全文获取类型
收费全文 | 1039篇 |
免费 | 42篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 6篇 |
妇产科学 | 13篇 |
基础医学 | 156篇 |
口腔科学 | 13篇 |
临床医学 | 44篇 |
内科学 | 109篇 |
皮肤病学 | 44篇 |
神经病学 | 297篇 |
特种医学 | 42篇 |
外科学 | 81篇 |
综合类 | 43篇 |
一般理论 | 1篇 |
预防医学 | 43篇 |
眼科学 | 3篇 |
药学 | 151篇 |
肿瘤学 | 24篇 |
出版年
2021年 | 13篇 |
2020年 | 9篇 |
2019年 | 18篇 |
2018年 | 19篇 |
2017年 | 16篇 |
2016年 | 19篇 |
2015年 | 16篇 |
2014年 | 30篇 |
2013年 | 48篇 |
2012年 | 49篇 |
2011年 | 48篇 |
2010年 | 39篇 |
2009年 | 19篇 |
2008年 | 44篇 |
2007年 | 38篇 |
2006年 | 37篇 |
2005年 | 38篇 |
2004年 | 33篇 |
2003年 | 31篇 |
2002年 | 40篇 |
2001年 | 20篇 |
2000年 | 27篇 |
1999年 | 31篇 |
1998年 | 10篇 |
1997年 | 9篇 |
1996年 | 11篇 |
1994年 | 10篇 |
1993年 | 8篇 |
1992年 | 22篇 |
1991年 | 21篇 |
1990年 | 24篇 |
1989年 | 28篇 |
1988年 | 16篇 |
1987年 | 22篇 |
1986年 | 20篇 |
1985年 | 20篇 |
1984年 | 18篇 |
1983年 | 17篇 |
1982年 | 12篇 |
1981年 | 7篇 |
1979年 | 11篇 |
1978年 | 6篇 |
1977年 | 8篇 |
1976年 | 6篇 |
1975年 | 6篇 |
1974年 | 9篇 |
1973年 | 6篇 |
1972年 | 9篇 |
1971年 | 6篇 |
1970年 | 8篇 |
排序方式: 共有1082条查询结果,搜索用时 15 毫秒
1.
Infantile Digital Fibroma Treated With Mohs Micrographic Surgery 总被引:2,自引:0,他引:2
John G. Albertini MD Maj USAF MC Michael Jude Welsch MD CPT USA MC Leo A. Conger MD LTC USA MC Lester F. Libow MD COL USA MC Dirk M. Elston MD COL USA MC 《Dermatologic surgery》2002,28(10):959-961
BACKGROUND: Infantile digital fibroma (IDF) is a rare benign fibrous tumor of childhood that frequently recurs despite local excision. Conservative, nonsurgical management may result in regression and/or joint deformity. OBJECTIVE: To describe the histologic features of IDF and discuss a case excised using Mohs micrographic surgery (MMS). METHODS: Case report and review of the clinical, histologic, and ultrastructural features. RESULTS: Characteristic inclusion bodies of actin were identified with hematoxylin and eosin, Masson's trichrome, and rapid actin immunostain. The tumor was debulked and the majority was removed after one stage of MMS, except where the deep margin approached the joint space. The defect healed by secondary intention. At 2 years the patient had no recurrence or functional joint deformity. CONCLUSION: MMS is a surgical treatment option for IDF. 相似文献
2.
CEEG mapping in drug-free schizophrenics. Differences from healthy subjects and changes induced by haloperidol treatment. 总被引:1,自引:0,他引:1
A topographic CEEG investigation was carried out in 20 drug-free, DSM-IIIR diagnosed schizophrenics and in a group of matched healthy controls. The effects of acute and chronic haloperidol treatment were then assessed in the patient group. On the baseline recording, schizophrenics showed a widespread increase in delta, theta 1 and beta 3 amplitude. Acute haloperidol administration produced a decrease in delta and an increase in slow beta amplitude. After 28 days of treatment, delta and fast beta were reduced while theta 2 and alpha 1 were increased. CEEG abnormalities in schizophrenic subjects appear, therefore, to be reduced by chronic neuroleptic treatment. 相似文献
3.
4.
5.
M. Maj 《Acta psychiatrica Scandinavica》1988,78(2):182-187
The course and outcome of cycloid psychotic disorder was explored by means of a prospective three-year follow-up of a sample of patients fulfilling the diagnostic criteria for the disorder provided by Perris & Brockington, compared to patients with a diagnosis of affective or schizoaffective disorder. The most striking difference between cycloids and affectives was the lack of manic episodes during the follow-up period in the former group. Moreover, the mean age at onset was lower in cycloids. No difference between these patient groups was observed with regard to outcome. Compared to schizoaffectives, cycloids showed several differences in the clinical picture during the index episode, and their symptomatological pattern was more consistent from one episode to another during the follow-up. Moreover, the outcome of cycloids was significantly more favourable than that of schizodepres-sives. 相似文献
6.
7.
In 1999, mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2) were first reported in patients with Rett syndrome (RTT). The MECP2 gene is located at Xq28 and consists of 4 exons. About 80-90 % of the classic RTT patients harbor mutations in the coding region of MECP2, while the molecular cause is unknown in the remaining 10-20%. Several groups have searched for large rearrangements within the MECP2 and the results indicate that a fraction of MECP2-negative RTT cases has large deletions of the MECP2. In this study we have used the Multiplex Ligation-dependent Probe Amplification (MLPA) technique to screen 45 RTT patients, who have previously been tested negative for mutations in the coding region of MECP2. The MECP2-MLPA is a semi-quantitative multiplex PCR approach. It determines the relative number of copies of each MECP2 exon. With this approach we detected seven RTT patients with genomic deletions and further characterized the deletions using real time quantitative PCR (qPCR) and long-range PCR. The seven patients were given a severity score and their X chromosome inactivation profiles were determined in order to identify a possible genotype-phenotype correlation. The results from this study indicate that large deletions in MECP2 cause classic RTT. 相似文献
8.
In 331 patients with the diagnosis of multiple myeloma in 4 cases proliferation of plasma cells was associated with synthesis of a monoclonal IgM. In 3 of these cases coexistence was noted of features typical of multiple myeloma and Waldenstr?m's macroglobulinaemia. In the clinical picture in two of these cases sings of blood hyperviscosity prevailed. These patients showed impairment of plasma clotting factors. The count of T and B cells in blood and the adherence and phagocytic activity of monocytes were not abnormal. The ultrastructural pattern of plasma cells in bone marrow was similar to that observed in classical cases of IgG or IgA multiple myeloma. In one case of lymphoplasmocytic proliferation with leucocytosis over 100 x 10(9)/l immunoelectroscopic examination of bone marrow cells demonstrated a formidable accumulation of the heavy chain of mu immunoglobulin in the cytoplasm of lymphoplasmacytes. In the serum and urine no monoclonal protein was found. In this case compression of vertebral bodies Th7 and L2 occurred. 相似文献
9.
Ignacio Prieto Charles Tease Nieves Pezzi José M. Buesa Sagrario Ortega Leonor Kremer Alicia Martínez Carlos Martínez-A Maj A. Hultén José L. Barbero 《Chromosome research》2004,12(3):197-213
Cohesins are chromosomal proteins that form complexes involved in the maintenance of sister chromatid cohesion during division of somatic and germ cells. Three meiosis-specific cohesin subunits have been reported in mammals, REC8, STAG3 and SMC1 beta; their expression in mouse spermatocytes has also been described. Here we studied the localization of different meiotic and mitotic cohesin components during prophase I in human and murine female germ cells. In normal and atretic human fetal oocytes, from leptotene to diplotene stages, REC8 and STAG3 colocalize in fibers. In murine oocytes, SMC1beta, SMC3 and STAG3 are localized along fibers that correspond first to the chromosome axis and then to the synaptonemal complex in pachytene. Mitotic cohesin subunit RAD21 is also found in fibers that decorate the SC during prophase I in mouse oocytes, suggesting a role for this cohesin in mammalian sister chromatid cohesion in female meiosis. We observed that, unlike human oocytes, murine synaptonemal complex protein SYCP3 localizes to nucleoli throughout prophase I stages, and centromeres cluster in discrete locations from leptotene to dictyate. At difference from meiosis in male mice, the cohesin axis is progressively lost during the first week after birth in females with a parallel destruction of the axial elements at dictyate arrest, demonstrating sexual dimorphism in sister chromatid cohesion in meiosis. 相似文献
10.
Palmiero Monteleone Alfonso Tortorella Eloisa Castaldo Mario Maj 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2006,(1):7-9
The pathophysiological mechanisms underlying binge eating disorder (BED) are poorly understood. There is evidence that abnormalities in brain serotonin (5HT) play an important role in binge eating behavior, therefore genes involved in 5HT transmission, such as the 5HT transporter (5HTT) gene, may contribute to the biological vulnerability to BED. We examined whether the polymorphism of the promoter of the 5HTT gene, consisting of a long (L) and a short (S) variant, was associated with BED. Seventy-seven obese or non-obese women with BED, and 61 normal weight control women were genotyped at the 5HTT gene linked polymorphism (5HTTLPR). Statistical analysis showed that both the LL genotype and the L allele of the 5HTTLPR were significantly more frequent in BED subjects. Moreover, the L allele was associated with a moderate but significant risk to develop BED (OR = 2.01, CI = 1.33-3.57). Although these data should be regarded as preliminary because of the small size of our sample, they suggest that the 5HTTPRL may contribute to the genetic susceptibility to BED. 相似文献