Noninvasive measurement of the vital signs of cancer patients with a dual-path microbend fiber sensor

A novel dual-path microbend fiber optic sensor is designed for noninvasive measurement of respiratory rate (RR) and heart rate (HR) for cancer patients. The performance of the microbend fiber sensor is assessed in two groups of cancer patients, cancer patients with pain and without pain, ranging from eighteen to ninety-six years old in a daily observational measurement with the sensor mattress under the mattress of the clinical bed. All the patients received standard clinical monitoring for evaluating the accuracy of our measurement results. The results of our study showed good consistency in the experimental results of RR and HR between the dual-path fiber sensor we proposed and the hospital equipment with average errors of 3.60 beats per minute (bpm) and 1.02 respiration per minute (rpm) in HR and RR measurement in cancer patients with pain and 1.87bpm and 1.27rpm in HR and RR measurement in cancer patients without pain, respectively. In HR monitoring, the single path microbend fiber optic sensor has 8035 minutes of data with a false report rate of 19.09%, while the dual-path microbend fiber optic sensor has 6188 minutes of data with a false report rate of 12.87%. The dual-path sensor has a smaller false report rate compared with the single path sensor due to pre-judgments of data with path 1 and path 2. To our best knowledge, it is the first time to propose and demonstrate a dual-path sensor to reduce the false report rate for HR and RR measurements. The results of the Blend-Altman method showed great agreement between our sensor and hospital standard monitor in HR and RR measurements. The independent sample t-test indicates that the HR of cancer patients may be an effective way to judge whether or not they have cancer pain. Our noninvasive dual-path microbend fiber sensor also showed the advantages of an easy fabrication process, simple structure, and low false report rate.     

胰岛素泵强化治疗糖尿病患者的常见护理问题及对策

胰岛素泵强化治疗在快速稳定控制血糖的同时,能延缓糖尿病急、慢性并发症的发生、发展.但是由于胰岛素泵本身的特点以及使用管理不规范,造成病人生理、心理的不良影响及增加经济负担.现从胰岛素泵临床应用过程中出现的常见护理问题:患者因素(包括心理因素、经济因素)、局部皮肤感染、输注障碍、低血糖四个方面阐述其发生的原因及护理对策.     

甘草皂甙对大鼠腹腔细胞前列腺素E_2和cAMP水平的影响及对某些免疫功能的调节作用

甘草皂甙明显抑制由酵母聚糖及前列腺素E_2(PGE_2)引起的大鼠腹腔细胞内cAMP的上升。甘草皂甙复方降低由酵母聚糖刺激引起巨噬细胞释放的PGE_2,对小鼠巨噬细胞的移动无明显影响,但能减弱由植物血凝素诱导产生的巨噬细胞移动抑制因子(MIF)对巨噬细胞移动的抑制作用。用~(51)Cr标记调理的绵羊红细胞方法,证明低浓度甘草皂甙有刺激巨噬细胞吞噬的作用。本品对小鼠脾细胞增殖无显著影响。     

血清中丙二醛修饰低密度脂蛋白自身抗体的测定及意义

目的了解血清中丙二醛修饰低密度脂蛋白（ＭＤＡ－ＬＤＬ）自身抗体与动脉粥样硬化之间的关系。方法建立了血清中ａｕｔｏａｎｔｉ－ＭＤＡ－ＬＤＬ酶联免疫测定方法，并比较中老年（４５～６５岁）健康人、冠心病、高血脂和高血压病人血清中的ａｕｔｏａｎｔｉ－ＭＤＡ－ＬＤＬ水平。结果冠心病和高甘油三酯血症及混合型高血脂病人血清中的ＭＤＡ－ＬＤＬ自身抗体量明显高于健康人。结论血清中ａｕｔｏａｎｔｉ－ＭＤＡ－ＬＤＬ水平可能与冠心病、高脂血症有一定的内在联系     

威灵仙注射液关节腔离子导入对骨关节炎NO、SOD和PGE2的影响

目的:研究威灵仙注射液关节腔离子导入对骨关节炎NO、SOD和PGE2的影响。方法:新西兰兔40只,除保留10只作为正常组外,余均采用木瓜蛋白酶关节腔注射复制OA模型。造模4周后,根据模型动物关节肿胀度随机分为模型组、威灵仙组(Wlx组)、醋酸曲安奈德组(Qand组)。实验结束时,抽取各组动物关节滑液进行NO、SOD和PGE2的检测。结果:与模型组相比较,Wlx组和Qand组动物关节滑液中的NO和PGE2的含量显著降低(P0.05),SOD的含量升高(P0.05);但与Qand组相比,Wlx组动物关节滑液中NO和PGE2的抑制作用显著弱于Qand(P0.01),对升高SOD有微弱的优势。结论:威灵仙关节腔离子导入可能具有抑制炎症相关因子NO、PGE2的释放和增强SOD的活性来减缓OA的病变过程。     

社区“快乐之家”对精神分裂症患者康复效果的评估

目的 评估社区精神病患者日间康复照料机构"快乐之家"的康复效果.方法 对进入"快乐之家"的精神分裂症患者开展综合康复服务模式,并随访1年.在入组前、随访6个月及1年时采用简明精神病评定量表(BPRS)、社会功能缺陷量表(SDSS)、日常生活能力量表(ADL)、社会支持评价量表(SSRS)进行评估.共入组64例,完成随访61例.结果 经过"快乐之家"1年的综合康复治疗,61例患者的BPRS分值下降(基线:43±15,6个月:35±13,1年:30±6,F=17.89,P<0.001)、ADL分值也下降(基线:19±6,6个月:15±3,1年:15±3,F=16.96,P<0.001),SSRS分值提高(基线:27±5,6个月:31±6,1年:35±7,F=22.99,P<0.001).SDSS分值无明显变化.结论 社区"快乐之家"对促进社区精神病人的全面康复有着正性促进作用,该康复模式值得推广.     

Genetic Variation of the <Emphasis Type="Italic">Kalirin</Emphasis> Gene is Associated with ICAS in the Chinese Population

Alzheimer’s disease (AD) is a neurodegenerative disease that is imposing an increasing burden on society. Currently, AD is the leading cause of senile dementia worldwide. Despite the long existence of AD, there is lack of therapies for AD, suggesting that new and effective treatment strategy must be explored. At present, sirtuin pathway has attracted attention from the researchers due to its promising results in laboratory models of aging. In addition, our understanding in the roles of sirtuin 6 in AD has expanded. It has been identified to be involved in telomere maintenance, DNA repair, genome integrity, energy metabolism, and inflammation, which ultimately regulate life span. Recent findings also demonstrate that sirtuin 6 is lacking in AD patients, proposing that it can be a new potential therapeutic target in AD. Therefore, exploring on how sirtuin 6 is related in AD manifestation may accelerate the research of AD further and benefits future AD patients. Keeping that in mind, this review aims to highlight the possible roles of sirtuin 6 in AD manifestation.     

综合医院糖尿病联络护士小组的建立与运行

目的探讨综合医院糖尿病联络护士小组的建立及运行效果。方法以综合医院各护理单元内的1~2名护理骨干为主体建立糖尿病联络护士小组,有计划组织学习,开展活动,形成全院范围内糖尿病护理网络组织,为住院糖尿病患者提供专科性、连续性护理服务。结果糖尿病联络护士小组成立后,非糖尿病科护士的糖尿病理论知识和操作技能提高（P〈0.05或P〈0.01）;住院糖尿病患者健康知识掌握情况提高（P〈0.05或P〈0.01）。结论综合医院成立糖尿病联络护士小组能够提高非糖尿病科护士对糖尿病专科知识的掌握,提升专科护理质量,推动护理专科化发展。     

血清淀粉样蛋白A与不同糖耐量人群血管内皮功能的关系探讨

目的探讨不同糖耐量人群血清淀粉样蛋白A的水平,及与血管内皮功能的关系。方法59例患者根据OGIT试验分为3组：19例NGT、20例IGT和20例T2DM。分别检测血清淀粉样蛋白A、生化指标、肱动脉内皮依赖性舒张功能（FMD）和含服硝酸甘油后肱动脉内皮依赖性舒张功能（NID）。结果①SAA随着血糖的升高而升高,DM组的SAA较IGT组、NGT组明显升高（P〈0．01）,IGT组的SAA较NGT组升高（P〈0．05）。②FMD随着SAA的升高而下降,DM组的FMD较IGT组和NGT组明显降低（P〈0．01）,IGT组的FMD较NGT组降低（P〈0．05）。③Spearman相关分析显示SAA与FBG、HbA1c、TC均呈正相关（r值分别为0．63、0．48、0．59,P〈0．01）,与FMD呈显著负相关（r值为-0．62,P〈0．01）。结论SAA与血管内皮功能损害密切相关。     

以磷脂和载脂蛋白合成的人工表面活性物质

以二棕榈酰卵磷脂(DPPC)、磷脂酰甘油(PG)、脱脂高密度脂蛋白(AP-HDL)配制成人工表面活性物质,以其在体外的表面活性及对离体鼠肺压力-容量曲线的影响,与猪的天然PS作比较。结果显示,二者在体外均能降低表面张力,提高离体鼠肺的顺应性,在统计学上两者无显著性差异。因此,这种人工表面活性物质有可能成为肺表面活性物质替代治疗的一种制剂。