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Caballero T Concepcion Lopez-Serrano M Lopez-Trascasa M 《Annals of internal medicine》2000,133(10):837-8; author reply 839
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Perez-Calle JL Marin-Jimenez I Lopez-Serrano P Gisbert JP Pena AS Fernandez-Rodriguez C 《Digestive diseases and sciences》2008,53(2):486-489
Macro-creatine-kinases are isoenzymes of creatinine-kinases (CK). They have been classified in two types: type 1 (CK bound
to an immunoglobulin) and type 2 (an oligomeric mitochondrial CK). CK type 1 has been found in patients with ulcerative colitis
(UC) but not in Crohn’s disease (CD). However, there are no studies evaluating macro-creatinkinase prevalence in inflammatory
bowel disease (IBD). We included 159 consecutive patients (72 UC, 85 CD; 2 indeterminate colitis). Creatin-kinase total activity
and isoenzymes activities were determined. Twelve (16.7%) patients with UC and one of the two patients with indeterminate
colitis had serum macro-creatinkinase type 1 while no CD patients displayed this macromolecule (P < 0,001). Sensitivity, specificity, positive and negative predictive value, and positive and negative likelihood ratio were
calculated for ulcerative colitis versus Crohn’s disease diagnosis, being 16.7, 98.9, 92.3, 59, 14.5, and 0.84% respectively.
There was no correlation with age, gender, time from diagnosis, associated diseases, concomitant medication or disease activity.
In conclusion our data suggests that the presence of macro-CK in IBD favors the diagnosis of ulcerative colitis. Further studies
are necessary to understand the significance of this finding in a subset of patients with IBD. 相似文献
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