首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   2619330篇
  免费   191426篇
  国内免费   7585篇
耳鼻咽喉   34837篇
儿科学   86396篇
妇产科学   72508篇
基础医学   369301篇
口腔科学   71299篇
临床医学   237946篇
内科学   520804篇
皮肤病学   63440篇
神经病学   217437篇
特种医学   101654篇
外国民族医学   737篇
外科学   391437篇
综合类   50510篇
现状与发展   5篇
一般理论   992篇
预防医学   198422篇
眼科学   57461篇
药学   190663篇
  8篇
中国医学   5400篇
肿瘤学   147084篇
  2021年   20324篇
  2019年   21043篇
  2018年   30187篇
  2017年   23359篇
  2016年   27182篇
  2015年   30257篇
  2014年   41335篇
  2013年   62122篇
  2012年   82345篇
  2011年   86977篇
  2010年   52298篇
  2009年   49954篇
  2008年   81439篇
  2007年   86421篇
  2006年   87905篇
  2005年   83990篇
  2004年   80970篇
  2003年   78325篇
  2002年   75522篇
  2001年   129490篇
  2000年   132788篇
  1999年   111335篇
  1998年   31616篇
  1997年   28226篇
  1996年   28457篇
  1995年   27583篇
  1994年   25262篇
  1993年   23624篇
  1992年   85329篇
  1991年   81694篇
  1990年   78927篇
  1989年   76249篇
  1988年   69611篇
  1987年   68142篇
  1986年   63683篇
  1985年   60698篇
  1984年   45177篇
  1983年   38130篇
  1982年   22636篇
  1981年   20145篇
  1979年   39113篇
  1978年   27559篇
  1977年   23393篇
  1976年   21649篇
  1975年   22939篇
  1974年   26896篇
  1973年   25497篇
  1972年   23815篇
  1971年   22021篇
  1970年   20251篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Quality of Life Research - The COVID-19 pandemic might add to the stressors experienced by people living with rheumatic diseases. This study aimed to examine rheumatic patients’ functional...  相似文献   
2.
Molnár  B.  Aroca  S.  Dobos  A.  Orbán  K.  Szabó  J.  Windisch  P.  Stähli  A.  Sculean  A. 《Clinical oral investigations》2022,26(12):7135-7142
Clinical Oral Investigations - To evaluate t he long-term outcomes following treatment of RT 1 multiple adjacent gingival recessions (MAGR) using the modified coronally advanced tunnel (MCAT) with...  相似文献   
3.
Die Anaesthesiologie - Phantomschmerzen haben eine hohe Prävalenz nach Majoramputationen und sind mit einer zusätzlichen Einschränkung der Lebensqualität verbunden....  相似文献   
4.

Interstitial lung disease (ILD) represents a significant cause of morbidity and mortality in systemic sclerosis (SSc). The purpose of this study was to examine recirculating lymphocytes from SSc patients for potential biomarkers of interstitial lung disease (ILD). Peripheral blood mononuclear cells (PBMCs) were isolated from patients with SSc and healthy controls enrolled in the Vanderbilt University Myositis and Scleroderma Treatment Initiative Center cohort between 9/2017–6/2019. Clinical phenotyping was performed by chart abstraction. Immunophenotyping was performed using both mass cytometry and fluorescence cytometry combined with t-distributed stochastic neighbor embedding analysis and traditional biaxial gating. This study included 34 patients with SSc-ILD, 14 patients without SSc-ILD, and 25 healthy controls. CD21lo/neg cells are significantly increased in SSc-ILD but not in SSc without ILD (15.4 ± 13.3% vs. 5.8 ± 0.9%, p = 0.002) or healthy controls (5.0 ± 0.5%, p < 0.0001). While CD21lo/neg B cells can be identified from a single biaxial gate, tSNE analysis reveals that the biaxial gate is comprised of multiple distinct subsets, all of which are increased in SSc-ILD. CD21lo/neg cells in both healthy controls and SSc-ILD are predominantly tBET positive and do not have intracellular CD21. Immunohistochemistry staining demonstrated that CD21lo/neg B cells diffusely infiltrate the lung parenchyma of an SSc-ILD patient. Additional work is needed to validate this biomarker in larger cohorts and longitudinal studies and to understand the role of these cells in SSc-ILD.

  相似文献   
5.
6.
7.
Intratumor heterogeneity is a main cause of the dismal prognosis of glioblastoma (GBM). Yet, there remains a lack of a uniform assessment of the degree of heterogeneity. With a multiscale approach, we addressed the hypothesis that intratumor heterogeneity exists on different levels comprising traditional regional analyses, but also innovative methods including computer-assisted analysis of tumor morphology combined with epigenomic data. With this aim, 157 biopsies of 37 patients with therapy-naive IDH-wildtype GBM were analyzed regarding the intratumor variance of protein expression of glial marker GFAP, microglia marker Iba1 and proliferation marker Mib1. Hematoxylin and eosin stained slides were evaluated for tumor vascularization. For the estimation of pixel intensity and nuclear profiling, automated analysis was used. Additionally, DNA methylation profiling was conducted separately for the single biopsies. Scoring systems were established to integrate several parameters into one score for the four examined modalities of heterogeneity (regional, cellular, pixel-level and epigenomic). As a result, we could show that heterogeneity was detected in all four modalities. Furthermore, for the regional, cellular and epigenomic level, we confirmed the results of earlier studies stating that a higher degree of heterogeneity is associated with poorer overall survival. To integrate all modalities into one score, we designed a predictor of longer survival, which showed a highly significant separation regarding the OS. In conclusion, multiscale intratumor heterogeneity exists in glioblastoma and its degree has an impact on overall survival. In future studies, the implementation of a broadly feasible heterogeneity index should be considered.  相似文献   
8.
9.
10.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号