青蒿琥酯皮肤擦剂在小鼠和兔体内的药代动力学研究

将青蒿琥酯溶于苯二甲酸二甲酯,加适量氨酮制成皮肤擦剂。给兔脱毛后,皮肤涂抹此擦剂25mg/kg后,血药浓度达峰时间平均为2 h,峰浓度平均为1.80μg/ml。药物在兔体内平均驻留时间为3.54 h,清除半衰期约为2.46 h。给小鼠脱毛皮肤涂抹擦剂6.7,31.3和71.4 mg/kg,血药浓度在给药后0.5～4 h达高峰,峰浓度分别为0.82,2.05和7.11μg/ml,体内药物平均驻留时间为3.39,2.79及3.54 h,清除半衰期为2.35,1.93及2.45 h。可见,给兔及小鼠皮肤擦剂后,青蒿琥酯吸收良好,血药浓度维持时间较长。     

Effect of heavy metals on the aromatic system of benzoic acid

Raman and infrared spectra were made of mercury^II, cadmium and aluminum benzoates To better understand the mechanism of toxic action of heavy metals, comparisons were made of the effects of mercury^I, mercury^II, lead^II, cadmium barium, strontium, copper^II, aluminum, iron^III zinc, magnesium, calcium, yttrium, lanthanum^III neodymium^III, dysprosium^III, luthetium^III, lithium sodium, and potassium on the aromatic system of benzoic acid. Benzoic acid was considered to be model compound, representing a wide group of aromatic ligands present in enzymes. Oscillation (Raman, IR) and electronic (UV) spectroscopy methods were applied.Heavy toxic metals, particularly Hg^I, Hg^II, and Pb^II in contrast to Ca, Mg, Al, Fe^III, Zn, Y, and Ln^III perturb the aromatic system of benzoic acid by deforming the uniforming distribution of electron charges in the ring.