The Effect of Aspirin on Recurrent Fetal Loss in Experimental Antiphospholipid Syndrome

PURPOSE: To evaluate the effect of aspirin treatment upon fetal loss in mice with experimental antiphospholipid syndrome (APLS). MATERIALS AND METHODS: Experimental APLS was induced in pregnant mice by passive transfer of mouse monoclonal anticardiolipin antibody. The mice were treated with high (100μg/d) or low (10μg/d) does of aspirin, using vitaminC(100μg/d or 10μg/d)as a control. The mice were assessed for the presence of lupus anticoagulants (prolonged aPTT), thrombocytopenia, degree of fetal resorption rate and mean embryo and placental weights. RESULTS: The mice with APLS had a higher fetal resorption rate(45.7± 12.2% vs 2.5 ± 0.4%, P<0.001), reduced placenta mean weight(104 ± 8 mgvs 169 ±7mg, P<0.001), prolonged aPTT (94± 14sec vs 39±4sec, P<0.001), and reduced mean platelet count(597± 186 ± 10³/mm³vs 847±51 ± 10³/mm³,P<0.001). The groupof mice with APLS, who were treated with low-dose aspirin, had a lower resorption rate (11.1 ±9.3% vs 45.7±12.2%, P<0.001), a higher placenta mean weight (178 ± 8 mg vs 104 ± 8 mg, P<0.001), a higher mean embryo weight (1042 ± 134 mg vs 721±91 mg, P<0.001), and a lower aPTT (58±15 sec vs 94±14 sec, P, <0.001). Micewho were treated with high-dose aspirin also had a lower resorption rate, although not as much as in the low-dose aspirin group (34.2 ± 12.7% vs 45.7 ± 12.2%, P<0.001). CONCLUSION: Aspirin, especially in low dose, has a protective effect against obstetrical complications associated with experimental APLS.     

Scientifically Based Rationale and Protocol for Use of Modern Indirect Resin Inlays and Onlays

The desire to place esthetically pleasing, conservative, functionally stable, posterior restorative materials has steadily increased over the past 20 years. The creation of successful dentin bonding adhesives and appropriate resin luting cements has paved the way for the development of a myriad of indirect resin-based restorative materials. These materials have been specifically designed to overcome the negative attributes of their porcelain counterparts, and to simplify fabrication, insertion, and post-delivery adjustments. Possibly like no other product before, these restorative materials have met with instant clinical acceptance by many practitioners, and concern exists that these materials have not been sufficiently studied to warrant such widespread acceptance. This article presents an overview of the history and development of resin-based, esthetic, indirect systems, and offers the clinician a review of the literature supporting their role in posterior restorative dentistry. Additionally, a scientifically based protocol for preparation, impressing, provisionalization, and subsequent cementation and adjustment of indirect laboratory-processed resin inlays and onlays is presented.
CLINICAL SIGNIFICANCE
This article reviews the history of indirect laboratory-processed resin restorations, reviews available literature supporting their use, and presents a scientifically based protocol for their placement and use as a viable alternative for conservative reconstruction of posterior teeth.