeks (mean 10.3 weeks) for TC-CVS and between 9.3 and 20 weeks (mean 12.3 weeks) for TA-CVS 98% of TC-CVS was performed at 9–10 weeks, 80.7% of TA-CVS procedures were carried out at 12–15 weeks. Selective termination took place in 97 cases of TC-CVS (6.1%) and in 72 cases of TA-CVS (2.6%). Another 8 Women had a termination for psychosocial reasons, resulting in 4,123 (1,469 TC, 2,645 TA) continuing pregnancies. The overall fetal loss rare <28 weeks was 5.4% (n = 80) for TC-CVS and 2.6% (n = 70) for TA-CVS. The overall incidence of congenital abnormalities after birth was 0.9%. Two terminal transversal limb defects were detected in the TC-CVS group (0.14%) against one (0.04%) in the TA-CVS group. © 1993 Wiley-Liss, Inc. 相似文献
8.
D. Maimone P. Annunziata C. Cioni A. Leonardi G. C. Guazzi 《Acta neurologica Scandinavica》1994,90(4):285-292
Human immunodeficiency virus type 1 (HIV-1)-infected individuals frequently develop a broad spectrum of neurological syndromes, classified as HIV-1-associated cognitive/motor complex. Diffuse demyelination of hemispheric white matter is a commonly observed in HIV-1 infected brain, but the events leading to myelin destruction are still obscure. Since oligodendrocyte infection by HIV-1 is not proven as yet, myelin damage in HIV-1 infection may result from indirect mechanisms such as the excessive release of myelinotoxic substances or the triggering of autoimmune responses directed to myelin constituents. To verify the latter hypothesis, we searched for elevated anti-myelin basic protein (MBP) IgG levels in the cerebrospinal fluid (CSF) and serum of 25 patients with HIV-1 infection, 12 with multiple sclerosis (MS), and 9 with non-inflammatory neurological diseases (NIND). CSF, but not serum, anti-MBP IgG levels were more frequently elevated in HIV-1+ (16/25, 64%) than in MS (3/12, 25%) or NIND (0/9) patients. By using the anti-MBP IgG index, the anti-MBP IgG antibody specificity index (ASI), and the search for anti-MBP oligoclonal IgG, we ascertained that anti-MBP IgG were produced within the CNS in 13 of 25 (52%) HIV-1+ , in 6 of 12 (50%) MS, and in none of NIND patients. The incidence of increased CSF anti-MBP IgG levels was higher among HIV-1+ patients at stage II–III (4/4, 100%) or at stage IV B (7/9, 78%) than among those at stage IV C–IV D (5/12, 42%). Although our data indicate that intrathecal anti-MBP IgG may occur early during HIV-1 infection and that they are more common in patients with HIV-1-associated cognitive/motor complex, the possible demyelinating role of these antibodies remains to be demonstrated. 相似文献
9.
Christopher L. Hansen Richard A. Goldstein Olakunle O. Akinboboye Daniel S. Berman Elias H. Botvinick Keith B. Churchwell C. David Cooke James R. Corbett S. James Cullom Seth T. Dahlberg Regina S. Druz Edward P. Ficaro James R. Galt Ravi K. Garg Guido Germano Gary V. Heller Milena J. Henzlova Mark C. Hyun Lynne L. Johnson April Mann Benjamin D. McCallister Robert A. Quaife Terrence D. Ruddy Senthil N. Sundaram Raymond Taillefer R. Parker Ward John J. Mahmarian 《Journal of nuclear cardiology》2007,14(6):e39-e60
10.
The thiosulfate:cyanide sulfurtransferase (rhodanese) enzyme (EC 2.8.1.1.) was studied in human leukocytes from control subjects and from nine patients with Leber's hereditary optic atrophy. Enzyme activity was proportional to protein concentration in the tested range (0.09 to 0.39 mg) as well as to incubation time. The optimal pH for reaction was 8.7 and the apparent Km for thiosulfate was 7 X 10(-3) M. No significant difference of enzyme activity was present in Leber's disease. 相似文献