全文获取类型
收费全文 | 10153篇 |
免费 | 745篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 91篇 |
儿科学 | 235篇 |
妇产科学 | 299篇 |
基础医学 | 1263篇 |
口腔科学 | 483篇 |
临床医学 | 1020篇 |
内科学 | 2333篇 |
皮肤病学 | 213篇 |
神经病学 | 748篇 |
特种医学 | 346篇 |
外科学 | 1107篇 |
综合类 | 108篇 |
一般理论 | 7篇 |
预防医学 | 982篇 |
眼科学 | 132篇 |
药学 | 633篇 |
中国医学 | 39篇 |
肿瘤学 | 880篇 |
出版年
2023年 | 68篇 |
2022年 | 148篇 |
2021年 | 283篇 |
2020年 | 200篇 |
2019年 | 263篇 |
2018年 | 312篇 |
2017年 | 205篇 |
2016年 | 261篇 |
2015年 | 278篇 |
2014年 | 385篇 |
2013年 | 458篇 |
2012年 | 728篇 |
2011年 | 710篇 |
2010年 | 375篇 |
2009年 | 362篇 |
2008年 | 564篇 |
2007年 | 619篇 |
2006年 | 588篇 |
2005年 | 506篇 |
2004年 | 514篇 |
2003年 | 515篇 |
2002年 | 427篇 |
2001年 | 174篇 |
2000年 | 179篇 |
1999年 | 147篇 |
1998年 | 67篇 |
1997年 | 63篇 |
1996年 | 64篇 |
1995年 | 51篇 |
1994年 | 42篇 |
1993年 | 46篇 |
1992年 | 79篇 |
1991年 | 80篇 |
1990年 | 83篇 |
1989年 | 85篇 |
1988年 | 71篇 |
1987年 | 74篇 |
1986年 | 73篇 |
1985年 | 60篇 |
1984年 | 63篇 |
1983年 | 49篇 |
1982年 | 42篇 |
1981年 | 35篇 |
1980年 | 38篇 |
1979年 | 31篇 |
1977年 | 41篇 |
1976年 | 30篇 |
1971年 | 35篇 |
1970年 | 34篇 |
1967年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Background
Total knee arthroplasty is a treatment option for debilitating arthritis. In the postoperative period, patients experience moderate to severe pain affecting the rehabilitation, hospital stay, and patient satisfaction. This study aims at utilizing current best evidence to determine whether adductor canal block (ACB) or periarticular injection (PAI) is a better modality for managing short-term postoperative pain and opioid consumption.Methods
Embase, MEDLINE, HealthStar, Emcare, and PubMed were searched for randomized controlled trials from 1946 to August 2018, for literature addressing the comparison of ACB and PAI for pain management in the setting of total knee arthroplasty. A systematic review and meta-analysis were performed.Results
Six studies were included in our meta-analysis. When examining the combined visual analog scale (VAS) pain values for each group, analysis demonstrated greater reduction in scores for the PAI group, and the difference was statistically significant (P = .001). When comparing the VAS scores of subgroups analyzed at specific periods in time, there was a trend toward lower VAS scores in subgroups analyzed at 24 hours and 48 hours postoperatively (at rest and at movement) in the PAI group. Overall opioid consumption was lower in the PAI group, with demonstrated statistical significance (P = .03). When comparing the postoperative subgroups, there was a trend toward decreased opioid use in the PAI group, with 13.25% less opioid use at 48 hours and 9.5% less opioid use at 24 hours.Conclusion
PAI could significantly improve postoperative pain and opioid consumption when compared with ACB. Additional, high-quality studies are required to further address this topic. 相似文献2.
3.
Chris Giles 《Canadian Medical Association journal》2002,167(7):786-787
4.
5.
Rosangela Saga Kamikawa Marlene Fenyo Pereira Angela Fernandes Maria Inês Meurer 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2006,101(3):374-378
OBJECTIVE: To determine the location in soft tissues of the calcifications, similar to calcified carotid atheromas, that can be observed radiographically in the cervical region in panoramic radiographs. STUDY DESIGN: In each anatomic cadaver specimen preserved in formol, consisting of the head and neck, radiopaque spheres (made from gutta-percha) were positioned in anatomic structures of the cervical region that can be sites of calcification. For each anatomic structure marked in this way, panoramic radiography was performed, consisting of 17 radiographs. The images obtained were analyzed by 24 examiners who indicated which radiographs, in their opinion, presented the radiopaque reference projected in the region of bifurcation of the carotid artery. Analysis of 2 proportions from agreement and disagreement was used to determine radiopacities that could be confused in panoramic radiographs with calcified atheromas in the carotid artery. RESULTS: The results showed that 75% (18) of the examiners correctly indicated the reference in the bifurcation of the carotid artery and 79.2% (19) indicated a triticeous cartilage as calcified atheroma of the carotid artery. CONCLUSIONS: Calcified atheromas of the carotid artery are not the only features that can produce radiopaque images lateral to the panoramic radiograph; the presence of calcification in the triticeous cartilage also can induce an erroneous diagnosis of calcified carotid atheroma. 相似文献
6.
Hilary Eadon Marlene Rose Richard O'Neill Neil Leaver Magdi Yacoub 《Transplant international》1995,8(1):35-40
Pharmacokinetic profiles were obtained for 16 heart or lung recipients following the administration of identical doses of cyclosporin as oral solution and capsules on consecutive days. A comparison of pharmacokinetic parameters (AUC, Cmax, Cmin and tmax) showed that there were no significant differences between the two formulations except for the tmax, which was significantly longer for the capsules. The mean variation in day-to-day trough levels produced by the two different forms was 25.6%. A retrospective study was carried out of consecutive cyclosporin levels in patients at steady state on oral solution. The mean variation in day-to-day trough levels was 32.3%. This was not significantly different from the variation in consecutive trough levels seen in the oral solution/capsule comparison. This study shows that cyclosporin capsules can be substituted for oral solution without causing acute changes in cyclosporin blood levels, and that the pharmacokinetics of the two formulations are similar.This work was carried out in partial fulfillment of the requirements for the Master of Science Degree in Clinical Pharmacy, University of London 相似文献
7.
A rural hospital elective in a diploma nursing program is described. A need and opportunity for this unique practicum was identified in a Canadian province where one-third of the acute care beds are in hospitals of under 100 beds, located primarily in towns outside of metropolitan areas. The six week course offers students 35 hours of classroom content focusing on rural health care concepts plus a 150 hour practicum in one of three participating hospitals. The course is seen as unique in that it focuses on rural health care and is offered within the context of a diploma nursing program. Vive student outcomes are identified: awareness of the differences between rural and urban health care; integration of knowledge and experience from previous nursing courses as it relates to the rural context; increasing understanding of how rural population groups affect health care delivery; awareness of rural employment opportunities; and, preparation for the graduate role. A shared vision and collaborative effort on the part of the School of Nursing, the rural hospitals and the host communities has been necessary to establish and maintain such a course. 相似文献
8.
P E Marchiori A J Duarte M I Birolli C A Figueiredo M Scaff J L De Assis 《Arquivos de neuro-psiquiatria》1988,46(3):248-253
A significant decline of CD3 cell detected by rosettes and a significant increased of B cell populations were observed. The total CD3+, helper CD4+ and suppressor CD8+ T-cell subsets showed no significant variation em relation to sex, age thymectomy and corticotherapy by monoclonal antibodies. 相似文献
9.
Intravenous captopril in congestive heart failure 总被引:1,自引:0,他引:1
S Ahmad T D Giles L E Roffidal Y Haney M B Given G E Sander 《Journal of clinical pharmacology》1990,30(7):609-614
Hemodynamic and neurohumoral effects of intravenous captopril were studied in ten patients with severe chronic congestive heart failure (NYHA Functional Class III and IV). Incremental bolus doses of captopril, titrated to a maximum cumulative dose of 15 mg, were given at 10-minute intervals. Systemic arterial pressure, mean pulmonary capillary wedge pressure, systemic vascular resistance, mean pulmonary artery pressure, and heart rate decreased (P less than .05). Cardiac index and stroke volume index increased (P less than .05). Maximum hemodynamic effects occurred after cumulative doses of 7 mg and were seen within 30 minutes after initiation of therapy; responses persisted for 30-90 minutes after the last dose. Plasma renin activity increased, and plasma atrial natriuretic factor concentration decreased. No adverse effects were observed with the use of intravenous captopril. Thus, intravenous captopril produces rapid and favorable hemodynamic improvement in advanced heart failure patients. 相似文献
10.
Elsa J. Brochmann Murray Samuel S. Murray Mario Grisanti Maria Eugenia L. Duarte Marshall R. Urist 《Journal of orthopaedic research》1997,15(4):585-592
The SENCAR (sensitive to carcinogenesis) mouse is a unique tool for investigating the interaction between a specific defect in intracellular signaling, dietary calcium, and metabolic bone disease. The SENCAR mouse was developed by selective breeding for enhanced sensitivity to two-stage carcinogenesis. Its major genetic defect, which renders it exquisitely sensitive to stimulation with diacylglycerol or phorbol esters, is in the regulatory domain of protein kinase C, one of the primary intracellular mediators of hormonal effects. At sexual maturity, SENCAR mice are large and have big bones, but our previous pharmacokinetic studies showed that they accumulate lesscalcium under normal conditions and lose more calcium under adverse conditions than do other, standard strains of mice. To histologically define the effect of low dietary calcium on bone metabolism, we performed histomorphometric analysis of tetracycline-labeled sections of femoral bone from male SENCAR mice maintained on calcium-sufficient and calcium-deficient diets during the critical period from 10 to 14 weeks of age. The bone volume, absolute osteoid volume, and mineral apposition rate were lower at 14 than at 10 weeks of age in SENCAR mice fed 0.02 or 0.6% calcium diets. Calcium deficiency increased the architectural disarray and the probability of observing focal discontinuities in the growth plate. Thus, characteristic features of impaired bone metabolism (low bone volume and apposition rate) develop early in SENCAR mice and are exacerbated by low dietary calcium. Detailed examinations of the histology and biochemistry of SENCAR mouse bone will provide insights into the mechanisms by which specific defects in the signal transduction of protein kinase C contribute to impaired bone metabolism. 相似文献