排序方式: 共有10条查询结果,搜索用时 15 毫秒
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Arnold Danielle E. Chellapandian Deepak Parikh Suhag Mallhi Kanwaldeep Marsh Rebecca A. Heimall Jennifer R. Grossman Debra Chitty-Lopez Maria Murguia-Favela Luis Gennery Andrew R. Boulad Farid Arbuckle Erin Cowan Morton J. Dvorak Christopher C. Griffith Linda M. Haddad Elie Kohn Donald B. Notarangelo Luigi D. Pai Sung-Yun Puck Jennifer M. Pulsipher Michael A. Torgerson Troy Kang Elizabeth M. Malech Harry L. Leiding Jennifer W. 《Journal of clinical immunology》2022,42(5):1026-1035
Journal of Clinical Immunology - Granulocyte transfusions are sometimes used as adjunctive therapy for the treatment of infection in patients with chronic granulomatous disease (CGD). However,... 相似文献
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Jennifer W. Leiding Beatriz E. Marciano Christa S. Zerbe Suk See DeRavin Harry L. Malech Steven M. Holland 《Journal of clinical immunology》2013,33(4):725-730
Chronic granulomatous disease is a rare immunodeficiency due to defects in the phagocyte NADPH oxidase. The X-linked form (gp91 phox deficiency) accounts for about 70 % of cases; autosomal recessive p47 phox deficiency accounts for about 25 % of cases. We identified a 10 % incidence of diabetes in p47 phox deficient CGD, but none in X-linked CGD. Renal and cardiovascular diseases were also higher in p47 phox deficiency. p47 phox deficient CGD has non-infectious morbidities distinct from those in X-linked CGD. 相似文献
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Jessica R. Trotter Panida Sriaroon David Berman Aleksandra Petrovic Jennifer W. Leiding 《Journal of clinical immunology》2014,34(1):49-52
Sporothrix schenckii lymphadenitis was identified in a 33 month old male with X-linked chronic granulomatous disease (CGD). S. schenckii is a dimorphic catalase producing fungus found in the soil of temperate and tropical climates. Host defense against S. schenckii relies primarily on innate and cellular responses and gp91phox?/? mice are susceptible to disseminated infection. This case represents the first report of susceptibility to sporotrichosis in a patient with CGD. 相似文献
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Panida Sriaroon Araceli Elizalde Elena E. Perez Jennifer W. Leiding Grace M. Aldrovandi John W. Sleasman 《Journal of clinical immunology》2014,34(1):39-41
A 16-year old boy with chronic granulomatous disease (CGD) developed Psychrobacter immobilis septicemia during a course of fulminant hepatic failure. The patient died despite aggressive management with antimicrobials and corticosteroids. While Psychrobacter immobilis rarely affects humans, it should be considered an organism that can cause sepsis in patients with CGD. 相似文献
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Jennifer W. Leiding Satoshi Okada David Hagin Mario Abinun Anna Shcherbina Dmitry N. Balashov Vy H.D. Kim Adi Ovadia Stephen L. Guthery Michael Pulsipher Desa Lilic Lisa A. Devlin Sharon Christie Mark Depner Sebastian Fuchs Annet van Royen-Kerkhof Caroline Lindemans Aleksandra Petrovic Troy R. Torgerson 《The Journal of allergy and clinical immunology》2018,141(2):704-717.e5
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Thom Leiding Jun Wang Jonas Martinsson William F. DeGrado Sindra Peterson ?rsk?ld 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(35):15409-15414
The M2 protein is a small, single-span transmembrane (TM) protein from the influenza A virus. This virus enters cells via endosomes; as the endosomes mature and become more acidic M2 facilitates proton transport into the viral interior, thereby disrupting matrix protein/RNA interactions required for infectivity. A mystery has been how protons can accumulate in the viral interior without developing a large electrical potential that impedes further inward proton translocation. Progress in addressing this question has been limited by the availability of robust methods of unidirectional insertion of the protein into virus-like vesicles. Using an optimized procedure for reconstitution, we show that M2 has antiporter-like activity, facilitating K+ or Na+ efflux when protons flow down a concentration gradient into the vesicles. Cation efflux is very small except under conditions mimicking those encountered by the endosomally entrapped virus, in which protons are flowing through the channel. This proton/cation exchange function is consistent with the known high proton selectivity of the channel. Thus, M2 acts as a proton uniporter that occasionally allows K+ to flow to maintain electrical neutrality. Remarkably, as the pH inside M2-containing vesicles (pHin) decreases, the proton channel activity of M2 is inhibited, but its cation transport activity is activated. This reciprocal inhibition of proton flux and activation of cation flux with decreasing pHin first allows accumulation of protons in the early stages of acidification, then trapping of protons within the virus when low pHin is achieved. 相似文献
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This study was done to determine whether the Minnesota Multiphasic Personality Inventory (MMPI) aided in selection of appropriate lumbosacral fusion candidates, compared with those selected without an MMPI. Postoperative end-result ratings were done, categorizing patients into two groups: one group of 62 patients with a preoperative MMPI and a second group of 23 patients with no preoperative MMPI. Thirty patients with normal MMPIs, strong objective indications for initial surgery, and absence of compensation and/or litigation factors had 88% good or excellent end-results. Twenty-three patients had surgery without MMPI evaluation. Of 21 available for follow-up, 86% had good or excellent end-results. "Warning" physical signs aided selection of appropriate surgical candidates in the patients who did not have an MMPI. 相似文献
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Alexander Vargas-Hernández Emily M. Mace Ofer Zimmerman Christa S. Zerbe Alexandra F. Freeman Sergio Rosenzweig Jennifer W. Leiding Troy Torgerson Matthew C. Altman Edith Schussler Charlotte Cunningham-Rundles Ivan K. Chinn Alexandre F. Carisey Imelda C. Hanson Nicholas L. Rider Steven M. Holland Jordan S. Orange Lisa R. Forbes 《The Journal of allergy and clinical immunology》2018,141(6):2142-2155.e5
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Leiding JW Freeman AF Marciano BE Anderson VL Uzel G Malech HL DeRavin S Wilks D Venkatesan AM Zerbe CS Heller T Holland SM 《Clinical infectious diseases》2012,54(5):694-700
Liver abscesses in chronic granulomatous disease (CGD) are typically difficult to treat and often require surgery. We describe 9 X-linked CGD patients with staphylococcal liver abscesses refractory to conventional therapy successfully treated with corticosteroids and antibiotics. Corticosteroids may have a role in treatment of Staphylococcus aureus liver abscesses in CGD. 相似文献
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