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排序方式: 共有659条查询结果,搜索用时 15 毫秒
1.
Sarala Rajajee Malathi Sathyasekaran Janani Shankar Latha Dhathathri Anandnathan 《Indian journal of pediatrics》2002,69(10):821-822
A 5-year-old boy presented with history of failure to thrive from infancy. There was a history of one sibling death due to
similar problems and history of severe abortions in the mother. Routine examination of peripheral smear revealed more than
50% acanthocytes. Based on this tests were streamlined to doing lipid profile and Lipo protein electrophoresis which revealed
hypolipidemia and absent Β hypo protein band. Jejuna) mucosal biopsy confirmed the diagnosis of A Beta Lipo proteinemia which
revealed lipid laden enterocytes. This case illustrates the importance of simple tests like peripheral smear examination in
streamlining further tests in the diagnosis of major diseases. 相似文献
2.
Keloid fibroblast responsiveness to epidermal growth factor and activation of downstream intracellular signaling pathways. 总被引:8,自引:0,他引:8
Latha Satish Mary Babu Kien T Tran Patricia A Hebda Alan Wells 《Wound repair and regeneration》2004,12(2):183-192
Keloids, which overgrow the boundaries of the original injury, represent aberrations in the fundamental process of wound healing that include over-abundant cell in-migration, cell proliferation, and inflammation, as well as increased extracellular matrix synthesis and defective remodeling. To understand the key events that result in the formation of these abnormal scars would open new avenues for better understanding of excessive repair, and might provide new therapeutic options. We examined epidermal growth factor receptor (EGFR)-induced cell motility in keloid fibroblasts, as this receptor initiates cell migration during normal wound repair. We show that keloid fibroblasts respond to EGF-induced cell migration but the response is somewhat diminished compared to normal adult fibroblasts (approximately 30% reduced); the mitogenic response was similarly blunted (approximately 5% reduced). Keloid fibroblasts express near normal levels of EGFR (82%), but show a much more attenuated activation of EGFR itself and the motility-associated phospholipase C-gamma. This was reflected in part by rapid loss of EGFR upon exposure to EGF. Interestingly, while extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK-MAPK) activation was relatively robust in keloid fibroblasts, the downstream triggering of the motility-associated calpain activity was blunted. This was reflected by high cell-substratum adhesiveness in the keloid fibroblasts. Thus, the blunted migratory response to EGF noted in keloid fibroblasts appears due to limited activation of two important biochemical switches for cell motility. 相似文献
3.
Psychological Disturbance and its Associations in the Children of the Gujarati Community 总被引:1,自引:1,他引:0
Latha Hackett Richard Hackett David C. Taylor 《Journal of child psychology and psychiatry, and allied disciplines》1991,32(5):851-856
The infrequent referral of Asian children to child psychiatry clinics was noted. By administering Rutter's scale A2 to samples of Gujarati and English parents with children between the ages of 4 and 7 years a lower rate of disturbance was demonstrated among the Asian sample providing an explanation for the original observation. Family and child-rearing factors associated with disturbance were identified. 相似文献
4.
D. Ashwath C. Latha M. B. Soudarssanane H. V. Wyatt 《Indian journal of pediatrics》1993,60(3):451-454
Adults accompanying 64 children attending a hospital out-patient clinic were questioned about treatment and injections given
for illnesses in the previous month. Half the children had received injections, almost all given by private doctors: we consider
most of these injections to have been unnecessary. Three girls were paralysed by aggravation poliomyelitis after unnecessary
injections. Adults approved of injections although they did not know what was injected. 相似文献
5.
The diagnostic cytomorphologic findings in a case of elastofibroma dorsi are described in this report. The correct diagnosis was initially overlooked on fine-needle aspiration, and was subsequently made by open biopsy. Review of the FNA material, however, demonstrated scanty but diagnostic material. Cytologic examination revealed a mixture of fibroblasts, adipose tissue, and swollen lightly staining cyanophilic elastic fibers in a background of collagenous matrix. Cross sections of the elastic fibers had the typical serrated and globular appearance. These fibers stained positive with elastin stains. The cytomorphology of elastofibroma dorsi with diagnostic pitfalls and differential diagnostic dilemmas are discussed in this article. © 1994 Wiley-Liss, Inc. 相似文献
6.
7.
William D. Stoll Robert A. Mester James N. Fleming Joel M. Sirianni Joseph A. Abro Edward D. Colhoun David J. Taber Latha Hebbar 《Transplantation proceedings》2021,53(5):1665-1669
BackgroundLiver transplantation is a complex surgical procedure. The experience of the anesthesiologist, and its potential relationship to patient morbidity and mortality, is yet to be determined. We sought to explore this possible association using our institutional training patterns as the subject of study.MethodsThis is a single center retrospective analysis investigating the association of an anesthesiologist's experience with liver transplantation and its potential effect on early patient outcomes in adult liver transplant recipients from January 2010 to September 2016. Training of team members consisted of a 6-month period of clinical shadowing with a senior anesthesiologist and co-staffing 8 liver transplant procedures before solo staffing a liver transplant. Specifically, patient outcomes for the first 5 transplants after this training were investigated.ResultsThe only independent risk factor for early death or early graft loss was the amount of packed red blood cells administered during transplantation. With respect to secondary outcomes, the amount of packed red blood cells and hospitalization at the time of transplant were associated with the number of days on a ventilator, length of intensive care unit stay, and overall hospital length of stay.ConclusionsThe results of this study conclude that the training model currently in place for our new team members has no negative impact on patient outcomes after liver transplantation. 相似文献
8.
Winston D Prakash Srinivas Marmamula Asha Latha Mettla Jill Keeffe Rohit C Khanna 《Indian journal of ophthalmology》2022,70(6):2131
Purpose:Addressing childhood vision impairment (VI) is one of the main goals of the World Health Organization’s (WHO) combating blindness strategies. The primary aim of this study was to estimate the prevalence of VI, causes, and its risk factors in school children in Krishna district, Andhra Pradesh, India.Methods:Children aged 4–15 years were screened in schools using the 6/12 Snellen optotype by trained community eye health workers, and those who failed the test and those reported or found to have obvious eye conditions were referred to primary (VC), secondary (SC), or tertiary (TC) care centre appropriately, where they underwent a complete eye examination including cycloplegic refraction and fundus examination.Results:A total of 56,988 children were screened, of whom 51.18% were boys. The mean age was 9.69 ± 3.26 years (4–15 years). Overall, 2,802/56,988 (4.92%) children were referred to a VC, of which 632/56,988 (1.11%) required referral to SC/TC. PVA of <6/12 was found in 1.72% (95% confidence interval [CI]: 1.61–1.83). The prevalence of refractive error (corrected and uncorrected) was 2.38% (95% CI: 2.26–2.51) and myopia was 2.17% (95% CI: 2.05–2.29). In multivariable analysis, older children, those in urban schools, private schools, and children with a disability had an increased risk of VI and myopia. Additionally, the risk of myopia was higher among girls than boys. Of those referred and reached SC/TC, 73.64% were due to avoidable causes.Conclusion:Childhood VI prevalence was 1.72% in this region. Uncorrected refractive error (URE) was the major cause of VI in children. Older age, schools in urban locations, private schools, and the presence of disability were associated with the risk of VI among children. 相似文献
9.
Longitudinal Andhra Pradesh Eye Disease Study: rationale,study design and research methodology 下载免费PDF全文
Rohit C Khanna MD Gudlavalleti VS Murthy MD Srinivas Marmamula PhD Asha Latha Mettla MSc Pyda Giridhar PhD Seema Banerjee BOpt Konegari Shekhar DOA Subhabrata Chakrabarti PhD Clare Gilbert FRCS Gullapalli N Rao MD Andhra Pradesh Eye Disease Study Group 《Clinical & experimental ophthalmology》2016,44(2):95-105
10.