全文获取类型
收费全文 | 576篇 |
免费 | 85篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 32篇 |
妇产科学 | 8篇 |
基础医学 | 83篇 |
口腔科学 | 3篇 |
临床医学 | 75篇 |
内科学 | 112篇 |
皮肤病学 | 7篇 |
神经病学 | 63篇 |
特种医学 | 4篇 |
外科学 | 94篇 |
综合类 | 11篇 |
预防医学 | 98篇 |
眼科学 | 2篇 |
药学 | 33篇 |
中国医学 | 1篇 |
肿瘤学 | 23篇 |
出版年
2024年 | 2篇 |
2023年 | 8篇 |
2022年 | 23篇 |
2021年 | 28篇 |
2020年 | 24篇 |
2019年 | 22篇 |
2018年 | 30篇 |
2017年 | 24篇 |
2016年 | 18篇 |
2015年 | 30篇 |
2014年 | 22篇 |
2013年 | 32篇 |
2012年 | 47篇 |
2011年 | 43篇 |
2010年 | 14篇 |
2009年 | 16篇 |
2008年 | 20篇 |
2007年 | 22篇 |
2006年 | 35篇 |
2005年 | 26篇 |
2004年 | 28篇 |
2003年 | 22篇 |
2002年 | 19篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 5篇 |
1996年 | 2篇 |
1994年 | 8篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 3篇 |
1990年 | 7篇 |
1989年 | 2篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1983年 | 7篇 |
1982年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1974年 | 5篇 |
1973年 | 3篇 |
1972年 | 6篇 |
1971年 | 2篇 |
1967年 | 2篇 |
1943年 | 1篇 |
1902年 | 1篇 |
排序方式: 共有661条查询结果,搜索用时 31 毫秒
1.
M J Hershman R I Swift D T Reilly W A Logan J M Sackier H Gompertz J Horner N W Baker C B Wood 《Journal of the Royal College of Surgeons of Edinburgh》1990,35(1):29-32
This study compared one dose of cefotetan with three doses of piperacillin as prophylaxis against wound infection in 153 patients undergoing elective colorectal surgery. The patients were randomized into two groups: the first received 2 g cefotetan intravenously with induction of anaesthesia (n = 75), and the second received three doses of 2 g piperacillin (n = 78). Wound infection was defined as the presence of an abscess or discharging pus from the wound. In the cefotetan group there were 14 (19%) wound infections and 13 (17%) in the piperacillin group. There were three septic deaths, one in the cefotetan group and two in the piperacillin group. Both groups were comparable with regard to age, sex, nature of pathology and pre- and perioperative risk factors. No significant haematological or biochemical abnormalities were detected. The only adverse reaction was one patient who had an allergic reaction (rash) to piperacillin. These data suggest that single-dose cefotetan is as effective as triple-dose piperacillin in prophylaxis against infection in elective colorectal surgery. 相似文献
2.
James C Slaughter Thomas Lumley Lianne Sheppard Jane Q Koenig Gail G Shapiro 《Annals of allergy, asthma & immunology》2003,91(4):346-353
BACKGROUND: Exposure to air pollutants has been investigated as a possible cause of asthma attacks in children. OBJECTIVE: To investigate the short-term effects of air pollutants on a panel of 133 children with asthma who enrolled in the Childhood Asthma Management Program. METHODS: During screening, the children completed daily diary cards for an average of 58 days to indicate their medication use and asthma severity. We used ordinal logistic regression to compare the odds of a more serious relative to a less serious asthma attack, and we used a Poisson model to analyze medication use. In both analyses we accommodate dependence in the data and different periods of observation for study subjects. RESULTS: Our results indicate that a 10-microg/m3 increase in particulate matter less than or equal to 2.5 microm (PM2.5) lagged 1 day was associated with a 1.20 times increased odds of having a more serious asthma attack [95% confidence interval (CI), 1.05 to 1.37] and a 1.08-fold increase in medication use (95% CI, 1.01 to 1.15). A 10-microg/m3 increase in particulate matter less than or equal to 10 microm (PM10) increased the odds of a more serious asthma attack (odds ratio = 1.12; 95% CI, 1.04 to 1.22) and also increased medication use (relative risk = 1.05; 95% CI, 1.00 to 1.09). CONCLUSIONS: Increases in PM2.5 and PM10 are significantly associated with an increased risk of more severe asthma attacks and medication use in Seattle area children with asthma. We also found associations with carbon monoxide, but we believe that carbon monoxide is a marker for exposure to combustion byproducts. 相似文献
3.
Modifiers of non-specific symptoms in occupational and environmental syndromes. 总被引:7,自引:1,他引:6 下载免费PDF全文
Many occupational and environmental health hazards present as an increased reporting of non-specific symptoms such as headache, backache, eye and respiratory irritation, tiredness, memory problems, and poor concentration. The pattern and number of such symptoms is surprisingly constant from hazard to hazard suggesting that common psychological and social factors, not directly related to the exposure may be involved. A recent workshop (see acknowledgements) was held to review the pattern of symptoms in varying hazardous situations and the psychological mechanisms behind the genesis and maintenance of symptoms. The involvement of both direct physicochemical and psychological mechanisms in symptom generation and reporting in any situation was discussed and is reported here. A model that identifies the issues that need to be considered in any epidemiological study based on the incidence or prevalence of non-specific symptoms is proposed. 相似文献
4.
Rutger L. van Bezooijen Marco C. DeRuiter Nathalie Vilain Rui M. Monteiro Annemieke Visser Lianne van der Wee‐Pals Conny J. van Munsteren Pancras C.W. Hogendoorn Michel Aguet Christine L. Mummery Socrates E. Papapoulos Peter Ten Dijke Clemens W.G.M. Löwik 《Developmental dynamics》2007,236(2):606-612
Spatial-temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries. In the present study, we show that SOST, a Dan family member reported to antagonize BMP and Wnt activity, is expressed within the medial vessel wall of the great arteries containing smooth muscle cells. The ascending aorta, aortic arch, brachiocephalic artery, common carotids, and pulmonary trunk were all associated with SOST expressing smooth muscle cells, while the heart itself, including the valves, and more distal arteries, that is, pulmonary arteries, subclavian arteries, and descending aorta, were negative. SOST was expressed from embryonic day 15.5 up to the neonatal period. SOST expression, however, did not correspond with inhibition of Smad-dependent BMP activity or beta-catenin-dependent Wnt activity in the great arteries. Activity of both signaling pathways was already down-regulated before induction of SOST expression. 相似文献
5.
David Gompertz Patricia A. Goodey Hazel Thom George Russell Alan W. Johnston David H. Mellor Murdoch W. MacLean Marie E. Ferguson-Smith Malcolm A. Ferguson-Smith 《Clinical genetics》1975,8(4):244-250
In a family with a history of two neonatal deaths, propionicacidaemia was diagnosed retrospectively from stored plasma as the cause of the second death during the mother's next pregnancy. Amniocentesis was performed and a culture of amniotic cells was assayed for propionyl CoA carboxylase activity. The absence of any detectable propionyl CoA carboxylase activity allowed the prenatal diagnosis of propionicacidaemia to be made. Treatment with biotin and a modified aminoacid diet was started in the immediate postnatal period. Investigation of propionyl CoA carboxylase in leucocytes from the parents, siblings and other relations of the patient failed to demonstrate intermediate enzyme activities in even the parents, who were presumably heterozygotes for this condition. 相似文献
6.
Vivolo-Kantor Alana M. Niolon Phyllis Holditch Estefan Lianne Fuino Le Vi Donna Tracy Allison J. Latzman Natasha E. Little Todd D. Lang Kyle M. DeGue Sarah Tharp Andra Teten 《Prevention science》2021,22(2):162-162
Prevention Science - The article “Middle School Effects of the Dating Matters® Comprehensive Teen Dating Violence Prevention Model on Physical Violence, Bullying, and Cyberbullying: a... 相似文献
7.
8.
Yanni Li Lianne M. Nieuwenhuis Michiel D. Voskuil Ranko Gacesa Shixian Hu Bernadien H. Jansen Werna T. U. Venema Bouke G. Hepkema Hans Blokzijl Henkjan J. Verkade Ton Lisman Rinse K. Weersma Robert J. Porte Eleonora A. M. Festen Vincent E. de Meijer 《American journal of transplantation》2021,21(9):3133-3147
Thrombosis after liver transplantation substantially impairs graft- and patient survival. Inevitably, heritable disorders of coagulation originating in the donor liver are transmitted by transplantation. We hypothesized that genetic variants in donor thrombophilia genes are associated with increased risk of posttransplant thrombosis. We genotyped 775 donors for adult recipients and 310 donors for pediatric recipients transplanted between 1993 and 2018. We determined the association between known donor thrombophilia gene variants and recipient posttransplant thrombosis. In addition, we performed a genome-wide association study (GWAS) and meta-analyzed 1085 liver transplantations. In our donor cohort, known thrombosis risk loci were not associated with posttransplant thrombosis, suggesting that it is unnecessary to exclude liver donors based on thrombosis-susceptible polymorphisms. By performing a meta-GWAS from children and adults, we identified 280 variants in 55 loci at suggestive genetic significance threshold. Downstream prioritization strategies identified biologically plausible candidate genes, among which were AK4 (rs11208611-T, p = 4.22 × 10−05) which encodes a protein that regulates cellular ATP levels and concurrent activation of AMPK and mTOR, and RGS5 (rs10917696-C, p = 2.62 × 10−05) which is involved in vascular development. We provide evidence that common genetic variants in the donor, but not previously known thrombophilia-related variants, are associated with increased risk of thrombosis after liver transplantation. 相似文献
9.
Rachel Vanderkruik Lianne Gonsalves Grace Kapustianyk Tomas Allen Lale Say 《Bulletin of the World Health Organization》2021,99(5):359
ObjectiveTo systematically review the literature on the mental health of adolescents associated with sexual and reproductive outcomes, and compare the mental health outcomes with that of other age groups.MethodsWe searched seven databases for relevant peer-reviewed articles published between 1 January 2010 and 25 April 2019. Our inclusion criteria required that the study included age-disaggregated data on adolescents, and focused and assessed mental health outcomes associated with pregnancy or sexually transmitted infections. We extracted data on the specific health event, the mental health outcome and the method of measuring this, and comparisons with other age groups.FindingsAfter initially screening 10 818 articles by title and abstract, we included 96 articles in our review. We observed that a wide-ranging prevalence of mental ill-health has been reported for adolescents. However, most studies of mental health during pregnancy did not identify an increased risk of depression or other mental disorders among adolescents compared with other age groups. In contrast, the majority of studies conducted during the postpartum period identified an increased risk of depression in adolescents compared with other age groups. Three studies reported on mental health outcomes following abortion, with varying results. We found no studies of the effect of sexually transmitted infections on mental health among adolescents.ConclusionWe recommend that sexual and reproductive health services should be accessible to adolescents to address their needs and help to prevent any adverse mental health outcomes. 相似文献