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1.
TOSHIYASU SAKANE MOTOHIRO AKIZUKI YOKO TAKI SHINJI YAMASHITA HITOSHI SEZAKI TANEKAZU NADAI 《The Journal of pharmacy and pharmacology》1995,47(5):379-381
To clarify the relationship between the direct transport from the rat nasal cavity to the cerebrospinal fluid (CSF) and the molecular weight of the drug, the transport of fluorescein isothiocyanate-labelled dextran (FD) with various molecular weights was investigated. FDs (average molecular weights 4400 (FD4); 9400 (FD10); 18 900 (FD20); 40 500 Da (FD40)) were administered nasally or intravenously to rats, and the concentrations in the plasma and the CSF were measured and compared. None of the FDs were detected in the CSF after intravenous administration. However, FD4, FD10 and FD20 were observed to appear in the CSF after nasal administration, whereas the concentration in the plasma was much lower than that after intravenous administration. FD40 was not detected even after nasal administration. In addition, the concentration of these FDs in the CSF decreased with the increase in the molecular weight of FDs. These findings show that drugs with a molecular weight up to at least 20 000 Da can be directly transported from the nasal cavity to the CSF and that the transport of FDs to the CSF is dependent on their molecular weights. 相似文献
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TSUTOMU TAKEYA YOSHITERU OHNO HIDEKI MATSUBARA KOHICHI YASUDA SUSUMU WATANABE RISHUN SHINZATO YOSHIHARU TANAKA SATOKO NODA 《Clinical otolaryngology》1979,4(3):197-205
In order to investigate the physiological changes produced by the treatment of acrophobic patients body movement and Microvibration were measured before and after treatment. Eighteen acrophobic patients were assigned at random to 1 of the 2 groups: a treatment group (n= 8) and a non-treatment group (n= 10). The control group consisted of 16 healthy volunteers. Body movement area while viewing a slide of a high place or imagining a high place in the treatment group decreased significantly after treatment. Body movement of the control group showed almost no changes, and that of the non-treatment group was situated between the above-mentioned 2 groups. Simple body movements of the acrophobic patients without any stimulation of height were bigger than those of the control subjects. MV pattern of the treatment group had a tendency to improve under psychotherapy. Acrophobic patients had more abnormal MV patterns than the normal subjects. 相似文献
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TARO KONO MD PHD BRIAN M. KINNEY SM MD WILLIAM FREDERICK GROFF DO HENRY H. CHAN MD FRCP ALI RIZA ERCOCEN MD MOTOHIRO NOZAKI MD PHD 《Dermatologic surgery》2008,34(S1):S25-S30
BACKGROUND At present, various hyaluronic acids are being used to rejuvenate facial skin. There is no comparative study of single cross-linked hyaluronic acid (SCHA) versus double cross-linked hyaluronic acid (DCHA). The objective of our study is to compare the effectiveness and complications of SCHA versus DCHA in the treatment of glabellar lines.
METHODS Ten female patients were enrolled in this randomized, evaluator-blind study. One side (left vs. right) of each patient's glabellar lines was treated with SCHA and the other side was treated with DCHA. Two independent blinded observers reviewed the clinical photographs at 3, 6, 9, and 12 months after the treatment and assessed for degree of improvement as well as complications.
RESULTS The two products were equally effective in producing an optimal cosmetic result, although at 6, 9, and 12 months posttreatment, a higher proportion of patients showed over 50% improvement with DCHA than with SCHA. At 12 months posttreatment, DCHA was considered superior in 70% of patients, whereas SCHA was superior in 10% of patients.
CONCLUSIONS Both SCHA and DCHA are equally effective in producing an optimal cosmetic result. DCHA provides a more durable esthetic improvement when compared to SCHA in the treatment of glabellar lines. 相似文献
METHODS Ten female patients were enrolled in this randomized, evaluator-blind study. One side (left vs. right) of each patient's glabellar lines was treated with SCHA and the other side was treated with DCHA. Two independent blinded observers reviewed the clinical photographs at 3, 6, 9, and 12 months after the treatment and assessed for degree of improvement as well as complications.
RESULTS The two products were equally effective in producing an optimal cosmetic result, although at 6, 9, and 12 months posttreatment, a higher proportion of patients showed over 50% improvement with DCHA than with SCHA. At 12 months posttreatment, DCHA was considered superior in 70% of patients, whereas SCHA was superior in 10% of patients.
CONCLUSIONS Both SCHA and DCHA are equally effective in producing an optimal cosmetic result. DCHA provides a more durable esthetic improvement when compared to SCHA in the treatment of glabellar lines. 相似文献
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M. HIDE T. HONDO S. YONEHARA Y. MOTOHIRO S. OKANO 《The British journal of dermatology》1997,136(1):121-123
Infections caused by Mycobacterium avium—intracellulare complex are generally manifested as pulmonary disease, osteomyelitis or lymphadenitis, and cutaneous infection is rare. We describe a case of M. intracellulare infection of the skin in a 79-year-old man without apparent immunologically disabling disease or therapy. He had cutaneous infection of the right hand over 10 years, developing a fistula and, finally, an ulcer and abscess, 2 months before his death from heart failure. Mycobacteriu intacellulare was identified by both microbiological characteristics and DNA-DNA hybridization. 相似文献
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AKIHIKO NOGAMI MOTOHIRO NAKAO SHOICHI KUBOTA AIKO SUGIYASU HIROSHI DOI KEN YOKOYAMA KAZUHIKO YUMOTO TOSHIYUKI TAMAKI KEN-ICHI KATO NORIYO HOSOKAWA† HIROSHI SAGAI† HIROYUKI NAKAMURA‡ JUN-ICHI NITTA‡ YASUTERU YAMAUCHI§ KAZUTAKA AONUMA§ 《Pacing and clinical electrophysiology : PACE》2003,26(1P2):332-337
NOGAMI, A., et al. : Enhancement of J–ST-Segment Elevation by the Glucose and Insulin Test in Brugada Syndrome. The effects of glucose and insulin on J–ST-segment elevation were evaluated in seven men (mean age 45 ± 10 years) with Brugada syndrome. Six patients had been reanimated from VF and one patient had experienced syncope. The effects of intravenous (1) pilsicainide 50 mg, (2) glucose 50 g, and (3) glucose 50 g plus regular insulin 10 IU on the precordial ECG leads were examined. Pilsicainide significantly enhanced J-ST elevation in all patients and induced VF in 1 patient. A significant accentuation of the abnormal J-ST configuration was observed in all patients at a mean of 51 ± 40 minutes after glucose and insulin infusion. Changes in blood glucose and serum potassium concentration were 111 ± 158 mg/dL and −0.30 ± 0.48 mEq/L , respectively. These changes were not directly related to the ECG changes. Glucose infusion without insulin caused a subtle increase in J-ST elevation. In conclusion, the administration of glucose and insulin safely unmasked or accentuation the J–ST-segment elevation in Brugada syndrome. Blood glucose and insulin concentrations may be factors modulating the circadian or day-to-day ECG variations in this syndrome. (PACE 2003; 26[Pt. II]:332–337) 相似文献
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GEN KAWA MOTOHIRO TATSUMI YOSHIHITO HIURA KOEI MUGURUMA HIDEFUMI KINOSHITA TADASHI MATSUDA 《International journal of urology》2006,13(9):1171-1174
AIM: Reconstructive laparoscopic procedures have been recognized as a less invasive treatment than conventional open procedures. However, although the laparoscopic pyeloplasty has also been accepted as useful, few findings have been reported relevant to the retroperitoneal approach. To elucidate its effectiveness and safety, laparoscopic surgery via the retroperitoneal approach was examined in our institution. Furthermore, the importance of laparoscopic observation for ureteropelvic junction and urine passage ureteropelvic junction without indwelling ureteral stent. METHODS: Between July 1998 and December 2004, 13 men and 15 women underwent laparoscopic retroperitoneal surgery for ureteropelvic junction obstruction. The mean patient age was 33.6 years (range: 13-70 years). Methods of repair were determined by intraoperative findings for the relationship between the ureteropelvic junction and surrounding vessels. An indwelling ureteral stent was removed before initiating laparoscopic operation to observe the relationship between ureteropelvic junction and aberrant vessels more precisely. RESULTS: An aberrant renal vessel was found in 13 patients (46%). Dismembered pyeloplasty was carried out in 21 patients, Y-V plasty in five patients and Hellstrom technique in two patients. Ureteral transposition was not required in dismembered pyeloplasty cases. All patients achieved retroperitoneoscopic pyeloplasty without open conversion. The mean operative time was 272 min (range: 155-490 min). The mean estimated blood loss was 44 mL (range: 10-200 mL). No major complications were observed during the intraoperative period, but urinary tract infection occurred in two patients in the postoperative period. In all patients except one, obstruction was improved or resolved. CONCLUSIONS: Laparoscopic retroperitoneal surgery is not only able to repair ureteropelvic junction obstruction, but can also be done safety and less invasively. We believe that laparoscopic observation without indwelling stent will contribute to a more appropriate choice of pyeloplasty. 相似文献
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OHTA MITSUO; HARA NOBUYUKI; ICHINOSE YUKITO; MOTOHIRO AKIRA; TAKEO SADANORI; MIYAKE JUN 《Japanese journal of clinical oncology》1986,16(3):289-296
To assess the role of surgical resection in the management ofsmall cell carcinoma of the lung, experience with 118 patientswho were treated between 1973 and 1985 was reviewed. Twenty-fivepatients underwent surgical resection followed by combinationchemotherapy in all except one. The remaining 93 pa tients weretreated by combined chemotherapy and radiation therapy. The 5-year survival rate for patients with stage I disease undergoingsurgical resection was 50.8%. For all 25 patients operated on,the 5-year survival rate was 30.7%. In the patients not operated on, only those with complete responsehad long-term survival, for whom the 5-year survival rate was11.9% We consider that surgical resection is definitely indicatedin patients with stage I disease. If the response to initialchemotherapy is very good, patients with stage 11 or T3N0M0disease also probably should receive resection. Patients withN2 disease are not candidates for resection, unless distantmetastases are controlled completely by intensive chemotherapy. 相似文献
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RYOTA HASHIMOTO md phd SATOKO HATTORI p hd SACHIE CHIBA ms c YUKI YAGASAKI ms c TAKEYA OKADA p hd EMI KUMAMARU p hd TAKEYUKI MORI md KIYOTAKA NEMOTO md HISASHI TANII md phd HIROAKI HORI md HIROKO NOGUCHI ma TADAHIRO NUMAKAWA p hd TAKASHI OHNISHI md phd HIROSHI KUNUGI md phd 《Psychiatry and clinical neurosciences》2006,60(S1):S4-S10
Abstract It is well known that genetic factors contribute to the susceptibility for schizophrenia. Recent advances in the molecular genetics of schizophrenia strongly suggest several susceptibility genes (e.g. dysbindin, neuregulin-1, DISC1, COMT, G72, RGS4 and Akt1). We discuss the evidence and biology of these genes. As glutamate transmission is especially implicated in these genes, neurobiological basis of schizophrenia might be elucidated by investigation of functional interactions between susceptibility genes for schizophrenia and the glutamatergic system. 相似文献
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TARO KONO MD HENRY H. CHAN MD FRCP WILLIAM FREDERICK GROFF DO HIROYUKI SAKURAI MD MASAKI TAKEUCHI MD TAKASHI YAMAKI MD KAZUTAKA SOEJIMA MD MOTOHIRO NOZAKI MD 《Dermatologic surgery》2007,33(8):945-950
BACKGROUND AND OBJECTIVE: The 595-nm long-pulsed dye laser (LPDL) has been used for the treatment of vascular lesions, and although it is well absorbed by blood, it is also well absorbed by melanin. To utilize this device for the treatment of facial lentigines, we attached a glass window to the tip of the laser's handpiece, allowing compression of the skin during treatment. This prospective study aims to evaluate the efficacy and complications of using a LPDL delivered with compression for the treatment of facial lentigines in Asian persons. MATERIALS AND METHODS: Fifty-four Asian patients with facial lentigines were enrolled in this study. The laser settings included fluences between 9 and 13 J/cm(2) and a constant pulse duration of 1.5 ms. Cryogen spray cooling was not used. RESULTS: Thirty-eight patients showed excellent results, 14 patients showed good results, and 2 patients showed fair results. Hyperpigmentation was seen in 1 patient. CONCLUSION: LPDL delivered with the compression method is effective in the treatment of facial lentigines in Asian patients, and the side effect profile is minimal. The compression technique allows the traditional "vascular" LPDL to be used for treating a variety of pigmented lesions. 相似文献