全文获取类型
收费全文 | 257篇 |
免费 | 3篇 |
专业分类
耳鼻咽喉 | 5篇 |
妇产科学 | 49篇 |
基础医学 | 142篇 |
口腔科学 | 1篇 |
临床医学 | 14篇 |
内科学 | 19篇 |
皮肤病学 | 2篇 |
神经病学 | 11篇 |
外科学 | 1篇 |
预防医学 | 3篇 |
眼科学 | 9篇 |
药学 | 3篇 |
肿瘤学 | 1篇 |
出版年
2016年 | 3篇 |
2015年 | 3篇 |
2014年 | 2篇 |
2013年 | 5篇 |
2012年 | 7篇 |
2011年 | 6篇 |
2010年 | 2篇 |
2008年 | 7篇 |
2007年 | 5篇 |
2006年 | 6篇 |
2005年 | 3篇 |
2004年 | 7篇 |
2003年 | 5篇 |
2002年 | 11篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 3篇 |
1997年 | 2篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1977年 | 1篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1970年 | 2篇 |
1969年 | 3篇 |
1968年 | 3篇 |
1967年 | 2篇 |
1966年 | 1篇 |
1957年 | 1篇 |
1937年 | 1篇 |
1934年 | 3篇 |
1933年 | 11篇 |
1932年 | 10篇 |
1931年 | 8篇 |
1930年 | 9篇 |
1929年 | 8篇 |
1928年 | 14篇 |
1927年 | 11篇 |
1926年 | 12篇 |
1925年 | 13篇 |
1924年 | 13篇 |
1923年 | 14篇 |
1922年 | 9篇 |
1921年 | 3篇 |
排序方式: 共有260条查询结果,搜索用时 265 毫秒
1.
The aim of the study was to use the appraisal model of stress to compare hemodialysis (HD) and continuous peritoneal dialysis (CAPD) patients with special focus on the perception of end-stage renal disease and subsequent emotional profile and health related quality of life (HQoL) in. We hypothesize that different circumstances related to both modes of therapies will result in dissimilar perception of chronic illness with subsequent changes in emotional profile and heath related quality of life. The total of 88 patients with end stage renal disease (ESRD) enrolled in hemodialysis (n=52; HD) or continuous peritoneal dialysis (n=36; CAPD) were given a battery of psychological tests: The Profile of Mood States, The Nottingham Health Profile, The Stress Situation Assessment Questionnaire, The Social Appreciation Questionnaire and The Situation and Trait and Anxiety Inventory. All patients perceived ESRD in terms of a loss and a threat. Moreover, CAPD patients evaluated ESRD as a challenge. Despite different perception of ESRD no significant difference in the level of fear, anxiety or emotional profile was found. Both HD and CAPD patient were reported more fatigue/inertia and confusion/bewilderment than control groups. The main health related complaints were similar in both ESRD patients with major complaints of sleeping disturbances, motor limitations and lack of energy. From the psychological point of view, CAPD treatment seems more like challenge to the enrolled patient which is positive outcome. Despite different appraisal of stress mood and health related complaints were similar in both groups. This may be a result of optimal regulation of cognitive perception of the stress depending on the circumstances of therapy. 相似文献
2.
Evaluation of angiogenesis, p-53 tissue protein expression and serum VEGF in patients with endometrial cancer 总被引:5,自引:0,他引:5
Mazurek A Pierzyński P Kuć P Kopinski P Terlikowski S Niklińska W Trojan J Laudański T 《Neoplasma》2004,51(3):193-197
Endometrial carcinoma occurs mostly in post-menopausal women. Classical methods of prognostication, as FIGO stage and histopathologic grade, could be improved by applying additional techniques, utilizing molecular biology and immunochemistry. p-53 tumor suppressor gene, the most commonly mutated gene in human cancers has been shown to play an important role in the biology of gynecologic carcinomas. Angiogenesis, a process of formation of new vessels, being connected to tumors progression and metastatic potential was shown to be linked with tumor suppressor genes expression. The aim of the study was to evaluate relationships between intensity of tumor angiogenesis, serum levels of Vascular Endothelial Growth Factor (VEGF) and tissue p-53 protein expression in endometrial adenocarcinoma. Angiogenic Point's Density (APD) was calculated in hot spots areas using the morphometric appliance. For detection of p53 protein in tumor samples, LSAB + Kit Alkaline Phosphatase (DAKO) was used. VEGF levels were assessed in patient's blood sampled before the operation. Overexpression of p53 protein was found in tumor tissue in 35.2% of cases and mean angiogenic points density was greater in p53 positive cases. Serum levels of VEGF were above the cut off level in 54.5% of patients, in those cases angiogenesis was also elevated. In cases of p53 overexpression, VEGF levels tended to be greater as compared with p53 negative cases. In conclusion, our study demonstrated that angiogenesis was more intensive in p53 positive cases, confirming the hypothesis of tumor suppressor-gene regulation of the process of neovascularization. Serum levels of VEGF were borderline-significantly higher in cases of p53 overexpression, they were also correlated to the angiogenesis. Joint assessment of angiogenesis and tumor suppressor genes expression may contribute to reliable evaluation of the biology of endometrial carcinoma. 相似文献
3.
4.
5.
6.
7.
8.
Ohne Zusammenfassung 相似文献
9.
Möllers Carl Lewin Van Eweyk Seiffert Max Steiger Kleemann Kehrer Ötvös Neukirch Toenniessen Scholz Simmel Beltz Ebstein Heyer Planner J. Bauer Lauda Nonnenbruch Klieneberger 《Journal of molecular medicine (Berlin, Germany)》1922,1(28):1431-1439
Ohne Zusammenfassung 相似文献