全文获取类型
收费全文 | 861篇 |
免费 | 50篇 |
专业分类
耳鼻咽喉 | 80篇 |
儿科学 | 14篇 |
妇产科学 | 20篇 |
基础医学 | 27篇 |
口腔科学 | 12篇 |
临床医学 | 95篇 |
内科学 | 104篇 |
神经病学 | 21篇 |
特种医学 | 39篇 |
外科学 | 164篇 |
综合类 | 5篇 |
预防医学 | 45篇 |
药学 | 14篇 |
中国医学 | 2篇 |
肿瘤学 | 269篇 |
出版年
2021年 | 14篇 |
2020年 | 8篇 |
2019年 | 18篇 |
2018年 | 14篇 |
2017年 | 10篇 |
2016年 | 19篇 |
2015年 | 21篇 |
2014年 | 28篇 |
2013年 | 27篇 |
2012年 | 49篇 |
2011年 | 27篇 |
2010年 | 18篇 |
2009年 | 22篇 |
2008年 | 37篇 |
2007年 | 25篇 |
2006年 | 31篇 |
2005年 | 43篇 |
2004年 | 22篇 |
2003年 | 29篇 |
2002年 | 30篇 |
2001年 | 30篇 |
2000年 | 10篇 |
1999年 | 28篇 |
1998年 | 17篇 |
1997年 | 15篇 |
1996年 | 21篇 |
1995年 | 20篇 |
1994年 | 13篇 |
1993年 | 11篇 |
1992年 | 19篇 |
1991年 | 20篇 |
1990年 | 21篇 |
1989年 | 22篇 |
1988年 | 37篇 |
1987年 | 19篇 |
1986年 | 17篇 |
1985年 | 11篇 |
1984年 | 11篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 13篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1974年 | 6篇 |
1970年 | 6篇 |
1968年 | 3篇 |
1966年 | 2篇 |
1923年 | 2篇 |
排序方式: 共有911条查询结果,搜索用时 31 毫秒
1.
This is an analysis of 37 previously untreated patients with squamous cell carcinoma of the maxillary sinus treated with curative intent at the University of Florida from January 1966 through January 1984. All patients were followed for at least two years and 86 per cent (32/27) were followed for a minimum of five years. Patients were treated for cure with radiation therapy alone (25), surgery alone (1), or surgery and preoperative (6) or postoperative (5) radiation therapy. This study presents the results of treatment and the incidence of treatment-related complications in this group of patients. 相似文献
2.
3.
The effect of immobilization on goat knees following reconstruction of the anterior cruciate ligament 总被引:2,自引:0,他引:2
J H Roth H V Mendenhall G K McPherson 《Clinical orthopaedics and related research》1988,(229):278-282
Significant patellofemoral chondromalacia was observed three months after operations on goat knees that had an excised anterior cruciate ligament (ACL) replaced and then were immobilized for six weeks with a rigid external pin and frame fixator. To determine if the patellofemoral morbidity rate could be reduced, another group of goats was treated with the same operation but without immobilization. The legs of the animals in the immobilized group had muscle weakness and the animals only occasionally used their legs for the next three to four weeks. The animals in the mobilized group protected the leg for only one to two days after surgery, and by ten to 12 days were actively moving the knee. Severe patellofemoral articular cartilage erosions occurred in the immobilized goats but not in the mobilized group. Postoperative immobilization was detrimental to the joint function and to a successful ACL reconstruction. 相似文献
4.
S P Stringer J R Jordan W M Mendenhall J T Parsons N J Cassisi R R Million 《Otolaryngology--head and neck surgery》1992,107(3):395-398
The mandibular lingual releasing approach to oral cavity and oropharyngeal tumors provides excellent visualization for resection while integrity of the mandibular arch is preserved. A lingual floor-of-mouth flap is created, which allows delivery of these structures directly into the neck without lip splitting, mandibulotomy, or mandibulectomy. The procedure was carried out on 15 patients between 1987 and 1991, with followup ranging from 2 to 50 months. Nine patients had received previous radiation, whereas planned postoperative radiation was administered to five patients. The visualization afforded by this technique was very good, in that 12 patients had clear margins of resection. Three patients had close margins; recurrent disease developed in one of these patients 18 months later. Twelve of the patients were able to maintain their weight with an oral diet alone. Four postoperative fistulae occurred, three of these were in patients who had not been previously irradiated. The single fistula that did not spontaneously heal occurred in a patient who had received previous radiation and was also on long-term corticosteroids. Mandibular osteoradionecrosis developed in two patients who received postoperative radiation. The complication rate after previous radiation is acceptable; however, there is risk of mandibular osteoradionecrosis after high-dose postoperative radiation. 相似文献
5.
In a prospective, randomized study of insemination with donor semen,
intracervical insemination by straw was compared with insemination using a
cervical cap with an intracervical reservoir. A total of 91 patients
completed 486 treatment cycles. There were no significant differences in
age, parity, indication for insemination by donor, or method of cycle
monitoring between women who became pregnant and those who did not conceive
with either insemination method. In 236 standard intracervical insemination
cycles, 14 patients became pregnant (5.9% per cycle), whereas 38 patients
conceived in 250 cervical cap cycles (15.2% per cycle). Both the crude
pregnancy rates and the cumulative pregnancy rates calculated by the
Kaplan-Meier life-table method were significantly different (chi(2)-test, P
< 0.001, and log-rank test, P < 0.005 respectively). Pregnancy rates
in artificial insemination with cryopreserved donor semen may be improved
by the use of a cervical cap when compared to cervical insemination by
straw. The use of the cervical cap may prolong the exposure of the
spermatozoa to the cervical mucus and prevent the backflow of semen into
the vagina.
相似文献
6.
Postoperative radiotherapy for locally advanced colon cancer 总被引:1,自引:0,他引:1
Dr. E. Henry Amos MD William M. Mendenhall MD Patricia J. McCarty BA John O. Gage MD J. Logan Emlet MD Gerald C. Lowrey MD Craig A. Peterson MD Warren R. Amos MD 《Annals of surgical oncology》1996,3(5):431-436
Background: The role of adjuvant postoperative radiotherapy for locally advanced colon cancer is not well documented.
Methods: Seventy-eight patients who underwent a complete resection of B2-C colon cancer received postoperative radiotherapy. Twenty-eight
patients received ⩽45 Gy; 50 patients received 50–55 Gy. Twenty-seven patients received adjuvant fluorouracil-based chemotherapy.
All patients were followed for a minimum of 3 years; no patients were lost to follow-up.
Results: The overall local control rate was 88%. The 5-year actuarial rate of local control was 96% after 50–55 Gy postoperative radiotherapy
compared with 76% after <50 Gy (p=0.0095). Multivariate analysis of local control showed that only radiotherapy dose significantly
influenced this end point. Cause-specific survival rates at 5 years were B2, 67%; B3, 90%; C1, 100%; C2, 61%; C3, 36%; and
overall, 63%. Multivariate analysis of cause-specific survival showed that only stage significantly influenced this end point.
Bowel obstruction caused by adhesions developed in three patients and required a laparotomy; radiation-induced sarcoma developed
in one additional patient.
Conclusions: Postoperative radiotherapy appears to reduce the risk of local recurrence in patients with locally advanced colon cancer.
The optimal dose is probably 50–55 Gy at 1.8 Gy per fraction. Postoperative radiotherapy may improve cause-specific survival
for patients with stages B3 and C2 cancers. 相似文献
7.
W. Robert Lee William M. Mendenhall James T. Parsons Rodney R. Million 《Head & neck》1993,15(4):320-324
Sixty-seven patients with 68 stage T4 carcinomas of the skin of the head and neck were treated with radical radiotherapy at the University of Florida between October 1964 and November 1989. Thirty-three lesions were previously untreated and 35 were recurrent. Twenty-nine lesions were squamous cell carcinomas, 37 were basal cell carcinomas, and 2 were basosquamous carcinomas. Minimum follow-up was 2 years. The 5-year local control, local control including surgical salvage, and cause-specific survival probabilities were 53%, 74%, and 75%, respectively. Local control rates with radiotherapy alone were poorer in patients with recurrent lesions (41% vs. 67%, p = .07) or bone involvement (40% vs. 62%, p = .08). Results were analyzed by multivariate methods using local control, local control with surgical salvage, and cause-specific survival as endpoints. The parameters analyzed were histology; size of primary lesion; previous treatment (previously untreated vs. recurrent); involvement of bone, nerve, or cartilage; and skeletal muscle invasion. Three important prognostic factors were identified, each predictive of poorer ultimate local control and cause-specific survival rates: (a) bone involvement (p < .01); (b) recurrent lesions (p < .01); and (c) nerve involvement (p < .02). Radiotherapy alone can control advanced carcinomas of the skin of the head and neck, although lesions that have recurred after prior treatment and those with involvement of bone or nerve are associated with a lower likelihood of cure. 相似文献
8.
Low-artifact intravascular devices: MR imaging evaluation 总被引:2,自引:0,他引:2
Teitelbaum GP; Ortega HV; Vinitski S; Stern H; Tsuruda JS; Mitchell DG; Rifkin MD; Bradley WG Jr 《Radiology》1988,168(3):713-719
Flow-phantom magnetic resonance (MR) imaging, with use of both spin-echo (SE) and gradient-echo (GRE) techniques at 1.5 T, was performed on the percutaneous Greenfield (beta-III titanium alloy [TMA wire]), Amplatz (MP32-N alloy), and Simon nitinol filters and TMA wire facsimiles of the bird's nest, Gunther, new retrievable, and Amplatz vena caval filters. SE imaging allowed detection of thrombi as small as 5 X 5 mm trapped within the percutaneous Greenfield, Simon nitinol, and TMA-wire facsimile filters; with the MP32-N Amplatz filter, a larger volume of thrombus (10 X 20-mm clots) was necessary for clot detection. GRE imaging allowed detection of intraluminal tilting of the percutaneous Greenfield and facsimile Amplatz (TMA-wire) filters. GRE imaging was useful for demonstrating postfilter turbulence due to clots, which was greatest for the Amplatz filter. Imaging of facsimile vascular devices made of tantalum or TMA wire did not cause the severe "black-hole" MR artifacts typical of the stainless-steel devices. SE and GRE imaging were very useful for determining caval patency in two patients with previously placed Mobin-Uddin filters. Noninvasive MR evaluation of blood vessels in the presence of a variety of low-artifact intravascular devices appears feasible. 相似文献
9.
10.
Experimental mechanical and histologic evaluation of the Kennedy ligament augmentation device 总被引:9,自引:0,他引:9
G K McPherson H V Mendenhall D F Gibbons H Plenk W Rottmann J B Sanford J C Kennedy J H Roth 《Clinical orthopaedics and related research》1985,(196):186-195
Reconstruction of the knee with a chronic injury to the anterior cruciate ligament is an unsolved problem. Biologic graft substitutes have failed to maintain knee stability in the longer postreconstruction intervals. In an attempt to overcome the limitations in graft performance, synthetic materials have been proposed to augment the biologic tissue. In this study, a 6-mm polypropylene braid Ligament Augmentation Device (LAD) possessing a tensile strength of 1500 N and excellent fatigue and creep properties was investigated as an adjunct to the MacIntosh/Marshall Over-the-Top repair. A two-year animal study of 54 adult goats was conducted in which experimental ACL defects were created and reconstructed with a transplant consisting of a portion of the rectus femoris tendon, prepatellar tissue, and the central one-third of the patellar tendon. The goats were equally divided between nonaugmented and LAD-augmented groups and sacrificed at three, six, 12, and 24 months after surgery. Mechanically, the augmented transplants were substantially stronger at the time of initial implantation (364N versus 26N) and again at two years (841N versus 528N). Intermediate times did not demonstrate a difference in strength. Histologically, the augmented transplants consisted of a loosely organized fibrous capsule surrounding the LAD. At 24 months, "insertion fibers" were noted to provide continuity between the fibrous tissue and bone on both the tibia and femur. 相似文献