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1.
Patients with mood depression have been found to have a higher prevalence of seborrheic dermatitis (SD), possibly related to their tendency to live indoors. The prevalence of outpatients with SD has now been found to be directly related to the number of gloomy days in the area. Since UV light might not be the only reason for the well-known improvement in SD in summer, an explanation possibly related to melatonin is envisaged. 相似文献
2.
Vera Adema Laura Palomo Andrea Toma Olivier Kosmider Francisco Fuster-Tormo Rocío Benito Rocío Salgado Esperanza Such María José Larrayoz Blanca Xicoy Jesus Maria Hernandez-Sanchez Paolo Maietta Alexander Neef Michaela Fontenay Mariam Ibañez Maria Diez-Campelo Sara Alvarez Jaroslaw P. Maciejewski Pierre Fenaux Francesc Sole 《British journal of haematology》2020,189(4):e133-e137
3.
Hemorrhoidectomy remains the most definitive procedure to treat symptomatic grades III and IV hemorrhoids. However, over the years, several modifications have been made to the original operation to improve the outcomes. A total of 693 consecutive patients with grade III and IV hemorrhoids underwent Ferguson hemorrhoidectomy. Our results serve as a standard for comparison conventional hemorrhoidectomy (Ferguson's technique) with recent methods such as stapled hemorrhoidopexy and LigaSure hemorrhoidectomy. We have obtained a very low rate of post-operative pain after Ferguson hemorrhoidectomy (VAS pain score was 2.47 ± 1.1 after a day, 1.34 ± 0.7 after 7 days and 0.51 ± 0.1 after 2 weeks) as to for stapler and LigaSure procedure in the literature. Moreover, long-term results demonstrate high levels of patient satisfaction (the satisfaction was good in 624 patients after 2 weeks and in 658 patients after 1 year) with a low recurrence rates (7 patients had recurrence after 1 year and 21 patients after 2 years). We believe that Ferguson-closed hemorrhoidectomy could still be, at the moment, the gold standard to which other techniques are compared. 相似文献
4.
Plinio Cirillo Salvatore De Rosa Vito Di Palma Roberta De Rosa Paola Maietta Federico Piscione Massimo Chiariello 《Heart and vessels》2009,24(4):313-316
Drug-eluting stents (DES) have become routine therapy in clinical practice because restenosis is significantly reduced in
patients treated with these devices. New generations of DES bearing newer antiproliferative drugs have been developed. Sirolimus
was the first antiproliferative drug eluted by a DES (SES) while Zotarolimus represents a sirolimus-derived, newer antiproliferative
drug borne by a different kind of DES (ZES). This report describes two cases of different vascular response to concurrent
side by side implantation of SES and ZES in the same vessel and highlights significant early restenosis of ZES as compared
with SES. 相似文献
5.
Igor Diemberger Francesco Pegreffi Andrea Mazzotti Elia Foschi Cristian Martignani Guido Belli Mauro Biffi Matteo Ziacchi Angelo Branzi Francesco Grigioni Pasqualino Maietta Latessa Giuseppe Porcellini Claudio Tentoni Giuseppe Boriani 《International journal of cardiology》2013
Background
Subcutaneous almost substituted subpectoral approach of implantable cardioverter-defibrillator (ICD) implantation as a less invasive surgical technique. However, the impact of this change in placement site on procedure-related shoulder impairment is poorly understood.Methods
Candidates for ICD implantation were prospectively evaluated at baseline, 2-weeks and 3-months after the procedure. Assessment of shoulder function included: Constant Score, Numeric Rating Scale (NRS) for pain and the Disability of the Arm, Shoulder and Hand (DASH) scoring method. The Short Form-36 (SF-36) questionnaire was adopted for quality of life.Results
Fifty consecutive patients were enrolled (21 single-chamber, 5 dual-chamber and 24 biventricular ICD). Significant changes in the short term were observed: physical component summary (regarding SF-36) decreased from 44.5 ± 9.1 to 41.8 ± 11.4 (p = 0.016), patients with NRS > 1 increased from 14% to 44% (p < 0.001), DASH score increased from 1.29 [interquartile range 0.00–10.34] to 30.60 [interquartile range 12.93–46.34] (p < 0.001). Notably, only the shoulder ipsilateral to implantation site presented a decrease in Constant Score (76.00 [interquartile range 61.37–86.87] vs. 95.75 [interquartile range 91.37–98.00]; p < 0.001). After three months most of the parameters seemed to have recovered, except for range of motion. Procedure-related increase in pain (i.e. NRS increase ≥ 1 point) was the most important independent predictor of shoulder impairment, in terms of Constant Score modification (r = 0.570; p < 0.001).Conclusions
ICD implantation is frequently associated with ipsilateral shoulder impairment which tends to recover within 3-months. These data positively compare with the subpectoral approach and should be considered for future research regarding impact of ICD implant on physical well-being and quality of life. 相似文献6.
Lauretta Maggi Giovanna Bruni Mariarosa Maietta Andrea Canobbio Andrea Cardini Ubaldo Conte 《International journal of pharmaceutics》2013
Nateglinide is a non-sulphonylurea insulinotropic oral antidiabetic agent. The main problem in formulating an oral dosage form is its low solubility in aqueous media. This problem is particularly critical for an anti-diabetic drug because it should be administered just before the meals and be quickly bioavailable to cover the post-prandial glycemic peak. In this work, some technological approaches have been studied to improve the dissolution rate of nateglinide. Furthermore, two different polymorphs of nateglinide (H and B) have been tested to evaluate the influence of the crystal habitus on the dissolution behavior of the drug. The results have clearly demonstrated that wettability plays a key role in the dissolution behavior of nateglinide. As a matter of fact the physical dispersion of the drug with colloidal silica or hydrophilic swellable polymers strongly enhances the dissolution rate of nateglinide. The two polymorphs tested did not show significant differences in terms of dissolution behavior. 相似文献
7.
Marco Milone Matteo Nicola Dario Di Minno Maddalena Leongito Paola Maietta Paolo Bianco Caterina Taffuri Dario Gaudioso Roberta Lupoli Silvia Savastano Francesco Milone Mario Musella 《World journal of gastroenterology : WJG》2013,19(39):6590-6597
AIM:To investigate the weight loss and glycemic control status[blood glucose,hemoglobin A1c(HbA1c)and hypoglycaemic treatment].METHODS:The primary risk factor for type 2 diabetes is obesity,and 90%of all patients with type 2 diabetes are overweight or obese.Although a remarkable effect of bariatric surgery is the profound and durable resolution of type 2 diabetes clinical manifestations,little is known about the difference among various weight loss surgical procedures on diabetes remission.Data from patients referred during a 3-year period(from January2009 to December 2011)to the University of Naples"FedericoⅡ"diagnosed with obesity and diabetes were retrieved from a prospective database.The patients were split into two groups according to the surgical intervention performed[sleeve gastrectomy(SG)and mini-gastric bypass(MGB)].Weight loss and glycemic control status(blood glucose,HbA1c and hypoglycaemic treatment)were evaluated.RESULTS:A total of 53 subjects who underwent sleeve gastrectomy or mini-gastric bypass for obesity and diabetes were screened for the inclusion in this study.Of these,4 subjects were excluded because of surgical complications,7 subjects were omitted because young surgeons conducted the operations and 11 subjects were removed because of the lack of follow-up.Thirtyone obese patients were recruited for this study.A total of 15 subjects underwent SG(48.4%),and 16underwent MGB(51.6%).After adjusting for various clinical and demographic characteristics in a multivariate logistic regression analysis,high hemoglobin A1c was determined to be a negative predictor of diabetes remission at 12 mo(OR=0.366,95%CI:0.152-0.884).Using the same regression model,MGB showed a clear trend toward higher diabetes remission rates relative to SG(OR=3.780,95%CI:0.961-14.872).CONCLUSION:Although our results are encouraging regarding the effectiveness of mini-gastric bypass on diabetes remission,further studies are needed to provide definitive conclusions in selecting the ideal procedure for diabetes remission. 相似文献
8.
F. Mastrandrea G. Serio A. Minardi G. Coradduzza N. Rossi G. Scarcia G. Maietta A. Iacobelli C. Lamanna A. Tursi 《Allergy》1997,52(11):1115-1119
We investigated by ELISA the IgE response to whole extract of the house-dust mite Dermatophagoides pteronyssinus (Dp) and to the native major allergens, Der p 1 and Der p 2, in sera from 18 adult patients (group A) with Dp-allergic asthma before ( t 0 ) and 1, 2, 3, and 4 ( t 1 – t 4 ) years after subcutaneous specific immunotherapy (SIT). A qualitative reduction ( P =0.05) of the IgE responses to Dp and Der p 2 was observed from t 1 to t 4 , but a highly statistical significant decrease appeared at t 3 , ( P < 0.01). With regard to Der p 1 IgE values, the immunotherapy induced a significant decrease ( P < 0.01) at t 3 , but not before. In group A, the IgE responses to Der p 1 and Der p 2 were not correlated at t 0 ( r s =0.31; P = 0.2l) but were correlated at t3 ( r s = 0.78; P=0.001). We also examined sera from 14 adult patients (group B, same SIT schedule as group A) who were without respiratory symptoms at the end of the third year (t3 ) of Dp SIT. At this time ( t 3 ), there were no significant differences in Der p 1 and Der p 2 IgE levels between group A and group B. 相似文献
9.
Marco Milone Matteo Nicola Dario Di Minno Giuseppe Bifulco Paola Maietta Loredana Maria Sosa Fernandez Mario Musella Vittorio Iaccarino Claudio Buccelli Carmine Nappi Francesco Milone 《Journal of gastrointestinal surgery》2013,17(9):1673-1682
Background
To the best of our knowledge, this is the first study to evaluate the predictive value of free air (on a plain radiograph) for bowel perforation in a large prospective cohort of surgical patients.Methods
All consecutive patients undergoing abdominal surgery between January 2011 and June 2012 were screened for this study. We performed an upright chest radiograph on the second and third postoperative day. Thereafter, additional radiographic evaluations were performed every 2 days until the disappearance of abdominal free air.Results
Of the 648 subjects enrolled in our study, free abdominal air was found in 65 subjects on the first radiographic evaluation (2 days after surgery), 51 on the second (3 days after surgery), three on the third (5 days after surgery), and none on the fourth (7 days after surgery). The presence of free abdominal air was associated with an increased risk of gastrointestinal perforation. The presence of free air was associated with a hazard ratio (HR) of 21.54 (95% CI 9.66–48.01, p<0.001) and a HR of 23.87 (95% CI 10.68–53.34, p<0.001) at 2 and 3 days after surgery, respectively. Sensitivity, specificity, positive predictive value, and negative predictive value were 70, 93, 33, and 98%, respectively, at 2 days after surgery, and similar results were confirmed at 3 days after surgery.Conclusion
We believe that the presence of free air at 3 days after surgery should not be considered a common finding. Here, we demonstrate that the detection of free air has a remarkable predictive value for gastrointestinal perforation, which has been overestimated in previous experience. 相似文献10.
Effects of whole-body cryotherapy on the innate and adaptive immune response in cyclists and runners
Nasi Milena Bianchini Elena Lo Tartaro Domenico De Biasi Sara Mattioli Marco Paolini Annamaria Gibellini Lara Pinti Marcello De Gaetano Anna D’Alisera Roberta Roli Laura Chester Johanna Mattioli Anna Vittoria Polverari Tomassina Maietta Pasqualino Tripi Ferdinando Stefani Omar Guerra Emanuele Savino Gustavo Trenti Tommaso Cossarizza Andrea 《Immunologic research》2020,68(6):422-435
Immunologic Research - The study aimed to identify the effects of whole-body cryotherapy (WBC) on immunological, hormonal, and metabolic responses of non-professional male athletes. Ten cyclists... 相似文献