全文获取类型
收费全文 | 75篇 |
免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 2篇 |
妇产科学 | 3篇 |
基础医学 | 18篇 |
口腔科学 | 1篇 |
临床医学 | 6篇 |
内科学 | 9篇 |
皮肤病学 | 1篇 |
神经病学 | 10篇 |
外科学 | 2篇 |
综合类 | 4篇 |
眼科学 | 6篇 |
药学 | 5篇 |
肿瘤学 | 4篇 |
出版年
2023年 | 3篇 |
2022年 | 5篇 |
2021年 | 10篇 |
2020年 | 3篇 |
2019年 | 2篇 |
2018年 | 5篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 1篇 |
2014年 | 4篇 |
2013年 | 6篇 |
2012年 | 4篇 |
2011年 | 5篇 |
2010年 | 3篇 |
2009年 | 6篇 |
2008年 | 2篇 |
2007年 | 3篇 |
2006年 | 2篇 |
2005年 | 1篇 |
2004年 | 1篇 |
2003年 | 1篇 |
2002年 | 4篇 |
2000年 | 1篇 |
排序方式: 共有78条查询结果,搜索用时 218 毫秒
1.
2.
Biswas Mainak Saba Luca Omerzu Tomaž Johri Amer M. Khanna Narendra N. Viskovic Klaudija Mavrogeni Sophie Laird John R. Pareek Gyan Miner Martin Balestrieri Antonella Sfikakis Petros P Protogerou Athanasios Misra Durga Prasanna Agarwal Vikas Kitas George D Kolluri Raghu Sharma Aditya Viswanathan Vijay Ruzsa Zoltan Nicolaides Andrew Suri Jasjit S. 《Journal of digital imaging》2021,34(3):581-604
Journal of Digital Imaging - Cardiovascular diseases (CVDs) are the top ten leading causes of death worldwide. Atherosclerosis disease in the arteries is the main cause of the CVD, leading to... 相似文献
3.
Mainak Mukhopadhyay Sayak Roy Mridul Bera Guruprasad Bhattacharya 《Current Cardiology Reviews》2020,16(4):341
Introduction Sleep-related problems like sleep apnea are increasing tremendously mostly owing to the disordered lifestyle the present generation is leading which is added like a topping on the base of obesity and metabolic syndrome. The burden on the society is huge taking into consideration the work-time loss and health-related financial issues arising out of these sleep disorders with obstructive sleep apnea (OSA) leading the way. Early diagnosis can prevent several complications of OSA. Cardiovascular diseases, including various arrhythmias, arising due to OSA, are described previously.Case Presentation Herein, an interesting case of OSA, whose pacemaker installation to rectify the long pause could be avoided by simple correction of his OSA using continuous positive airway pressure, is presented. This 49-year-old male patient was diagnosed with severe OSA by using polysomnography and all his significant sinus pauses (highest one with 7.8 sec) during holter ECG monitoring were found to be occurring at night and correcting his OSA with continuous positive airway pressure (CPAP) treatment reverted all those sinus pauses and the need for any further intervention with pacemaker was discarded.Discussion OSA is caused by either partial or complete obstruction of the upper airway, and there is the simultaneously attenuated upper airway dilator muscle tone while the patient is sleeping. The gold standard test designed for the assessment of OSA is polysomnography, as approved by the American Academy of Sleep Medicine and CPAP has been found to be universally beneficial in treating OSA related complications. Physiologically, the ACC/AHA guidelines recommend pacing only in patients with prolonged asymptomatic pauses occurring during wakefulness. This case report proved the above mentioned claim of CPAP treatment. 相似文献
4.
Mainak Mukhopadhyay Nandini Chatterjee Pranab Maity Kartik Patar 《Indian Journal of Critical Care Medicine》2014,18(2):110-112
Spontaneous rupture of the spleen with hemoperitoneum is a very rare, but serious manifestation of dengue fever (DF). We report a case of a young female who was presented with atraumatic abdominal pain, hypovolemic shock, anemia, ascites and hepatosplenomegaly with a recent history of a febrile illness. Subsequent investigations proved the presence of hemoperitoneum with spontaneous splenic rupture with seropositivity for DF. Early diagnosis and conservative management in this case resulted in a favorable outcome. 相似文献
5.
6.
Kausik Ganguly Tithi Dutta Arpan Saha Devroop Sarkar Asim Sil Kunal Ray Mainak Sengupta 《Annals of human genetics》2020,84(3):303-312
Oculocutaneous albinism (OCA) is a group of congenital autosomal recessive disorders with seven known subtypes (OCA1–OCA7) characterized by loss or absence of pigmentation in the skin, hair, and eyes. OCA1, caused by pathogenic variations in the tyrosinase (TYR) gene, has been documented to be the most prevalent subtype across the world including India. In the present study, we recruited 53 OCA-affected individuals from 45 unrelated families belonging to 20 different marriage groups/ethnicities of 15 different districts of West Bengal. We took a targeted sequencing-based approach to find the causal variations in the TYR gene. We report here identification of two novel potentially pathogenic variations [NM_000372.4:c.614C>T, NP_000363.1:p.(Pro205Leu), and NM_000372.4:c.1036+1=/G>T], one novel synonymous TYR variant [NM_000372.4:c.204=/A>G, NP_000363.1:p.(Gln68=)], two pathogenic variations documented for the first time in Indian OCA cases [NM_000372.4:c.1147G>A, NP_000363.1:p.(Asp383Asn), and NM_000372.4:c.585G>A, NP_000363.1:p.(Trp195*)], along with nine previously reported pathogenic variants in 36 out of 53 (∼68%) patients recruited. We report common haplotype backgrounds for the two most prevalent variations [NM_000372.4:c.124G>A, NM_000372.4:c.832C>T] in cases belonging to different marriage/ethnic groups, suggesting a possible founder effect. To our knowledge, this is the most comprehensive genetic study on OCA1 from India, firmly establishing OCA1 as the commonest form of albinism in this part of the world. 相似文献
7.
John W. Rumsey Mainak Das Maria Stancescu Marga Bott Cristina Fernandez-Valle James J. Hickman 《Biomaterials》2009,30(21):3567-3572
One of the most significant interactions between Schwann cells and neurons is myelin sheath formation. Myelination is a vertebrate adaptation that enables rapid conduction of action potentials without a commensurate increase in axon diameter. In vitro neuronal systems provide a unique modality to study both factors influencing myelination and diseases associated with myelination. Currently, no in vitro system for motoneuron myelination by Schwann cells has been demonstrated. This work details the myelination of motoneuron axons by Schwann cells, with complete Node of Ranvier formation, in a defined in vitro culture system. This defined system utilizes a novel serum-free medium in combination with the non-biological substrate, N-1[3 (trimethoxysilyl) propyl] diethylenetriamine (DETA). The myelinated segments and nodal proteins were visualized and quantified using confocal microscopy. This defined system provides a highly controlled, reproducible model for studying Schwann cell interactions with motoneurons as well as the myelination process and its effect on neuronal plasticity. Furthermore, an in vitro system that would allow studies of motoneuron myelination would be beneficial for understanding peripheral demyelinating neuropathies such as diabetes induced peripheral neuropathy and could lead to a better understanding of CNS demyelinating diseases like multiple sclerosis, as well as neuromuscular junction maturation and maintenance. 相似文献
8.
Abdominal cocoon: Report of a case 总被引:2,自引:0,他引:2
The abdominal cocoon is a rare cause of intestinal obstruction most often found in adolescent girls from tropical and subtropical
countries. It is characterized by a thick fibrotic sac covering the small bowel partially or completely, the etiology of which
is unknown. A correct diagnosis is not often made preoperatively; however, following simple surgical release of the entrapped
bowel, these patients usually do well. We report herein our experience of a case of abdominal cocoon with a brief review of
the medical literature on this unusual disease entity.
Received: May 26, 1999 / Accepted: May 30, 2000 相似文献
9.
Tao Xu Peter Molnar Cassie Gregory Mainak Das Thomas Boland James J. Hickman 《Biomaterials》2009,30(26):4377-4383
Rat embryonic hippocampal neurons were cultured in (1) 3D collagen hydrogels as ‘entrapped’ evenly distributed cells, (2) at the interface of two collagen layers (sandwich model), and (3) on the surface of collagen coated coverslips (2D model). In the ‘entrapment’ model the neuronal processes grew out of the plane of the cell body and extended into the collagen matrix, in contrast to the sandwich model where the cells and their processes rarely left the plane in which they were seeded. Hippocampal neurons ‘entrapped’ in the 3D collagen gel grew the same number, but shorter, processes and exhibited improved survival compared to neurons cultured in the 2D model. There was no difference in the electrophysiological properties of the neurons cultured in the 3D compared to the 2D model except in the resting membrane potential and in the duration of the after-hyperpolarization. Spontaneous postsynaptic currents were recorded in 14- and 21-day-old 3D cultures evidencing functional synapse formation. Our results indicate that the physiological characteristics of 3D neuronal cultures are similar to traditional 2D cultures. However, functional 3D networks of hippocampal neurons will be necessary for multi-level circuit formation, which could be essential for understanding the basis of physiological learning and memory. 相似文献
10.
Varghese K Das M Bhargava N Stancescu M Molnar P Kindy MS Hickman JJ 《Journal of neuroscience methods》2009,177(1):51-59
Although the majority of human illnesses occur during adulthood, most of the available in vitro disease models are based upon cells obtained from embryonic/fetal tissues because of the difficulties involved with culturing adult cells. Development of adult mouse neuronal cultures has a special significance because of the abundance of transgenic disease models that use this species. In this study a novel cell culture method has been developed that supports the long-term survival and physiological regeneration of adult mouse hippocampal cells in a serum-free defined environment. In this well-defined, controlled system, adult mouse hippocampal cells survived for up to 21 days in culture. The cultured cells exhibited typical hippocampal neuronal morphology and electrophysiological properties after recovery from the trauma of dissociation, and stained positive for the expected neuronal markers. This system has great potential as an investigative tool for in vitro studies of adult diseases, the aging brain or transgenic models of age-associated disorders. 相似文献