全文获取类型
收费全文 | 223篇 |
免费 | 17篇 |
专业分类
儿科学 | 4篇 |
妇产科学 | 3篇 |
基础医学 | 49篇 |
口腔科学 | 4篇 |
临床医学 | 14篇 |
内科学 | 35篇 |
皮肤病学 | 2篇 |
神经病学 | 21篇 |
特种医学 | 8篇 |
外科学 | 48篇 |
综合类 | 4篇 |
预防医学 | 16篇 |
眼科学 | 7篇 |
药学 | 15篇 |
中国医学 | 1篇 |
肿瘤学 | 9篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 7篇 |
2020年 | 10篇 |
2019年 | 8篇 |
2018年 | 15篇 |
2017年 | 1篇 |
2016年 | 10篇 |
2015年 | 5篇 |
2014年 | 12篇 |
2013年 | 12篇 |
2012年 | 12篇 |
2011年 | 21篇 |
2010年 | 8篇 |
2009年 | 14篇 |
2008年 | 11篇 |
2007年 | 6篇 |
2006年 | 3篇 |
2005年 | 2篇 |
2004年 | 3篇 |
2003年 | 8篇 |
2002年 | 6篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1992年 | 10篇 |
1991年 | 6篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 1篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有240条查询结果,搜索用时 15 毫秒
1.
Epstein-Barr viral genome in lymph nodes from patients with Hodgkin''s disease may not be specific to Reed-Sternberg cells.
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A. Masih D. Weisenburger M. Duggan J. Armitage R. Bashir D. Mitchell R. Wickert D. T. Purtilo 《The American journal of pathology》1991,139(1):37-43
A possible etiologic role for Epstein-Barr virus (EBV) in Hodgkin's disease (HD) was investigated by probing for EBV genome in 52 biopsy specimens involved with HD and 43 hyperplastic lymph node specimens. Using dot-blot hybridization (Bam HIW probe), Southern blot hybridization (Xho I probe), and polymerase chain reaction analyses, 27%, 27%, and 58% of the nodes with HD were positive for EBV genome, respectively, as compared to 16%, 14%, and 43% in the hyperplastic lymph nodes. Clonal and nonclonal episomal EBV and linear replicating EBV genome were present in both conditions. Immunoglobulin heavy chain gene rearrangements were found in two clonal and two nonclonal EBV-positive HD cases, but not in the lymphoid hyperplasia cases. These findings and other recent reports showing EBV genome in benign lymphoid cells by in situ hybridization in Hodgkin's disease suggest that the characteristics of EBV infection in HD could be explained by the reactive cellular milieu, especially in the setting of defective immunity. The identification of EBV genome in Reed-Sternberg cells may, therefore, be a nonspecific phenomenon. 相似文献
2.
Suzena Masih Amita Moirangthem Shubha R. Phadke 《American journal of medical genetics. Part A》2020,182(2):293-295
Renpenning syndrome is one of the well‐characterized causes of X‐linked intellectual disability and is associated with microcephaly and various visceral malformations. Face is considered characteristic but the dysmorphism is subtle. Here we report an Indian adult with a very lean habitus, progressive atrophy of the upper back muscles, microcephaly, loss of cervical lordosis, and upper thoracic scoliosis. Using whole‐exome sequencing, a hemizygous deletion was identified in PQBP1 that leads to a frameshift and premature termination of translation. The loss of normal curvatures of cervical and upper thoracic spine due to muscular atrophy is a characteristic feature, though it may be age dependent. 相似文献
3.
4.
We present a rare case of a non-calcified pilomatricoma in a 67-year-old man. This tumor was extremely large in size, and
its location, in the lower extremity, was very unusual. The clinical, radiographic, and histopathological features are described
in detail. The role of magnetic resonance imaging (MRI) in the diagnosis of this entity is discussed. Definite internal reticulations
and septations were observed. A possible explanation for this observation is that the high signal intensity reticulations
may represent edematous stroma surrounding basaloid cells.
Received: 8 July 1999 Revision requested: 28 July 1999 Revision received: 10 September 1999 Accepted: 13 September 1999 相似文献
5.
Annika Senghaas Thomas Kremer Volker J. Schmidt Leila Harhaus Christoph Hirche Ulrich Kneser Amir K. Bigdeli 《Microsurgery》2019,39(2):174-177
Despite considerable advances in reconstructive surgery, massive abdominal wall defects continue to pose a significant surgical challenge. We report the case of a 72‐year‐old morbidly obese female patient with Clostridium septicum‐related gas gangrene of the abdominal wall. After multidisciplinary treatment and multiple extensive debridements, a massive full‐thickness defect (40 cm × 35 cm) of the right abdominal wall was present. The abdominal contents were covered with a resorbable mesh to prevent evisceration. Finally, the composite defect was successfully reconstructed through a contralateral extended free transverse rectus abdominis myocutaneus (TRAM) flap (50 cm × 38 cm). An arterio‐venous loop to the superficial femoral vessels using the great saphenous vein was necessary to allow the flap to reach the defect. Postoperatively, a minor wound healing disorder of the flap was successfully treated with split skin grafting. Six month after surgery, the patient presented with a completely healed flap coverage area and a small abdominal hernia without the need of further surgical revision. This case illustrates the use of a sliding free TRAM flap for closure of a massive abdominal wall defect. 相似文献
6.
Nargesi Shahin Abutorabi Ali Alipour Vahid Tajdini Masih Salimi Javad 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2021,35(4):829-839
Cardiovascular Drugs and Therapy - Abdominal aortic aneurysm (AAA) is a life-threatening condition which, in the absence of increasing diameter or rupture, often remains asymptomatic, and a... 相似文献
7.
J E Salvatore A C Edwards J N McClintick T B Bigdeli A Adkins F Aliev H J Edenberg T Foroud V Hesselbrock J Kramer J I Nurnberger M Schuckit J A Tischfield X Xuei D M Dick 《Translational psychiatry》2015,5(4):e558
Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case–control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumina Human 1M BeadChip. In total, all single-nucleotide polymorphisms (SNPs) accounted for 25% of the variance in AAB, although this estimate was not significant (P=0.09). Enrichment tests indicated that more significantly associated genes were over-represented in seven gene sets, and most were immune related. Our most highly associated SNP (rs4728702, P=5.77 × 10−7) was located in the protein-coding adenosine triphosphate-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1). In a gene-based test, ABCB1 was genome-wide significant (q=0.03). Expression analyses indicated that ABCB1 was robustly expressed in the brain. ABCB1 has been implicated in substance use, and in post hoc tests we found that variation in ABCB1 was associated with DSM-IV alcohol and cocaine dependence criterion counts. These results suggest that ABCB1 may confer risk across externalizing behaviors, and are consistent with previous suggestions that immune pathways are associated with externalizing behaviors. The results should be tempered by the fact that we did not replicate the associations for ABCB1 or the gene sets in a less-affected independent sample. 相似文献
8.
Objective:Falls are one of the life events leading to injury and in serious cases cause high morbidity and mortality.This research was conducted to determine the fall incidence among female population ... 相似文献
9.
Florian Falkner MD Benjamin Thomas MD Gabriel Hundeshagen MD MMS Gerhard Wittenberg MD Björn Bliesener MD Amir K. Bigdeli MD Ulrich Kneser MD 《Microsurgery》2020,40(8):911-915
We report the case of a 67-year old male with necrotizing fasciitis after injection of the glenohumeral joint. After extensive debridement a massive defect from the left hip joint to the left upper arm, exposing ribs, scapula, axillary vessels and brachial plexus (45 × 40 cm) was present. Reconstruction was performed with a conjoined right myocutaneous tensor fasciae lata/vastus lateralis flap and a left myocutaneous vastus lateralis flap in combination with an arteriovenous loop originating from the axillary vessels using the greater saphenous vein. Revisional surgeries were necessary including ribs resection and flap re-advancements. Due to multiorganic failure invasive ventilation, renal replacement- and extensive transfusion therapy was required. After 241 days the patient was discharged for rehabilitation. At the 12 months follow-up wounds were sufficiently closed without the need for further intervention. This case illustrates that immediate diagnosis followed by an aggressive multidisciplinary treatment approach is crucial for the patient survival. 相似文献