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排序方式: 共有61条查询结果,搜索用时 31 毫秒
1.
Benoit Mesnard Maxime Leroy James Hunter Delphine Kervella Marc-Olivier Timsit Lionel Badet Pascal Glemain Emmanuel Morelon Fanny Buron Moglie Le Quintrec-Donnette Vincent Pernin Marc Ladriere Sophie Girerd Christophe Legendre Antoine Sicard Laeticia Albano Stephane De Vergie Clarisse Kerleau Thomas Prudhomme Jérôme Rigaud Diego Cantarovich Gilles Blancho Georges Karam Magali Giral Simon Ville Julien Branchereau For the Données Informatisées et VAlidées en Transplantation/Computerized VAlidated Data in Transplantation Consortium Affiliations† 《BJU international》2022,129(2):225-233
2.
Aulo Gelli Anissa Collishaw Josue Awonon Elodie Becquey Ampa Diatta Loty Diop Rasmane Ganaba Derek Headey Alain Hien Francis Ngure Abdoulaye Pedehombga Marco Santacroce Laeticia C. Toe Hans Verhoef Harold Alderman Marie T. Ruel 《Maternal & child nutrition》2023,19(4):e13528
Nutrition-sensitive agriculture programmes have the potential to improve child nutrition outcomes, but livestock intensification may pose risks related to water, sanitation and hygiene (WASH) conditions. We assessed the impact of SELEVER, a nutrition- and gender-sensitive poultry intervention, with and without added WASH focus, on hygiene practices, morbidity and anthropometric indices of nutrition in children aged 2−4 years in Burkina Faso. A 3-year cluster randomised controlled trial was implemented in 120 villages in 60 communes (districts) supported by the SELEVER project. Communes were randomly assigned using restricted randomisation to one of three groups: (1) SELEVER intervention (n = 446 households); (2) SELEVER plus WASH intervention (n = 432 households); and (3) control without intervention (n = 899 households). The study population included women aged 15−49 years with an index child aged 2−4 years. We assessed the effects 1.5-years (WASH substudy) and 3-years (endline) post-intervention on child morbidity and child anthropometry secondary trial outcomes using mixed effects regression models. Participation in intervention activities was low in the SELEVER groups, ranging from 25% at 1.5 years and 10% at endline. At endline, households in the SELEVER groups had higher caregiver knowledge of WASH-livestock risks (∆ = 0.10, 95% confidence interval [CI] [0.04−0.16]) and were more likely to keep children separated from poultry (∆ = 0.09, 95% CI [0.03−0.15]) than in the control group. No differences were found for other hygiene practices, child morbidity symptoms or anthropometry indicators. Integrating livestock WASH interventions alongside poultry and nutrition interventions can increase knowledge of livestock-related risks and improve livestock-hygiene-related practices, yet may not be sufficient to improve the morbidity and nutritional status of young children. 相似文献
3.
Fiona Bartoli Marjolaine Debant Eulashini Chuntharpursat-Bon Elizabeth L. Evans Katie E. Musialowski Gregory Parsonage Lara C. Morley T. Simon Futers Piruthivi Sukumar T. Scott Bowen Mark T. Kearney Laeticia Lichtenstein Lee D. Roberts David J. Beech 《The Journal of clinical investigation》2022,132(5)
Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the control of capillary density. Conditional endothelial cell–specific deletion of Piezo1 in adult mice depressed physical performance. Muscle microvascular endothelial cell apoptosis and capillary rarefaction were evident and sufficient to account for the effect on performance. There was selective upregulation of thrombospondin-2 (TSP2), an inducer of endothelial cell apoptosis, with no effect on TSP1, a related important player in muscle physiology. TSP2 was poorly expressed in muscle endothelial cells but robustly expressed in muscle pericytes, in which nitric oxide (NO) repressed the Tsp2 gene without an effect on Tsp1. In endothelial cells, Piezo1 was required for normal expression of endothelial NO synthase. The data suggest an endothelial cell–pericyte partnership of muscle in which endothelial Piezo1 senses blood flow to sustain capillary density and thereby maintain physical capability. 相似文献
4.
Pierre Vantourout Claudia Radojkovic Laeticia Lichtenstein Véronique Pons Eric Champagne Laurent O Martinez 《World journal of gastroenterology : WJG》2010,(47)
Mitochondrial ATP synthase has been recently detected at the surface of different cell types, where it is a high affinity receptor for apoA-I, the major protein component in high density lipoproteins (HDL). Cell surface ATP synthase (namely ecto-F1-ATPase) expression is related to different biological effects, such as regulation of HDL uptake by hepatocytes, endothelial cell proliferation or antitumor activity of Vγ9/Vδ2 T lymphocytes. This paper reviews the recently discovered functions and regulations of ... 相似文献
5.
This article reviews past and current strategies of the use of bone graft substitutes along with the future biologic alternatives that can enhance the functional capabilities of those grafts. Many of these bone graft substitute alternatives include ceramic-based, allograft-based, factor-based and polymer-based whereas others are cell-based. The ways of achieving the goal of tissue engineering using stem cells and their lineage to regenerate tissue have been detailed with regard to both the generation of sufficient vascular invasion of the tissue to improve oxygen and nutrient supply, and the development of innovative physical/chemical stimuli to induce bone formation with the proper biomaterial to carry the cells. It is imperative to integrate basic polymer science with molecular biology and stem cell biology, in the design of new materials that perform very sophisticated signaling needed for integration and function. 相似文献
6.
7.
Leslie Jones Brenda de Kok Katie Moore Saskia de Pee Juliet Bedford Katrien Vanslambrouck Laeticia Celine Toe Carl Lachat Nathalie De Cock Moctar Oudraogo Rasman Ganaba Patrick Kolsteren Sheila Isanaka 《Maternal & child nutrition》2021,17(1)
Poor maternal nutrition contributes to poor birth outcomes, including low birth weight and small for gestational age births. Fortified balanced energy protein (BEP) supplements may be beneficial, although evidence is limited. This mixed method study, conducted among pregnant women in Burkina Faso, is part of a larger clinical trial that seeks to understand the impact of fortified BEP supplements on pregnancy outcomes and child growth. The formative research reported here, a single‐meal rapid assessment of 12 product formulations, sought to understand product preferences for provision of BEP supplements and contextual factors that might affect product acceptability and use. Results indicate a preference for products perceived as sweet rather than salty/savoury and for products perceived as familiar, as well as a sensitivity to product odours. Women expressed a willingness and intention to use the products even if they did not like them, because of the health benefits for their babies. Data also indicate that household food sharing practices may impact supplement use, although most women denied any intention to share the products. Sharing behaviour should therefore be monitored, and strategies to avoid sharing should be developed during the succeeding parts of the research. 相似文献
8.
François Lefrère Laeticia Mauge Delphine Réa Jean‐Antoine Ribeil Liliane Dal Cortivo Anne C. Brignier Charbel Aoun Jérôme Larghéro Marina Cavazzana‐Calvo Jean‐Michel Micléa 《Transfusion》2013,53(3):564-569
BACKGROUND: This report describes the specific kinetics of the peripheral blood (PB) CD34+ cell concentration in a selected group of very poor stem cell mobilizer patients treated with granulocyte–colony‐stimulating factor (G‐CSF) and plerixafor and determines the kinetics' impact on apheresis. STUDY DESIGN AND METHODS: All patients had previously experienced at least two failures of mobilization (without use of plerixafor). The present salvage therapy consisted in the administration of 10 µg/kg/day G‐CSF for 5 days added to a dose of plerixafor administered at between 5 a.m. and 6 a.m. on Day 5. The PB CD34+ cell counts were tested every 3 hours thereafter. Apheresis was initiated as soon as the PB CD34+ cell count reached 10 × 106/L. RESULTS: A PB CD34+ cell count higher than 10 × 106/L was observed as soon as 3 hours after plerixafor administration in 10 of the 11 patients who reached this threshold at some point in the monitoring process. Interestingly, all patients presented an early decrease in the PB CD34+ cell count 8 to 12 hours after plerixafor administration (below 10 × 106/L for seven patients). CONCLUSION: Had such patients been tested for PB CD34+ cell mobilization according to conventional criteria (i.e., 11 hr after plerixafor administration), apheresis would not have been performed at the optimal timing. For very poor stem cell mobilizer patients, early monitoring of PB CD34+ cell count may be required for the optimal initiation of apheresis. 相似文献
9.
Karel Veselský Vilma Lahti Laeticia Petit Vclav Prajzler Jan ulc Helena Jelínkov 《Materials》2021,14(14)
The influence of the addition of Y2O3 on the structural, spectroscopic, and laser properties of newly prepared Er, Yb-doped strontium-sodium phosphate glass was investigated. While the addition of Y2O3 has a small influence on the absorption spectra and fluorescence lifetime, it has a strong impact on the emission cross-section and on OH− content. The glasses were used as the active medium for diode-pumped laser emitting at 1556 nm. The increase in Y2O3 content leads to a significant 35% increase in laser slope efficiency up to 10.4%, but at the expense of the substantial reduction of the wavelength tunability from 82 to 54 nm. 相似文献
10.
This longitudinal study investigates the effects of different long-term dietary treatments on spatial memory in rats. An ad libitum group, a group of rats fasting two days a week, and a group fed 70% of the ad libitum food intake were studied at 6, 12, 19 and 24 months of age. Spatial memory was tested in the Morris water maze. Three test situations were presented: a spatial learning test, a retrieval test, and a reversal test. In the first test, the animals had to find a submerged platform which remained in a fixed location throughout the study. Dietary treatment of rats had no effect on the performances at any of the ages tested. In the retrieval test, rats had to search for the location of the trained platform which had been removed for two minutes. All three groups searched at the correct location at 12 months of age. However, at 19 and 24 months of age, the ad libitum and fasting groups showed a significant deterioration in performance. This was not the case for the 70% restricted rats. In the reversal test, the platform which had been at the same location for the spatial learning test was moved into the opposite quadrant. The 70% restricted 24 month old rats adapted to the new situation by rapidly changing their swimming pattern. Again this was not the case for the two other groups. In conclusion, our study shows that food restriction is beneficial to old rats tested throughout their life in the Morris water maze, especially in the retrieval and reversal tests. Our study also indicates that food restriction and fasting do not have the same effect on the spatial memory in the old rats although this needs to be substantiated with further inquiries. 相似文献