全文获取类型
收费全文 | 5204篇 |
免费 | 244篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 95篇 |
妇产科学 | 54篇 |
基础医学 | 697篇 |
口腔科学 | 95篇 |
临床医学 | 358篇 |
内科学 | 1546篇 |
皮肤病学 | 120篇 |
神经病学 | 503篇 |
特种医学 | 141篇 |
外科学 | 717篇 |
综合类 | 22篇 |
一般理论 | 1篇 |
预防医学 | 219篇 |
眼科学 | 76篇 |
药学 | 354篇 |
中国医学 | 18篇 |
肿瘤学 | 413篇 |
出版年
2023年 | 33篇 |
2022年 | 70篇 |
2021年 | 129篇 |
2020年 | 86篇 |
2019年 | 89篇 |
2018年 | 101篇 |
2017年 | 66篇 |
2016年 | 105篇 |
2015年 | 103篇 |
2014年 | 173篇 |
2013年 | 214篇 |
2012年 | 292篇 |
2011年 | 320篇 |
2010年 | 152篇 |
2009年 | 129篇 |
2008年 | 241篇 |
2007年 | 248篇 |
2006年 | 238篇 |
2005年 | 247篇 |
2004年 | 252篇 |
2003年 | 248篇 |
2002年 | 249篇 |
2001年 | 187篇 |
2000年 | 172篇 |
1999年 | 158篇 |
1998年 | 77篇 |
1997年 | 52篇 |
1996年 | 61篇 |
1995年 | 36篇 |
1994年 | 34篇 |
1993年 | 37篇 |
1992年 | 100篇 |
1991年 | 62篇 |
1990年 | 60篇 |
1989年 | 68篇 |
1988年 | 61篇 |
1987年 | 67篇 |
1986年 | 46篇 |
1985年 | 52篇 |
1984年 | 42篇 |
1983年 | 40篇 |
1982年 | 18篇 |
1979年 | 27篇 |
1977年 | 28篇 |
1976年 | 14篇 |
1974年 | 13篇 |
1969年 | 13篇 |
1968年 | 18篇 |
1967年 | 15篇 |
1966年 | 13篇 |
排序方式: 共有5457条查询结果,搜索用时 15 毫秒
1.
2.
The role of hypertension and antihypertensive drugs in cardiovascular complications was evaluated in 380 elderly people living in the Tokyo Metropolitan Gerontology Center. The subjects were classified into four groups according to the presence or absence of hypertension and their antihypertensive treatment, and followed up prospectively for 5 years from 1979 to 1984. The average age of each group was 74 to 76 years. Cerebrovascular disease was observed in 19.3% of male hypertensives and 10.1% of male normotensives (p = 0.078). The drug treated group revealed no cerebral hemorrhage and less cerebral infarction. This tendency was not observed in females. Ischemic heart disease was prevalent in the drug treated group (10.9% vs 4.5%, p = 0.023) irrespective of blood pressure level. Risk factors such as body mass index, skinfold thickness, serum cholesterol, albumin, creatinine, blood urea nitrogen and uric acid at entry were elevated in the drug treated group. Diuretics were used in 92% of the drug treated group; in 53% as monotherapy and in 39% as combination therapy with other antihypertensive agents. The metabolic effect of diuretics may increase the incidence of ischemic heart disease in the elderly. We might conclude that hypertension in the aged accelerates cerebrovascular complications, and that antihypertensive treatment is effective even in this group. However, the wide use of diuretics could increase the incidence of ischemic heart disease. Careful selection of antihypertensive drugs as well as dose adjustment are needed in the treatment of elderly hypertensives. 相似文献
3.
4.
K. Arima Minako Nakamura Nobuhiko Sunohara Masafumi Ogawa Midori Anno Yoko Izumiyama Shigeo Hirai Kazuhiko Ikeda 《Acta neuropathologica》1997,93(6):558-566
Coiled bodies and interfascicular threads are conspicuous white matter abnormalities of brains of patients with progressive
supranuclear palsy (PSP). Both structures are argyrophilic and immunoreactive for the microtubule-binding protein tau. This
report concerns the ultrastructural localization of interfascicular threads and their relationship to coiled bodies in five
PSP patients. We showed for the first time that abnormal tubules with a 13- to 15-nm diameter and fuzzy outer contours were
the common structures of coiled bodies in the oligodendroglial perikarya and of interfascicular threads. Moreover, the tubules
were immunolabeled by anti-tau antibodies. The abnormal tau-positive tubules of interfascicular threads were located in the
inner loop of the myelin sheath. Our study further indicated that the thread-like structures in the white matter comprised,
at least in part, oligodendroglial processes, and that they were also present in gray matter. We consider that the formation
of coiled bodies in the perikarya and of interfascicular threads represents a common cytoskeletal abnormality of the oligodendroglia
of PSP patients. Moreover, even though the white matter alterations of PSP resemble those of corticobasal degeneration, there
are certain ultrastructural differences in the abnormal oligodendroglial tubules of the two diseases.
Received: 4 October 1996 / Accepted: 6 December 1996 相似文献
5.
N. Inotsume M. Nishimura M. Nakano S. Fujiyama K. Sagara T. Sato K. Matsushita Y. Imai H. Matsui 《European journal of clinical pharmacology》1990,38(3):313-314
Summary The effect of haemodialysis on the pharmacokinetics of oral famotidine has been studied in five elderly anuric patients. Famotidine 20 mg was administered in a cross-over design to patients on and not on haemodialysis.The elimination rate constant of haemodialysis (k) was 4.6-fold larger than the systemic elimination rate constant (ke). Although the mean maximum serum concentration of famotidine during haemodialysis (141.5 ng·ml–1) was not significantly lower than that without haemodialysis (195.6 ng·ml–1), the AUC up to 5 h during haemodialysis was significantly decreased to 58.1% of the value without it.The data suggest that famotidine is dialysable by haemodialysis. 相似文献
6.
7.
Elderly onset rheumatoid arthritis (RA) is difficult to diagnose definitively when the patients note their first symptoms of arthritis above the age of 75 years old. In this report, we reviewed the clinical features of elderly onset RA and its diagnosis. The subjects included 4 females, aged 78, 83, 84 and 93 years, respectively. The onsets were abrupt in 2 cases and more slowly arriving in the other 2. Shoulder joints and wrist joints were involved in all cases. Knee joints, finger joints and foot joints were involved in 3 cases and the elbow was involved in one case. Anti-RA treatment quickly attenuated the acute and severe arthritis and brought down the high CRP level associated with vivid inflammatory activity of RA. The RAPA value was very high in all but one of the cases. Severe destructive findings in radiography was undetectable in the major joints (e.g. shoulder, hip and knee joints). Radiographic findings in wrist and finger joints were also very difficult to differentiate from arthrosis and osteoporosis. On the other hand, RA involvement in the cervical spine was certain in the radiographs; 1 case had anterior atlantoaxial subluxation and 2 cases had subaxial intervertebral erosion. Pathological radiographic findings in the cervical spine are useful for the diagnosis of elderly onset RA. 相似文献
8.
We report a case diagnosed as bilateral ureteritis cystica by ureteroscopic examination. A 51-year-old female was admitted with pyuria and proteinuria. Retrograde pyelography revealed multiple, small, smooth and round punched-out defects in the bilateral lower ureters. Ureteroscopic examination and punch biopsy were performed with a suspected diagnosis of ureteritis cystica. The histological examination revealed chronic ureteritis. This patient was given conservative treatment (chemotherapy) and careful follow-up. 相似文献
9.
The effect of inclination of the distal radius to subsequent lunate collapse is controversial. Therefore we evaluated the postoperative x-ray course of 10 patients with stage II, III, or IV Kienb?ck's disease who were treated only with radial shortening and followed up for an average of 25 months. The three patients who became worse as determined by x-ray evaluation had lunate fossa inclinations of less than 12 degrees after surgery. The four patients who improved had lunate fossa inclinations greater than 12 degrees. Appropriate radial shortening with adjunct wedge osteotomy to increase lunate fossa inclination may prevent further lunate collapse. 相似文献
10.
Newborn infant with maternal anti-SSA antibody-induced complete heart block accompanying cardiomyopathy. 总被引:2,自引:0,他引:2
Newborn case of maternal anti-SSA antibody-induced congenital complete heart block (CCHB) accompanying cardiomyopathy is presented. Unexpectedly, she died of ventricular tachycardia, not bradycardia, 6 days after birth. Autopsy revealed left ventricular cardiomyopathy with endocardial fibroelastosis. Thus, when evaluating fetal cardiac performance in cases of maternal anti-SSA antibody-induced CCHB, it is necessary to pay attention to myocardial attributes such as endocardial hyperplasia. 相似文献