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1.
Catherine Neauport-Sautes Daniele Silvestre Marie-Gabrielle Niccolai F. M. Kourilsky J. P. Levy 《Immunology》1972,22(5):833-845
The localization of HL-A histocompatibility antigens at the surface of human lymphocytes in electron microscopy has been studied using hybrid antibodies to bind electron-dense particles (ferritin and plant viruses) to anti-HL-A antibody. A discontinuous distribution of the markers is observed at the cell surface, which is identical with that described for H-2 antigens on mouse lymphocytes with the same technique. Double labelling experiments suggest that the areas of the cell surface where HL-A antigens are detected contain also the heterologous lymphocyte antigens detected by an anti-thymocyte serum and that HL-A antigens are not renewed at a detectable level during the period of the labelling procedure in the areas of the cell surface which are not labelled primarily with ferritin-anti-IgG-anti-HL-A complexes. The interpretation of the discontinuous labelling of HL-A antigens with direct immunoferritin techniques is discussed. 相似文献
2.
Ramsay E. Beveridge Heidi Ackerly Wallweber Avi Ashkenazi Maureen Beresini Kevin R. Clark Paul Gibbons Elise Ghiro Susan Kaufman Alexandre Larive Melissa Leblanc Jean-Philippe Leclerc Alexandre Lemire Cuong Ly Joachim Rudolph Jacob B. Schwarz Sanjay Srivastava Weiru Wang Liang Zhao Marie-Gabrielle Braun 《ACS medicinal chemistry letters》2020,11(12):2389
Amino-quinazoline BRaf kinase inhibitor 2 was identified from a library screen as a modest inhibitor of the unfolded protein response (UPR) regulating potential anticancer target IRE1α. A combination of crystallographic and conformational considerations were used to guide structure-based attenuation of BRaf activity and optimization of IRE1α potency. Quinazoline 6-position modifications were found to provide up to 100-fold improvement in IRE1α cellular potency but were ineffective at reducing BRaf activity. A salt bridge contact with Glu651 in IRE1α was then targeted to build in selectivity over BRaf which instead possesses a histidine in this position (His539). Torsional angle analysis revealed that the quinazoline hinge binder core was ill-suited to accommodate the required conformation to effectively reach Glu651, prompting a change to the thienopyrimidine hinge binder. Resulting analogues such as 25 demonstrated good IRE1α cellular potency and imparted more than 1000-fold decrease in BRaf activity. 相似文献
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Menu-Branthomme A Rubino C Shamsaldin A Hawkins MM Grimaud E Dondon MG Hardiman C Vassal G Campbell S Panis X Daly-Schveitzer N Lagrange JL Zucker JM Chavaudra J Hartman O de Vathaire F 《International journal of cancer. Journal international du cancer》2004,110(1):87-93
Soft tissue sarcoma (STS) is one of the most frequent second primary cancer that occurs during the first 20 years following treatment for a solid cancer in childhood. Our aim was to quantify the risk of STS as a second malignant neoplasm and to investigate its relationship with radiotherapy and chemotherapy. A cohort study of 4,400 3-year survivors of a first solid cancer diagnosed during childhood in France or the United Kingdom, between 1942 and 1985, was followed 15 years on average. In a partially nested case-control study, we matched 25 cases of STS and 121 controls for sex, type of first cancer, age at first cancer and duration of follow-up. Sixteen STS occurred in the cohort, as compared to 0.3 expected from the general population (Standardized Incidence Radio, SIR = 54 (95%CI: 34-89)). The SIR was 113 (95% CI: 62-185) after chemotherapy plus radiotherapy (13 STS), whereas it was 28 (95%CI: 2-125) after chemotherapy alone (1 STS) and 19 (95%CI: 3-60) after radiotherapy alone (2 STS). After adjustment for treatment, there was no evidence of variation in the annual excess of incidence or in the SIR with either age at first cancer or time since 1st cancer. In the case-control study, the risk of a STS was increased with the square of the dose of radiation to the site of STS development and with the administration of Procarbazine. The increased risk of soft tissue sarcoma that occurred after childhood cancer is independently related to exposure to radiotherapy and Procarbazine. A closer surveillance of children treated with this treatment combination is strongly recommended. 相似文献
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GABRIEL DUC Zurich 《Paediatric and perinatal epidemiology》2002,16(3):192-193
6.
Anne-Laure Adra Marie-Gabrielle Vigue Fabienne Dalla Vale Lydia Ichay Pierre Raynaud Aude Mariani Denis Morin 《Pediatric nephrology (Berlin, Germany)》2010,25(9):1765-1769
Mycoplasma pneumoniae-associated nephritis has been reported in children with various pathological findings. It nevertheless remains an uncommon
disease and, within this clinical context, endo-and extracapillary glomerulonephritis in a child has never been described.
We report here a case of a 3-year-old girl diagnosed with severe crescentic glomerulonephritis associated with M. pneumoniae infection who presented with nephrotic syndrome and impaired renal function. The serum C3 complement level was initially
low but returned to normal after 1 month. Two courses of three methylprednisolone pulses were administered in association
with plasmapheresis and, secondarily, mycophenolate mophetil. This treatment regimen led to disease remission and a favorable
renal outcome at the 6-month follow-up. However, the treatment guidelines in this situation remain debatable. 相似文献
7.
Atypical thyrotropin-secreting pituitary microadenoma revealed by severe osteoporosis in a young man
Alexis de Rougemont Marie-Gabrielle Mourot Jean-Paul Riou 《Journal of bone and mineral metabolism》2009,27(4):513-518
For 10 years, a young man was followed for a severe osteoporosis associated with a considerable reduction in height and a
massive weight loss. The constant increase of signs of tissue impregnation with thyroid hormones and the molar ratios of α-TSH
suggested an inappropriate secretion of thyrotropin. Magnetic resonance imaging finally revealed a thyrotropic microadenoma
of the pituitary gland. This case gives some new additional information on thyrotropin-induced osteoporosis. To our knowledge
such a case has never been reported in the literature. 相似文献
8.
A. Forsby A.K. Bal-Price A. Camins S. Coecke N. Fabre H. Gustafsson P. Honegger A. Kinsner-Ovaskainen M. Pallas V. Rimbau E. Rodríguez-Farré C. Suñol J.A. Vericat M.G. Zurich 《Toxicology in vitro》2009,23(8):1564-1569
The objective of the EU funded integrated project “ACuteTox” is to develop a strategy in which general cytotoxicity, together with organ-specific endpoints and biokinetic features, are taken into consideration in the in vitro prediction of oral acute systemic toxicity. With regard to the nervous system, the effects of 23 reference chemicals were tested with approximately 50 endpoints, using a neuronal cell line, primary neuronal cell cultures, brain slices and aggregated brain cell cultures. Comparison of the in vitro neurotoxicity data with general cytotoxicity data generated in a non-neuronal cell line and with in vivo data such as acute human lethal blood concentration, revealed that GABAA receptor function, acetylcholine esterase activity, cell membrane potential, glucose uptake, total RNA expression and altered gene expression of NF-H, GFAP, MBP, HSP32 and caspase-3 were the best endpoints to use for further testing with 36 additional chemicals. The results of the second analysis showed that no single neuronal endpoint could give a perfect improvement in the in vitro–in vivo correlation, indicating that several specific endpoints need to be analysed and combined with biokinetic data to obtain the best correlation with in vivo acute toxicity. 相似文献
9.
Toufektsian MC Robbez-Masson V Sanou D Jouan MG Ormezzano O de Leiris J Boucher F 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2008,22(6):437-442
Background Reperfusion of the ischemic myocardium is associated with increased inflammatory processes that can exert deleterious effects
and therefore contribute to cardiac dysfunction. The aim of the present study was to verify whether the administration of
sTNFR-Fc, a scavenger of the pro-inflammatory cytokine TNF-α, at the time of reperfusion would protect against myocardial
infarction and reduce the severity of early mechanical dysfunction.
Methods Male Wistar rats were subjected to 60 min coronary occlusion followed by reperfusion. A bolus of sTNFR-Fc (10 μg/kg, i.v.) (MI + sTNFR-Fc group) or a placebo (MI group) was injected prior to reperfusion. Cardiac geometry was assessed by echocardiography
1, 3 and 7 days after reperfusion. Eight days after reperfusion, left ventricular (LV) function was evaluated under basal
conditions and during an experimental challenge of volume overload. Finally, infarct size was measured after euthanasia.
Results sTNFR-Fc administration markedly reduced infarct size (P < 0.01) and decreased LV dilation as assessed by the echocardiographic measurement of the LV end diastolic area, 7 days post-MI
(P < 0.01). Moreover, LV end-diastolic pressure was significantly preserved by sTNFR-Fc 1 week after myocardial infarction,
under basal conditions (P < 0.05) as well as during cardiac overload (P < 0.05).
Conclusion A single administration of sTNFR-Fc at the time of reperfusion after myocardial infarction is able to limit infarct size and
to reduce early LV diastolic dysfunction in rats. These findings suggest that intravenous neutralization of TNF-α during surgical
cardiac reperfusion might improve the outcome of myocardial infarction in humans. 相似文献
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Francesca Damiola Inès Schultz Laure Barjhoux Valérie Sornin Marie-Gabrielle Dondon Séverine Eon-Marchais Morgane Marcou Olivier Caron Marion Gauthier-Villars Antoine de Pauw Elisabeth Luporsi Pascaline Berthet Capucine Delnatte Valérie Bonadona Christine Maugard Pascal Pujol Christine Lasset Michel Longy Yves-Jean Bignon Jean-Pierre Fricker Nadine Andrieu Olga M. Sinilnikova Dominique Stoppa-Lyonnet Sylvie Mazoyer Danièle Muller The GENESIS Study Investigators 《Breast cancer research and treatment》2015,152(3):463-476