Synthesis and antiviral activity of 2-[α-nitro-β-aminovinyl]-hydroquinone and -p-benzoquinone

Translated from Khimiko-farmatsevitcheskii Zhurnal, Vol. 25, No. 4, pp. 35–37, April, 1991.     

Synthesis and antiinflammatory activity of N-[1-(5-R-Oxy-2-methylbenzofuran-3-yl)ethyl]-N-hydroxyureas

Two benzofuran derivatives — analogs of 5-lipoxygenase antagonist zileuton — have been synthesized and tested. It is established that both compounds possess antiinflammatory activity. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 17–20, December, 2005.     

Possibilities and limitations of predicting bioavailability of combination drugs using one of the components

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 29, No. 4, pp. 18–21, April, 1995.     

Synthesis and pharmacological activity of derivatives of 3-aminomethylenindolin-2-one

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 28, No. 4, pp. 22–26, April, 1994.     

Acute coronary syndromes

The first 150 words of the full text of this article appear below. Key points Coronary artery disease accounts for >30% ofdeaths in Western society. The diagnosis of myocardial infarctionshould be qualified by size, causation and time from occurrence. Mortalityis reduced by immediate or ‘primary’ percutaneouscoronary intervention or thrombolysis within the first 24 hof onset of ST-segment elevation myocardial infarction. Strategiesto reduce platelet activation (glycoprotein IIb/IIIa receptorantagonists, or clopidogrel) are now recommended in the treatmentof high-risk non-ST-segment myocardial infarction/unstable angina. Elevatedserum troponins may be the result of non-ischaemic myocardialdamage, especially in critical illness.