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排序方式: 共有133条查询结果,搜索用时 265 毫秒
1.
Panagiota Lambrou Eleftherios Zervas Erasmia Oikonomidou Niki Papageorgiou Manos Alchanatis Mina Gaga 《Annals of allergy, asthma & immunology》2007,98(6):567-572
BACKGROUND: Asthma and rhinitis often coexist, and there is evidence to suggest that they have similar histopathologic features. OBJECTIVE: To examine whether the inflammatory infiltration in the nasal mucosa in rhinitis is affected by the presence of asthma and allergy. METHODS: Nasal mucosa biopsy samples were collected from 44 individuals: 18 with rhinitis and asthma (9 allergic and 9 nonallergic), 16 with rhinitis and no asthma (8 allergic and 8 nonallergic), and 10 nonallergic control subjects. The alkaline phosphatase-anti-alkaline phosphatase method was applied to 6-microm-thick cryostat sections using monoclonal antibodies against T cells (CD4 and CD8) and eosinophils (EG2). Slides were counted blindly, and results are expressed as cells per high-power field. RESULTS: Eosinophil counts were higher in the nasal mucosa of rhinitic patients vs controls. No differences in cellular infiltration were detected between rhinitic patients with and without asthma or between allergic and nonallergic patients. A trend toward higher CD4+ T-cell counts in the nasal mucosa of rhinitic patients was observed, whereas no differences were noted in CD8+ T-cell infiltration among the groups. CONCLUSION: Inflammatory infiltration, characterized by the presence of eosinophils and CD4+ T cells, was similar in the nasal mucosa in noninfectious rhinitis irrespective of the presence of asthma or the allergic status of the patient. 相似文献
2.
Chromosome studies of a case of erythroleukemia in a 57-year-old female patient were made from bone marrow aspirates using the fluorescent primary stain/counterstain methodology. The chromosome number ranged from 42 to 110. There was a high proportion of hypotetraploid cells and a few hypertetraploid and hypooctaploid ones. Structurally normal chromosomes varied in number from cell to cell, ranging from one to seven in the polyploid cells. A number of marker chromosomes were observed, some of which occurred repeatedly in two copies per hypotetraploid cell. The chromosomes involved in aberrations were tentatively identified as #3, #5, #7, #12, #13, #15, #16, #18, #19, and #21. In the abnormal chromosome #16, which was missing a normal short arm, a new kind of heterochromatin was demonstrated by sequential staining with DA-DAPI and DAPI-AMD, suggesting de novo amplification of an A-T-rich satellite DNA sequence. 相似文献
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Lambrou GI Papadimitriou L Chrousos GP Vlahopoulos SA 《Molecular and cellular endocrinology》2012,351(2):142-151
Twenty years ago a proteasome inhibitor was suggested as therapy for glucocorticoid-resistant multiple myeloma, a disease that involves terminally differentiated B cells. Since then, research has proven that it has utility on a number of tumors resistant to chemotherapy. Hematologic malignancy, however, often involves lesser differentiated cells, which have a high potential to modulate their intrinsic machinery and thereby activate alternative rescue pathways. A corresponding multiplicity of therapies is not always practical. One approach to conditions with heterogeneous physiology is to identify key biochemical mediators, thereby reducing the number of treatment targets. Results from several ongoing studies indicate convergence of genomically diverse signal pathways to a limited number of key downstream regulators of apoptosis. Convergence of pathways can be exploited to address the problem of genetic heterogeneity in acute leukemia: this would mean treating multiple molecular aberrations with fewer drugs and enhanced therapeutic benefit. 相似文献
6.
Safioleas M Misiakos EP Kakisis J Manti C Papachristodoulou A Lambrou P Tsinari KK Skalkeas G 《International surgery》2000,85(4):358-365
Hydatid disease may affect several organs in the human body and thus represents a major challenge for the general surgeon. The aim of this study was to analyze the multiple clinical presentations of hydatid disease and the surgical options according to the involved organ. The medical records of 272 adult patients operated on for hydatid disease in our department during the period 1970-1996 were retrospectively reviewed. The most commonly involved organ was the liver (204 patients; 75%), followed by the lung (42 patients; 15.4%) and the spleen (14 patients; 5.1%). In 12 patients, the cysts were located in uncommon sites: in the pancreas (4 patients; 1.5%), the gallbladder (2 patients; 0.74%), the kidney, the thyroid gland, the breast, the pericardium, the supraclavicular region and the thigh (1 patient in each case; 0.37%). Clinical symptomatology varied according to anatomic location and pre-operative diagnosis was accomplished with plain abdominal films, ultrasound, computerized tomography and serological tests. The surgical procedures performed included simple closure with drainage, unroofing of the cyst with omentoplasty (for liver cysts), marsupialization, cyst excision, excision of the involved organ or combinations of procedures. Postoperative morbidity was mainly due to septic complications (n = 41), postoperative bleeding (n = 2), deep vein thrombosis (n = 2) and fistulae (n = 13). Four patients died in the early postoperative period (mortality rate, 1.5%) secondary to septic complications (n = 3) and pulmonary embolism (n = 1). During long-term follow-up, 14 patients developed recurrent disease. In conclusion, hydatid disease should be included in the differential diagnosis of cystic masses in solid organs or other anatomic sites, especially in endemic countries. Since there is not an effective medical treatment, surgery still remains the treatment of choice, offering a good clinical result and an acceptable recurrence rate. 相似文献
7.
The effect of contrast and luminance on mfERG responses in a monkey model of glaucoma 总被引:10,自引:0,他引:10
Raz D Seeliger MW Geva AB Percicot CL Lambrou GN Ofri R 《Investigative ophthalmology & visual science》2002,43(6):2027-2035
PURPOSE: To evaluate the effect of contrast and luminance attenuation on the multifocal electroretinogram (mfERG) responses of normal and glaucomatous eyes of cynomolgus monkeys. METHODS: Nine adult male cynomolgus monkeys with unilateral experimentally induced glaucoma were used. Hypertension-induced damage was confirmed by tomography of the optic disc. mfERGs were recorded with five different stimulus contrasts and/or luminance settings. The first-order and the first slice of second-order responses were analyzed. RESULTS: Waveforms of normal and glaucomatous eyes differed in shape and amplitude. Second-order responses contributed to first-order responses of the signals in the normal eyes, but made a negligible contribution to the signals in the glaucomatous eyes. Contrast and luminance attenuation affected both first- and second-order responses. The differences between signals in normal and glaucomatous eyes were sufficiently large for an unsupervised clustering algorithm to achieve accurate segregation. CONCLUSIONS: The observations in this study indicate that outer and inner retinal generators participate in first-order mfERG responses and that both inner and outer retinal contributors respond to contrast and luminance changes in stimulus. The hypertension-induced changes in the mfERG furthermore suggest damage to both inner and outer retina. 相似文献
8.
Barbetseas J Vyssoulis G Lambrou S Voussouras P Marinakis N Toutouzas P 《Cardiology in review》2002,10(4):214-217
The authors report on the case of a patient with infective endocarditis of a prosthetic valve in the aortic position, after receiving percutaneous transluminal coronary angioplasty. Transesophageal echocardiography provided valuable information about the existence and size of vegetations at the time of initial diagnosis and during followup. Despite successful treatment resulting in good control of the infection and a significant reduction of vegetation size, the patient still suffered a major cerebral embolic event early after hospital discharge. 相似文献
9.
Anatomy of pelvic arteries adjacent to the sacrospinous ligament: importance of the coccygeal branch of the inferior gluteal artery 总被引:15,自引:0,他引:15
Thompson JR Gibb JS Genadry R Burrows L Lambrou N Buller JL 《Obstetrics and gynecology》1999,93(6):973-977
OBJECTIVE: To examine the risk factors and pregnancy outcomes associated with 53 cases of amniotic fluid embolism that occurred in California during the 2-year period January 1, 1994 to December 31, 1995. METHODS: Data were obtained from a computerized database that contains linked records from the vital statistics birth certificate and hospital discharge summaries of both mother and newborn. This database covered all singleton deliveries that occurred in 328 civilian acute-care hospitals in California, which represented 98% of all deliveries in California. All cases of amniotic fluid embolism were examined for other pregnancy complications. RESULTS: There were 1,094,248 deliveries during that 2-year period. Fifty-three singleton gestations had the diagnosis of amniotic fluid embolism, for a population frequency of one per 20,646 deliveries. Fourteen women with amniotic fluid embolism died, for a maternal mortality rate of 26.4%. There were 35 (66%) diagnoses of disseminated intravascular coagulation (DIC), 38 (72%) diagnoses of hemorrhage, and 25 (47%) diagnoses of obstetric shock. Among the 14 women who died, the frequency of DIC (79%) and hemorrhage (71%) was not different compared with that of the survivors (62% and 72%, respectively), but obstetric shock was higher (86%, P = .02) than in survivors (33%). The average maternal length of stay for survivors was 6.5 days (range 3-27 days, median 5 days). The cesarean rate was 60% and the frequency of fetal distress was 49%. CONCLUSION: In this population-based study of reported cases of amniotic fluid embolism, the maternal mortality rate (26.4%) was significantly less than previously reported and might reflect a more accurate population frequency. In addition, patients who survived and patients who died had similar pregnancy complications, suggesting that amniotic fluid embolism was present in all cases and not limited to those who died. 相似文献
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