全文获取类型
收费全文 | 430篇 |
免费 | 43篇 |
专业分类
儿科学 | 10篇 |
妇产科学 | 11篇 |
基础医学 | 63篇 |
口腔科学 | 17篇 |
临床医学 | 35篇 |
内科学 | 141篇 |
皮肤病学 | 12篇 |
神经病学 | 39篇 |
特种医学 | 11篇 |
外科学 | 47篇 |
综合类 | 3篇 |
预防医学 | 32篇 |
眼科学 | 4篇 |
药学 | 32篇 |
肿瘤学 | 16篇 |
出版年
2021年 | 5篇 |
2020年 | 9篇 |
2019年 | 11篇 |
2018年 | 8篇 |
2017年 | 6篇 |
2016年 | 10篇 |
2015年 | 5篇 |
2014年 | 9篇 |
2013年 | 10篇 |
2012年 | 16篇 |
2011年 | 24篇 |
2010年 | 14篇 |
2009年 | 8篇 |
2008年 | 12篇 |
2007年 | 27篇 |
2006年 | 12篇 |
2005年 | 20篇 |
2004年 | 27篇 |
2003年 | 21篇 |
2002年 | 19篇 |
2001年 | 15篇 |
2000年 | 14篇 |
1999年 | 15篇 |
1998年 | 3篇 |
1997年 | 9篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 5篇 |
1993年 | 7篇 |
1992年 | 3篇 |
1991年 | 10篇 |
1990年 | 7篇 |
1989年 | 13篇 |
1988年 | 8篇 |
1987年 | 11篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1974年 | 5篇 |
1973年 | 3篇 |
1972年 | 4篇 |
1971年 | 4篇 |
1970年 | 6篇 |
排序方式: 共有473条查询结果,搜索用时 11 毫秒
1.
2.
A family with five persons affected with fibrodysplasia ossificans progressiva (myositis ossificans progressiva) in three generations is described. This is the first well documented three generation family with this condition and provides further evidence for autosomal dominant inheritance. A wide range of phenotypic severity is apparent, from disabling ectopic bone formation and premature death to an asymptomatic adult with characteristic big toe malformations. 相似文献
3.
D Eccles P Lunt Y Wallis M Griffiths B Sandhu S McKay D Morton J Shea-Simonds F MacDonald 《Archives of disease in childhood》1997,77(5):431-435
Familial adenomatous polyposis (FAP) is a dominantly inherited predisposition to the development of many hundreds to thousands of adenomatous polyps of the colon. The mean age of onset is around 15 years, symptoms may arise in the third decade, and the median age for the development of colonic cancer is 35-40 years. Prophylactic colectomy reduces the risk of death from colorectal cancer to such an extent that late sequelae such as upper gastrointestinal tumours have become the main cause of mortality in appropriately managed patients. The age at which colonic surveillance begins reflects the natural history of the disease. Onset of polyp formation and cancer in childhood is very unusual, but has recently been associated with a specific mutation at codon 1309 in exon 15 where a more severe phenotype is sometimes observed. The case histories of two families are reported in which there is childhood onset of polyps in the youngest generation and in one case a carcinoma, in whom mutations have been identified in exon 11 of the APC gene. Several other affected relatives were diagnosed at ages ranging from 5-48 years, some already with a cancer at the time of first screening. Since the aim of screening for colonic polyps is prevention of colonic cancer, family members at risk should be offered genetic assessment and direct mutation testing where this is possible, usually in the early teens. In the absence of a genetic test (the situation in about one third of families) or in a known gene carrier, annual colonoscopy examination is advised from the same age. Clinicians should take note of the family history and be prepared to consider much earlier intervention if symptoms occur in a child with a family history of FAP. Where childhood onset of polyps has occurred, other children at risk in the family must be offered earlier genetic testing and endoscopic surveillance.
相似文献
4.
Managing asthma around peers can be stressful for young adolescents (age 9–14). However, the contexualised coping activities under asthma management-related peer stress is under-investigated. The study aims to explore the peer stress-related coping strategies young adolescents adopt in asthma management. Thirty-four young adolescents were interviewed with semi-structured storytelling protocols. Young adolescents expressed their opinions about four scenarios where the characters had difficulties managing asthma among peers. Interviews were transcribed, and qualitative data were analysed with analytical induction and constant comparison to generate themes that described the coping activities young adolescents adopted in four asthma management scenarios. Young adolescents' responses in each scenario were summarised. The coping activities adolescents adopted were cognitive justifying, explaining, outsourcing and undisclosing. Despite the limitations in a scenario-based qualitative study, the results may be useful for teachers and health professionals in social skill interventions for asthma management in early adolescence. 相似文献
5.
N. J. Crabtree H. Kroger A. Martin H. A. P. Pols R. Lorenc J. Nijs J. J. Stepan J. A. Falch T. Miazgowski S. Grazio P. Raptou J. Adams A. Collings K.-T. Khaw N. Rushton M. Lunt A. K. Dixon J. Reeve 《Osteoporosis international》2002,13(1):48-54
Hip geometry and bone mineral density (BMD) have previously been shown to relate independently to hip fracture risk. Our
objective was to determine by how much hip geometric data improved the identification of hip fracture. Lunar pencil beam scans
of the proximal femur were obtained. Geometric and densitometric values from 800 female controls aged 60 years or more (from
population samples which were participants in the European Prospective Osteoporosis Study, EPOS) were compared with data from
68 female hip fracture patients aged over 60 years who were scanned within 4 weeks of a contralateral hip fracture. We used
Lunar DPX ‘beta’ versions of hip strength analysis (HSA) and hip axis length (HAL) applied to DPX(L) data. Compressive stress
(Cstress), calculated by the HSA software to occur as a result of a typical fall on the greater trochanter, HAL, body mass
index (BMI: weight/(height)2) and age were considered alongside femoral neck BMD (FN-BMD, g/cm2) as potential predictors of fracture. Logistic regression was used to generate predictors of fracture initially from FN-BMD.
Next age, Cstress (as the most discriminating HSA-derived parameter), HAL and BMI were added to the model as potentially independent
predictors. It was not necessary to include both HAL and Cstress in the logistic models, so the entire data set was examined
without excluding the subjects missing HAL measurements. Cstress combined with age and BMI provided significantly better prediction
of fracture than FN-BMD used alone as is current practice, judged by comparing areas under receiver operating characteristic
(ROC) curves (p<0.001, deLong’s test). At a specificity of 80%, sensitivity in identification was improved from 66% to 81%. Identifying women
at high risk of hip fracture is thus likely to be substantially enhanced by combining bone density with age, simple anthropometry
and data on the structural geometry of the hip. HSA might prove to be a valuable enhancement of DXA densitometry in clinical
practice and its use could justify a more pro-active approach to identifying women at high risk of hip fracture in the community.
Received: 16 March 2001 / Accepted: 3 August 2001 相似文献
6.
7.
Krebs JD Elley CR Parry-Strong A Lunt H Drury PL Bell DA Robinson E Moyes SA Mann JI 《Diabetologia》2012,55(4):905-914
Aims/hypothesis
To compare the effectiveness of low-fat high-protein and low-fat high-carbohydrate dietary advice on weight loss, using group-based interventions, among overweight people with type 2 diabetes. 相似文献8.
9.
Morgan C Lunt M Brightwell H Bradburn P Fallow W Lay M Silman A Bruce IN 《Annals of the rheumatic diseases》2003,62(1):15-19
BACKGROUND: There is a wide variation in responses to standard disease modifying antirheumatic drug (DMARD) treatment in rheumatoid arthritis (RA). Whether multidrug resistance, failure to respond to several DMARDs, is a specific entity over and above that expected by chance alone is unclear. OBJECTIVE: To identify patients with RA who demonstrate a multidrug resistant phenotype and to determine what proportion of the variance in drug responses is due to patient related factors. METHODS: Patients with RA (1987 American College of Rheumatology criteria) were identified from clinics at Manchester Royal Infirmary and through the Arthritis Research Campaign National RA Repository. The clinic records were reviewed and multidrug resistance was defined as stopping three or more DMARDs owing to lack of efficacy after an adequate trial of the drug. Logistic regression measured by a random effects model was used to determine the relative contribution of the drug and subject related differences to the multidrug resistance. RESULTS: 265 patients (210 (79.3%) female) were studied. The mean (SD) age and disease duration were 52.2 (12.9) and 10.7 (8.8) years, respectively. Patients had a median (range) of 2 (1-8) DMARD courses. Failure of at least one DMARD due to inefficacy occurred in 105 (40%) and 13 (5%) were multidrug resistant. Overall, 35% of the variance in drug responses was due to between-subject differences (p=0.02). Rheumatoid factor (RF) status contributed significantly to this (OR=2.15, 95% confidence interval (95% CI) 1.00 to 4.62) but explained only 3% of the total variance in drug inefficacy. CONCLUSION: Multidrug resistance occurs in an uncommon (5%) but important subgroup of patients with RA. The between-subject variance is not fully explained by demographics and RF status. Understanding the biological mechanisms that contribute to multidrug resistance may suggest new therapeutic approaches and targets in RA. 相似文献
10.