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排序方式: 共有1619条查询结果,搜索用时 15 毫秒
1.
Votteler T. P. Lipsky K. 《世界核心医学期刊文摘》2006,2(2):31-31
背景/目的:从1978-2000年,有10对联体双胞胎成功接受了手术分离,结果14人存活。其中6对是因为他们的联体同胞死亡或濒临死亡而接受紧急分离手术。剩余的4对,每对至少一个同胞接受至少一次的急诊手术后,才接受联体分离手术。方法:对这一独特的队列进行包含6个项目的问卷调查。问题的设计是开放式的,为父母/家庭提供有关信息的最大机会。对每个家庭就相同的问题也进行了当面的问卷调查。医师询问了与身体健康和疾病相关的一些问题。而社会工作询问了与发育、教育、社会心理和家庭功能相关的问题。结果:前面提及的14人存活的双胞胎中,4人大学毕业,1人于1981年完成中学学业,剩余9人正在上学。14人在最初的手术后,还需要接受再次手术,尤其是需要矫正泌尿系统、畸形、神经外科和小儿外科的问题。结论:通过超声检查对联体双胎进行宫内诊断,可以使医师和胎儿父母在孕早期决定在终止妊娠时是进行双胎分离还是保全其中一个。这些病例报道通过描述14例手术存活的长期体格检查和心理学检查结果,为医师和父母在关键时刻做出决定提供了另外有助的依据。 相似文献
2.
E D Endean S K Mukhopadhyay L K Fung J L Cronenwett J C Stanley S M Lindenauer 《The Journal of surgical research》1986,40(1):49-54
Basal isolated canine paw blood flow was equally distributed between arteriovenous anastomosis (AVA) and capillary circulations. Norepinephrine decreased AVA flow by 92% and capillary flow by 41%. Dopamine significantly reduced AVA flow by 94% compared to baseline with a 37% reduction in capillary flow. However, with alpha-adrenergic blockade dopamine decreased AVA flow 66% while capillary flow increased 42%. Isoproterenol increased capillary flow almost twofold and appeared to decrease AVA flow, although the latter was statistically insignificant. Differential effects of adrenergic and dopaminergic agonists on canine paw AVA and capillary blood flow suggest the existence of independent regulation of these components of the microcirculation. 相似文献
3.
This case describes a rare complication of prostaglandin analogue eye drops used for treatment of primary open angle glaucoma. Though increase in the number, size and pigmentation of eyelashes is well‐known, this case shows extensive hair growth in malar region, which can be unacceptable. This complication can be one of the causes of discontinuation of prostaglandin analogue therapy. 相似文献
4.
Uday Mukhopadhyay Ashutosh Pal Juri G Gelovani William Bornmann Mian M Alauddin 《Applied radiation and isotopes》2007,65(8):941-946
Radiosynthesis of 2'-deoxy-2'-[(18)F]-fluoro-5-methyl-1-beta-L-arabinofuranosyluracil ([(18)F]-L-FMAU) is reported. Compound 1 was synthesized and converted to 2-triflate 2. Compound 3 was prepared from 2 using tetrabutylammonium[(18)F]fluoride, converted to 4, and then coupled with 5. The crude product was hydrolyzed, and purified by HPLC to obtain 7a. The radiochemical yield of [(18)F]-L-FMAU was 26% decay corrected (d.c.) in four runs with radiochemical purity >99% and specific activity 2200 mCi/micromol. The synthesis time was 3.3-3.5h from the end of bombardment (EOB). 相似文献
5.
A. K. Mukhopadhyay S. Garg G. B. Nair S. Kar R. K. Ghosh S. Pajni A. Ghosh T. Shimada T. Takeda Y. Takeda 《Epidemiology and infection》1995,115(3):427-434
Sixty-nine strains of Vibrio cholerae O1 isolated at different times were analysed to investigate if there were any differences among the O1 strains isolated before, during and after the advent of the O139 serogroup. Of the 69 O1 strains examined, 68 belonged to the Ogawa serotype while one belonged to the Inaba serotype. With the exception of one strain all other strains of V. cholerae O1 belonged to the eltor biotype. A single O1 strain isolated before the emergence of the O139 serogroup could not be classified as either eltor or classical biotype because it was resistant to both classical and eltor specific bacteriophages. Marked variations in the susceptibility to antibiotics of V. cholerae O1 isolated during the different periods were observed. In addition, strains of V. cholerae isolated after the epidemic of serogroup O139 in Calcutta showed an expanding R-type with resistance to a variety of drugs as compared to the O1 strains isolated before the advent of the O139 serogroup. From this study, it is clear that there is a substantial mobility in genetic elements of V. cholerae O1 which necessitates a continuous monitoring to keep abreast of the changing traits of the etiologic agent of cholera. 相似文献
6.
Lorenzo Melani Richard Mills David Hassman Robert Lipetz Leslie Lipka Alexandre LeBeaut Ramachandran Suresh Pabak Mukhopadhyay Enrico Veltri 《European heart journal》2003,24(8):717-728
AIMS: To evaluate the efficacy and safety of ezetimibe 10 mg administered with pravastatin in patients with primary hypercholesterolemia. METHODS AND RESULTS: After dietary stabilization, 2-12 week screening/washout period, and 4-week, single-blind, placebo lead-in period, 538 patients with baseline LDL-C > or =3.8 to < or =6.5 mmol/l and TG < or =4.0 mmol/l were randomized to one of eight possible treatments administered daily for 12 weeks: ezetimibe 10mg; pravastatin 10, 20, or 40 mg; ezetimibe 10 mg plus pravastatin 10, 20, or 40 mg; or placebo. The primary efficacy endpoint was percent reduction in LDL-C from baseline to study endpoint for ezetimibe 10 mg plus pravastatin (pooled doses) compared to pravastatin alone (pooled doses) and ezetimibe alone. The combined use of ezetimibe and pravastatin resulted in significant incremental reductions in LDL-C and TG compared to pooled pravastatin alone (p<0.01). Coadministration therapy reduced LDL-C by 34-41%, TG by 21-23%, and increased HDL-C by 7.8-8.4%, depending on the dose of pravastatin. The combined regimen was well tolerated, with a safety profile similar to pravastatin alone and placebo. CONCLUSIONS: When coadministered with pravastatin, ezetimibe provided significant incremental reductions in LDL-C and TG and was well tolerated with a safety profile similar to pravastatin alone. 相似文献
7.
Mukhopadhyay S Mukhopadhyay S Banki K Mahajan S 《Archives of pathology & laboratory medicine》2004,128(12):1445-1447
We report on 2 patients who were initially suspected to have classic Hodgkin lymphoma because of lymphadenopathy and the presence of Reed-Sternberg-like cells. Both patients had an associated leukemoid reaction (using a threshold leukocyte count of 50 000/microL) and were eventually diagnosed with metastatic carcinoma. Disseminated carcinoma can mimic Hodgkin lymphoma clinically, radiologically, and histologically. Reed-Sternberg-like cells may be found in carcinomas, and they represent a particularly challenging diagnostic pitfall for the unwary. When these cells lead to a suspicion of Hodgkin lymphoma, the presence of a leukemoid reaction should prompt the pathologist to question the diagnosis. Misdiagnosis can be avoided by the use of cytokeratin whenever a leukemoid reaction is present in a suspected case of Hodgkin lymphoma. 相似文献
8.
Jain A Jain S Chowdhury V Mukhopadhyay S Aggarwal A Kar P 《The Journal of the Association of Physicians of India》1999,47(7):730-732
Pancreatic adenocarcinoma can present with a vast spectrum of rare manifestations. It usually occurs after the age of 50 years, the peak incidence being in sixth and seventh decades. We report a previously asymptomatic subject of pancreatic adenocarcinoma who presented for the first time with massive upper gastrointestinal hemorrhage. Endoscopy revealed ruptured esophageal varices which were secondary to tumour-induced thrombosis of the portal vein. Besides the uncommon mode of presentation, the patient was unusual because of his young age. Further, he was non-icteric at the time of presentation and remained so throughout the clinical course despite having a large lesion in the head of the pancreas. 相似文献
9.
Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore
essential for the maintenance of spermatogenesis. The expression and the localisation of ET (endothelin) and its receptors
in testicular tissue, in seminiferous tubules and in human testicular capillaries were studied. ET-1 mRNA was detected in
whole testicular tissue and in seminiferous tubules whereas isolated testicular capillaries were negative. Big ET-1 (Big endothelin
1) and ET peptides were localised in Leydig and Sertoli cells whereas interstitial and intramural capillaries (within the
lamina propria) remained unstained. ET was also found in mature spermatids. ET-A (endothelin receptor A) mRNA was detected
in seminiferous tubules and whole testicular tissue whereas testicular blood vessels were negative. ET-A immunostaining was
displayed in Leydig and Sertoli cells and in spermatids. ET-B (endothelin receptor B) mRNA was detected in whole testicular
tissue, seminiferous tubules and in testicular capillaries. ET-B peptide was prominent in Leydig cells, peritubular cells,
endothelial cells and pericytes of interstitial and intramural capillaries as well as in vascular endothelial and smooth muscle
cells. From these results we conclude that ET produced in Leydig and Sertoli cells can act in a paracrine manner via ET-B
on the human testicular microvasculature and the peritubular cells. The presence of both ET-A and ET-B in Leydig cells and
of ET-A in Sertoli cells leads to the assumption that ET could influence these cells as an autocrine factor.
Accepted: 9 October 1998 相似文献
10.
Scavenger receptors in innate immunity. 总被引:17,自引:0,他引:17
Leanne Peiser Subhankar Mukhopadhyay Siamon Gordon 《Current opinion in immunology》2002,14(1):123-128
Scavenger receptors (SR) are expressed by myeloid cells (macrophages and dendritic cells) and certain endothelial cells. They play an important role in uptake and clearance of effete components, such as modified host molecules and apoptotic cells. They bind and internalise micro-organisms and their products including Gram-positive bacteria (lipoteichoic acid), Gram-negative bacteria (lipopolysaccharide), intracellular bacteria and CpG DNA. SR can alter cell morphology and their expression is affected by various cytokines. SR are involved in lipid metabolism and bind modified low-density lipoproteins. 相似文献