全文获取类型
收费全文 | 2167篇 |
免费 | 117篇 |
国内免费 | 84篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 93篇 |
妇产科学 | 35篇 |
基础医学 | 262篇 |
口腔科学 | 47篇 |
临床医学 | 273篇 |
内科学 | 522篇 |
皮肤病学 | 55篇 |
神经病学 | 161篇 |
特种医学 | 378篇 |
外科学 | 138篇 |
综合类 | 29篇 |
预防医学 | 105篇 |
眼科学 | 10篇 |
药学 | 129篇 |
中国医学 | 3篇 |
肿瘤学 | 117篇 |
出版年
2022年 | 20篇 |
2021年 | 39篇 |
2020年 | 15篇 |
2019年 | 36篇 |
2018年 | 50篇 |
2017年 | 33篇 |
2016年 | 32篇 |
2015年 | 47篇 |
2014年 | 35篇 |
2013年 | 52篇 |
2012年 | 67篇 |
2011年 | 62篇 |
2010年 | 78篇 |
2009年 | 70篇 |
2008年 | 58篇 |
2007年 | 92篇 |
2006年 | 65篇 |
2005年 | 66篇 |
2004年 | 35篇 |
2003年 | 49篇 |
2002年 | 51篇 |
2001年 | 42篇 |
2000年 | 38篇 |
1999年 | 38篇 |
1998年 | 100篇 |
1997年 | 95篇 |
1996年 | 118篇 |
1995年 | 92篇 |
1994年 | 93篇 |
1993年 | 75篇 |
1992年 | 38篇 |
1991年 | 49篇 |
1990年 | 40篇 |
1989年 | 51篇 |
1988年 | 47篇 |
1987年 | 37篇 |
1986年 | 49篇 |
1985年 | 47篇 |
1984年 | 27篇 |
1983年 | 33篇 |
1982年 | 25篇 |
1981年 | 24篇 |
1980年 | 21篇 |
1979年 | 10篇 |
1978年 | 16篇 |
1977年 | 22篇 |
1976年 | 18篇 |
1975年 | 11篇 |
1974年 | 10篇 |
1970年 | 9篇 |
排序方式: 共有2368条查询结果,搜索用时 15 毫秒
1.
Krishna Pillai Javid Akhter Terence C. Chua Mena Shehata Nayef Alzahrani Issan Al-Alem David L. Morris 《Medicine》2015,94(9)
Thermal ablation of liver tumors near large blood vessels is affected by the cooling effect of blood flow, leading to incomplete ablation. Hence, we conducted a comparative investigation of heat sink effect in monopolar (MP) and bipolar (BP) radiofrequency ablation (RFA), and microwave (MW) ablation devices.With a perfused calf liver, the ablative performances (volume, mass, density, dimensions), with and without heat sink, were measured. Heat sink was present when the ablative tip of the probes were 8.0 mm close to a major hepatic vein and absent when >30 mm away. Temperatures (T1 and T2) on either side of the hepatic vein near the tip of the probes, heating probe temperature (T3), outlet perfusate temperature (T4), and ablation time were monitored.With or without heat sink, BP radiofrequency ablated a larger volume and mass, compared with MP RFA or MW ablation, with latter device producing the highest density of tissue ablated. MW ablation produced an ellipsoidal shape while radiofrequency devices produced spheres.Percentage heat sink effect in Bipolar radiofrequency : Mono-polar radiofrequency : Microwave was (Volume) 33:41:22; (mass) 23:56:34; (density) 9.0:26:18; and (relative elipscity) 5.8:12.9:1.3, indicating that BP and MW devices were less affected.Percentage heat sink effect on time (minutes) to reach maximum temperature (W) = 13.28:9.2:29.8; time at maximum temperature (X) is 87:66:16.66; temperature difference (Y) between the thermal probes (T3) and the temperature (T1 + T2)/2 on either side of the hepatic vessel was 100:87:20; and temperature difference between the (T1 + T2)/2 and temperature of outlet circulating solution (T4), Z was 20.33:30.23:37.5.MW and BP radiofrequencies were less affected by heat sink while MP RFA was the most affected. With a single ablation, BP radiofrequency ablated a larger volume and mass regardless of heat sink. 相似文献
2.
3.
4.
Regression of lymphomatous skin deposits in a chronic lymphocytic leukemia patient treated with the Toll-like receptor-7/8 agonist, imiquimod. 总被引:2,自引:0,他引:2
David E Spaner Richard L Miller Jenny Mena Larry Grossman Vicki Sorrenti Yonghong Shi 《Leukemia & lymphoma》2005,46(6):935-939
The identification of clinically relevant, active immunomodulatory agents is important for developing immunotherapeutic approaches to chronic lymphocytic leukemia (CLL) and other B-cell lymphomas that are not curable with conventional chemotherapy. In this investigation, the imidazoquinoline Toll-like receptor (TLR)-7/8 agonist, imiquimod, was found to mediate the clearance of a lymphomatous skin lesion in a CLL patient. Imidazoquinolines also activated TLR-7/8 signaling pathways, resulting in increased expression of costimulatory molecules on circulating tumor cells. These observations extend the therapeutic spectrum of imiquimod to cutaneous B-cell lymphomas and suggest the use of TLR-7/8 agonists in CLL immunotherapy. 相似文献
5.
6.
7.
8.
J. Randolph Swartz Ira M. Lesser Kyle B. Boone Bruce L. Miller Ismael Mena 《International journal of geriatric psychiatry》1995,10(6):437-446
Global and regional cerebral blood flow (CBF) were evaluated with single photon emission computerized tomography (SPECT) utilizing both 133Xenon (133Xe) (47 subjects, 47–82 years old) and 99Tc-hexamethylpropyleneamine oxime (99Tc-HMPAO) (27 subjects, 47–80 years old). The 133Xe results showed: among total subjects, no age-related decline in global CBF, but a significant regional decline in the occipital lobe (p < 0.05); among men, significant age-related declines in global, frontal, temporal, occipital and right hemisphere CBF (all p < 0.05); among women, no age-related decline in global or regional CBF. The 99Tc-HMPAO results showed no age-related decline in either global or regional perfusion among total subjects, men or women. These results suggest that age-related global and regional (including frontal lobe) CBF declines do not occur in healthy control subjects after the age of 45 years. However, gender differences in age-related CBF changes warrant further study. 相似文献
9.
Antinori Andrea Cingolani Antonella Lorenzini Patrizia Giancola Maria Letizia Uccella Ilaria Bossolasco Simona Grisetti Susanna Moretti Francesca Vigo Beniamino Bongiovanni Marco Del Grosso Bruno Arcidiacono Maria Irene Fibbia Giovanni Carlo Mena Maurizio Finazzi Maria Grazia Guaraldi Giovanni Ammassari Adriana Monforte Antonella dArminio Cinque Paola De Luca Andrea 《Journal of neurovirology》2003,9(1):47-53
Human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML) remains a relevant clinical problem even in the era of highly active antiretroviral therapy (HAART). Aims of the study were to analyze clinical and treatment-related features and the survival probability of PML patients observed within the Italian Registry Investigative Neuro AIDS (IRINA) during a 29-month period of HAART. Intravenous drug use, the presence of focal signs, and the involvement of white matter at neuroradiology increased the risk of having PML. A reduced probability of PML was observed when meningeal signs were reported. Patients starting HAART at PML diagnosis and previously naïve for antiretrovirals showed significantly higher 1-year probability of survival (.58), compared to those continuing HAART (.24), or never receiving HAART (.00). Higher CD4 cell count were associated with a higher survival probability (.45). At multivariate analysis, a younger age, higher CD4, starting HAART at PML diagnosis, the absence of previous acquired immunodeficiency syndrome (AIDS)-defining events, and the absence of a severe neurologic impairment were all associated with a reduced hazard of death. The use of cidofovir showed a trend towards a reduced risk of death. 相似文献
10.