全文获取类型
收费全文 | 630篇 |
免费 | 48篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 53篇 |
妇产科学 | 13篇 |
基础医学 | 54篇 |
口腔科学 | 10篇 |
临床医学 | 63篇 |
内科学 | 152篇 |
皮肤病学 | 7篇 |
神经病学 | 34篇 |
特种医学 | 133篇 |
外科学 | 92篇 |
综合类 | 18篇 |
预防医学 | 28篇 |
眼科学 | 3篇 |
药学 | 32篇 |
肿瘤学 | 19篇 |
出版年
2022年 | 4篇 |
2020年 | 6篇 |
2019年 | 14篇 |
2018年 | 11篇 |
2017年 | 10篇 |
2016年 | 17篇 |
2015年 | 8篇 |
2014年 | 15篇 |
2013年 | 19篇 |
2012年 | 25篇 |
2011年 | 17篇 |
2010年 | 19篇 |
2009年 | 17篇 |
2008年 | 22篇 |
2007年 | 39篇 |
2006年 | 17篇 |
2005年 | 23篇 |
2004年 | 20篇 |
2003年 | 19篇 |
2002年 | 23篇 |
2001年 | 21篇 |
2000年 | 19篇 |
1999年 | 27篇 |
1998年 | 29篇 |
1997年 | 17篇 |
1996年 | 21篇 |
1995年 | 12篇 |
1994年 | 16篇 |
1993年 | 25篇 |
1992年 | 8篇 |
1991年 | 8篇 |
1990年 | 10篇 |
1989年 | 17篇 |
1988年 | 14篇 |
1987年 | 7篇 |
1986年 | 13篇 |
1985年 | 10篇 |
1984年 | 9篇 |
1981年 | 7篇 |
1980年 | 13篇 |
1978年 | 3篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1970年 | 6篇 |
1969年 | 7篇 |
1968年 | 6篇 |
1967年 | 5篇 |
1966年 | 3篇 |
排序方式: 共有715条查询结果,搜索用时 218 毫秒
1.
2.
3.
Adverse reaction to intravenous gadoteridol 总被引:1,自引:0,他引:1
4.
Ryan M McAdams Edward Mazuchowski Michael W Ellis Michael Rajnik 《Journal of perinatology》2005,25(10):677-679
Hospitalized neonates are commonly colonized soon after birth with Staphylococcus aureus. The majority of neonates do not develop infectious sequelae; however, premature neonates appear to be more susceptible to serious infections, such as pneumonia. We report a case of an extremely low birth weight infant who developed necrotizing pneumonia due to methicillin-resistant Staphylococcal aureus (MRSA). The MRSA isolate from this neonate is identical to the strains that have been causing primarily community-associated skin and soft tissue infections. The severe course of this patient may be attributed to the presence of the Panton-Valentine leukocidin gene, a well-known virulence factor leading to soft tissue and pulmonary infections. 相似文献
5.
Intestinal schistosomiasis japonica: CT-pathologic correlation 总被引:1,自引:0,他引:1
Lee RC; Chiang JH; Chou YH; Rubesin SE; Wu HP; Jeng WC; Hsu CC; Tiu CM; Chang T 《Radiology》1994,193(2):539
6.
Timothy R. McAdams Karl R. Knudsen Naveen Yalamanchi James Chang Stuart B. Goodman 《Knee surgery, sports traumatology, arthroscopy》2007,15(9):1144-1149
The purpose of this study was to compare the histological characteristics of an autogenous fascia lata graft alone and a fascia
lata graft combined with a deltoid flap in the reconstruction of rotator cuff tears. Ten New Zealand white rabbits were divided
into two groups. Infraspinatus tendon defects (1 × 1 cm) were created in each animal. Reconstruction consisted of either a
fascia lata graft alone or a fascia lata graft combined with a distally based deltoid flap. At 3 months, tissue harvest and
histological analysis was performed. Compared to the fascia lata graft alone, there was significantly increased remodeling
activity and neovascularization in the group that included a deltoid flap. Also, there was pronounced interdigitation at the
graft/flap interface in the latter group. A mutually beneficial relationship may exist when an autogenous fascial graft is
combined with a functional deltoid flap for reconstructing large rotator cuff defects. 相似文献
7.
8.
Gene conversion is a likely cause of mutation in PKD1 总被引:3,自引:0,他引:3
Watnick TJ; Gandolph MA; Weber H; Neumann HP; Germino GG 《Human molecular genetics》1998,7(8):1239-1243
Approximately 70% of the gene responsible for the most common form of
autosomal dominant polycystic kidney disease ( PKD1 ) is replicated in
several highly homologous copies located more proximally on chromosome 16.
We recently have described a novel technique for mutation detection in the
duplicated region of PKD1 that circumvents the difficulties posed by these
homologs. We have used this method to identify two patients with a nearly
identical cluster of base pair substitutions in exon 23. Since pseudogenes
are known to be reservoirs for mutation via gene conversion events for a
number of other diseases, we decided to test whether these sequence
differences in PKD1 could have arisen as a result of this mechanism. Using
changes in restriction digest patterns, we were able to show that these
sequence substitutions are also present in N23HA, a rodent-human somatic
cell hybrid that contains only the PKD1 homologs. Moreover, these changes
were also detected in total DNA from several affected and unaffected
individuals that did not harbor this mutation in their PKD1 gene copy. This
is the first example of gene conversion in PKD1 , and our findings
highlight the importance of using gene-specific reagents in defining PKD1
mutations.
相似文献
9.
Reye's syndrome simulacra in liver of mice after treatment with chemical agents and encephalomyocarditis virus 总被引:1,自引:0,他引:1
G Hug J Bosken K Bove C C Linnemann L McAdams 《Laboratory investigation; a journal of technical methods and pathology》1981,45(1):89-109
In children with Reye's syndrome, liver specimens exhibit the following characteristics: mitochondrial dysfiguration, fatty infiltration, decreased activity of carbamyl phosphate synthetase and of ornithine transcarbamylase, histochemically reduced activity of succinic dehydrogenase and cytochrome oxidase, and depletion of glycogen. We intended to create an animal model for Reye's syndrome by treating mice with encephalomyocarditis virus, and/or salicylate, fructose, Atlox, butylated hydroxytoluene, pentachlorophenol, and an equal mixture of butylated hydroxytoluene and monosodium stearate. Liver specimens were then examined for the listed characteristics as well as for the activity of argininosuccinic lyase, arginase, phosphorylase, and glucose-6-phosphatase. Results of interest in regard to the experimental intention were obtained in livers of mice treated with virus and Atlox (A) or virus and butylated hydroxytoluene (B). In these specimens, we found a significant reduction (p less than 0.05)--except for ornithine transcarbamylase (A)--to the following levels (in percentage of normal mean): carbamyl phosphate synthetase (A, 79 per cent; B, 57 per cent); ornithine transcarbamylase (A, 91 per cent; B, 75 per cent); glycogen (A, 26 per cent; B, 37 per cent). Simultaneous morphologic analysis of these liver specimens indicated mitochondrial dysfiguration, absence of dense granules, fatty infiltration, and normal activity of succinic dehydrogenase and cytochrome oxidase. The induction of Reye's syndrome-like features in mouse liver may be useful for the study of disease mechanisms and therapy. 相似文献
10.
Two types of phantoms were developed with which to evaluate the overall performance of digital subtraction angiography (DSA) systems. A dynamic phantom, called a "fish bone" phantom, consists of polyethylene tubes that simulate blood vessels with various lesions, such as stenoses, ulcers, and aneurysms. With this phantom, washout curves were obtained representing the relationship between iodine content and time. It will be useful for qualitative assessment of DSA images, evaluation of different image-processing schemes, and studies of blood flow analysis. A static phantom, called a "C-D" phantom, can be used for measurement of quantitative contrast-detail (C-D) diagrams and for daily monitoring of DSA systems. This was constructed of tubes of seven different diameters (2.15-0.28 mm) and 14 different concentrations of contrast medium (100%-1.1% Renografin-76 [meglumine and sodium diatrizoate]). The C-D diagrams were determined from an observer performance study using C-D phantom images obtained at four different DSA settings. 相似文献