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排序方式: 共有163条查询结果,搜索用时 15 毫秒
1.
Yu. B. Lishmanov L. V. Maslova L. N. Maslov E. N. Dan'shina 《Bulletin of experimental biology and medicine》1993,116(2):974-976
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N
o
8, pp. 175–176, August, 1993 相似文献
2.
Yu. B. Lishmanov L. N. Maslov N. V. Naryzhnaya 《Bulletin of experimental biology and medicine》1997,123(3):239-241
Immobilization induces stress damage to the heart. DAGO, an agonist of μ-opiate receptors potentiates, while an agonist of
peripheral μ-opiate receptors prevents this damage. Naltrexone reduces, while methylnaltrexone, an inhibitor of peripheral
μ-opiate receptors, potentiates the stress-induced damage to the heart. Other opiate ligands have no effect on heart damage.
It is suggested that the stress-induced damage to the heart is promoted by activation of central μ-opiate receptors and prevented
by stimulation of peripheral μ-opiate receptors.
Translated fromByulleten'Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 3, pp. 276–278, March, 1997 相似文献
3.
S. A. Afanas'ev E. D. Alekseeva Yu. B. Lishmanov 《Bulletin of experimental biology and medicine》1994,118(6):1273-1275
Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate
receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for
each animal in chambers at −10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain
ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were
performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow
induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components,
and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate
receptors.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 582–584, December, 1994
Presented by R. S. Karpov, Member of the Russian Academy of Medical Sciences 相似文献
4.
Yu. B. Lishmanov B. Yu. Kondrat’ev L. N. Maslov N. V. Naryzhnaya 《Bulletin of experimental biology and medicine》1997,123(2):130-132
Acute cold exposure (−20°C, 4 h) induces a transient decrease in the ventricular fibrillation threshold without morphological
and radionuclide signs of irreversible damage to cardiomyocytes. The agonist of μ-receptors DAGO, which reduces adrenoreactivity
of the myocardium, prevents the decrease in the ventricular fibrillation threshold induced by acute cold exposure.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 2, pp. 154–157, February, 1997 相似文献
5.
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7.
Lishmanov AY Maslov LN Lasukova TV Crawford D Wong TM 《Bulletin of experimental biology and medicine》2007,143(2):187-190
Intravenous pretreatment with κ-opioid receptor antagonist (−)-U-50,488 (1 mg/kg) improved heart resistance to the arrhythmogenic
effect of coronary occlusion and reperfusion. Selective κ1-opioid receptor antagonist norbinaltorphimine and nonselective blocker of peripheral opioid receptors methylnaloxone abolished
this antiarrhythmic effect. Preliminary blockade of protein kinase C with chelerythrine or inhibition of ATP-dependent K+ channels (KATP channels) with glybenclamide abolished the antiarrhythmic effect of κ-opioid receptor activation. Selective inhibitor of
sarcolemmal KATP channels did not modulate the κ-opioid receptor-mediated increase in cardiac electrical stability. Our results suggest that
protein kinase C and mitochondrial KATP channels play an important role in the antiarrhythmic effect associated with activation of peripheral κ-opioid receptors.
__________
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 2, pp. 145–148, February, 2007 相似文献
8.
Ekaterina S. Prokudina Boris K. Kurbatov Konstantin V. Zavadovsky Alexander V. Vrublevsky Natalia V. Naryzhnaya Yuri B. Lishmanov Leonid N. Maslov Peter R. Oeltgen 《Current Cardiology Reviews》2021,17(2):188
The purpose of the review is the analysis of clinical and experimental data on the etiology and pathogenesis of takotsubo syndrome (TS). TS is characterized by contractile dysfunction, which usually affects the apical region of the heart without obstruction of coronary artery, moderate increase in myocardial necrosis markers, prolonged QTc interval (in 50% of patients), sometimes elevation of ST segment (in 19% of patients), increase N-Terminal Pro-B-Type Natriuretic Peptide level, microvascular dysfunction, sometimes spasm of the epicardial coronary arteries (in 10% of patients), myocardial edema, and life-threatening ventricular arrhythmias (in 11% of patients). Stress cardiomyopathy is a rare disease, it is observed in 0.6 - 2.5% of patients with acute coronary syndrome. The occurrence of takotsubo syndrome is 9 times higher in women, who are aged 60-70 years old, than in men. The hospital mortality among patients with TS corresponds to 3.5% - 12%. Physical or emotional stress do not precede disease in all patients with TS. Most of patients with TS have neurological or mental illnesses. The level of catecholamines is increased in patients with TS, therefore, the occurrence of TS is associated with excessive activation of the adrenergic system. The negative inotropic effect of catecholamines is associated with the activation of β2 adrenergic receptors. An important role of the adrenergic system in the pathogenesis of TS is confirmed by studies which were performed using 125I-metaiodobenzylguanidine (125I -MIBG). TS causes edema and inflammation of the myocardium. The inflammatory response in TS is systemic. TS causes impaired coronary microcirculation and reduces coronary reserve. There is a reason to believe that an increase in blood viscosity may play an important role in the pathogenesis of microcirculatory dysfunction in patients with TS. Epicardial coronary artery spasm is not obligatory for the occurrence of TS. Cortisol, endothelin-1 and microRNAs are challengers for the role of TS triggers. A decrease in estrogen levels is a factor contributing to the onset of TS. The central nervous system appears to play an important role in the pathogenesis of TS. 相似文献
9.
10.
Lishmanov YB Maslov LN Krylatov AV Solenkova NV Stakheev DL 《Bulletin of experimental biology and medicine》2003,135(1):55-58
During aconitine-induced arrhythmias the antiarrhythmic effect of DALDA (Tyr-D-Arg-Phe-Lys-NH2) and nociceptin (orphanin FQ) administered intravenously depended on activation of nitric oxide synthase. KATP channels were not involved in the realization of this effect. Endogenous prostanoids played a minor role in the antiarrhythmic effect of nociceptin and did not contribute to the protective influence of DALDA. The antiarrhythmic effect of orphanin FQ administered intravenously did not depend on functional activity of the autonomic nervous system. However, the effect of orphanin FQ after intracerebroventricular infusion was determined by changes in the state of this system. 相似文献