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Clonidine (10 micrograms X kg-1) reduced by almost 50% the increase in plasma neuropeptide (NPY)-like immunoreactivity (-LI) induced by preganglionic nerve stimulation at 8 Hz. This effect was reversed by yohimbine (1 mg X kg-1) which caused a three-fold increase of the plasma NPY-LI. Prazosin (1 mg X kg-1) had no such effect. Guanethidine (5 mg X kg-1) reduced the stimulation-evoked increase in plasma NPY-LI. It is concluded that the release of NPY-LI evoked by nerve stimulation from sympathetic nerve terminals is controlled by a presynaptic alpha 2-adrenoceptor-mediated mechanism. 相似文献
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WHAN KOOK CHUNG KYU YONG CHOI CHANG DON LEE JIN WU CHUNG HEE SIK SUN KYU WON CHUNG BOO SUNG KIM CHUNG SIK CHUN KYOO HONG CHO SEUNG JO KIM 《Journal of gastroenterology and hepatology》1987,2(1):13-17
Different doses of hepatitis B virus vaccine—prepared by Korea Green Cross Corporation, were given to healthy infants born to HBsAg-negative mothers at birth, 1 and 6 months of age. A dose of 2 μg was administered intradermally in Group A and, in the three other groups, the vaccine was given intramuscularly (i.m.). An adequate follow-up observation was possible for 9 months after birth in 22, 25, 23 and 21 infants in Groups A, B, C and D, respecvely.
Group C (5 μg, i.m.) produced seroconversion most rapidly, showing the highest rate (96%) at 9 months of age. The lowest seroconversion rate (5%) was found at the age of 1 month in Group A subjects, but the rate increased to 91% after a booster dose was given at 6 months of age.
While it can be concluded that a 5 μg i.m. dose of vaccine at 0, 1 and 6 months of age is optimum for the immunization of infants in efficacy and economy, a 2 μg intradermal dose can also be considered as an immunogenic and economical regimen, though the immune response is slower and a special technique is required for immunization. 相似文献
Group C (5 μg, i.m.) produced seroconversion most rapidly, showing the highest rate (96%) at 9 months of age. The lowest seroconversion rate (5%) was found at the age of 1 month in Group A subjects, but the rate increased to 91% after a booster dose was given at 6 months of age.
While it can be concluded that a 5 μg i.m. dose of vaccine at 0, 1 and 6 months of age is optimum for the immunization of infants in efficacy and economy, a 2 μg intradermal dose can also be considered as an immunogenic and economical regimen, though the immune response is slower and a special technique is required for immunization. 相似文献
5.
JO MANION RN MA CNAA 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1986,15(2):103-108
A documentation system that facilitates accurate and complete recording is needed by every obstetric/neonatal nursing service. Developing an individualized system is a major undertaking. However, specific steps can be taken to ease the process. These steps are described, beginning with the assessment phase and concluding with evaluation. 相似文献
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Occurrence of anti-C1q antibodies in IgA nephropathy 总被引:1,自引:0,他引:1
Gunnarsson I; Ronnelid J; Lundberg I; Jacobson S 《Nephrology, dialysis, transplantation》1997,12(11):2263-2268
Background: The pathogenic mechanisms and the antigens
involved in the establishment and progress of IgA nephropathy are unknown.
As antibodies against C1q have been reported to correlate with SLE
nephritis, we analysed the occurrence of these antibodies in IgA
nephropathy in order to investigate the possibility of pathogenetic
similarities in these renal disorders. Methods: The
occurrence of IgA- and IgG anti-C1q antibodies (anti-C1q) were determined
by ELISA in patients with IgA nephropathy (n=36) and SLE nephritis (n=37),
diseases both known to be associated with circulating immune complexes.
Levels of these antibodies were also determined in two other glomerular
diseases, i.e. idiopathic membranous glomerulo-nephritis (n=7) and minimal
change disease (n=2), in which circulating immune complexes are usually not
present, and in 40 healthy controls. Results: IgA
anti-C1q was observed in increased titres in 11/36 of the patients with IgA
nephropathy, in 2/37 of the patients with SLE nephritis (both with
proliferative disease) and in 1/9 of the patients with membranous and
minimal change disease (P<0.001). Increased titres of IgG anti-C1q
were observed in 1/36 of the patients with IgA nephropathy, in 17/37 of the
patients with SLE nephritis and in 0/9 of the patients with membranous and
minimal change disease (P<0.001). There were no correlations between
the levels of anti-C1q antibodies and clinical parameters such as degree of
proteinuria, haematuria, or renal function. Nor was there any correlation
to the concentration of C3a and the terminal complement complex (TCC) in
patients with IgA nephropathy. Conclusions: The
occurrence of anti-C1q antibodies in both IgA nephropathy and SLE
nephritis, albeit of different predominating isotypes, indicates the
possibility of a similar pathogenic mechanism involved in these renal
disorders. The occurrence of IgA anti-C1q antibodies in patients with IgA
nephropathy has to our knowledge not previously been reported. 相似文献
9.
G Lindstedt E Nystr?m P A Lundberg E Johansson R Eggertsen 《Scandinavian journal of primary health care》1992,10(3):192-197
In order to assess the diagnostic outcome of a screening for primary hyperparathyroidism (PHPT) in an elderly population, we determined ionized calcium in serum from 368 individuals participating in a health control at M?lnlycke Primary Care Centre (200 women, 168 men; age range 75-95 years); four-fifths of the individuals living in their homes, the remainder in homes for aged or nursing homes. Intact parathyroid hormone was determined in the samples with oinized calcium concentration greater than mean + 3SD of the truncated population sample, and these individuals were also recalled for another blood sample. Moderate hypercalcaemia, probably due to PHPT, was found in eight individuals (2% of the complete sample, 3% of the women), five having neuropsychiatric or neuromuscular symptoms consistent with PHPT. Surgical intervention is probably indicated in only a small proportion of elderly patients. We conclude that optimal benefits in relation to costs of screening for PHPT in old people will depend on the availability of a safe and simple pharmacological treatment that could determine any causal relationship between hypercalcaemia and symptoms. 相似文献
10.
M Frankenhaeuser U Lundberg M Rauste von Wright J von Wright G Sedvall 《Pharmacology, biochemistry, and behavior》1986,24(6):1521-1525
Concentrations of the serotonin metabolite 5-hydroxyindole acetic acid (5-HIAA), the dopamine metabolite homovanillic acid (HVA) and the noradrenaline metabolite 4-hydroxy-3-methoxyphenyl glycol (HMPG) were determined in urine samples from healthy male and female students by mass fragmentography. Urine samples were obtained after a demanding examination (mental stress) and a day of ordinary school work (control condition). Self-ratings were obtained of feelings induced by the examination, and of habitual psychosomatic symptoms. The results for both sexes showed that the examination stress induced a significant increase of HVA and HMPG excretion, but not of 5-HIAA. The males excreted significantly more of each of the metabolites than the females. The pattern of correlations between metabolite levels and psychological and psychosomatic variables were strikingly different for the two sexes. 相似文献