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排序方式: 共有245条查询结果,搜索用时 15 毫秒
1.
LEON FLICKER 《Internal medicine journal》1989,19(4):400-406
With the growing advent of rehabilitation units designed particularly for the needs of the stroke patient, a need has arisen for the evaluation of these units. In particular, several questions have to be asked 相似文献
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Inhibition of 3,3',4,4',5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2',4,4',5,5'-Hexachlorobiphenyl 总被引:1,自引:0,他引:1
ZHAO FENG; MAYURA KITTANE; KOCUREK NATHAN; EDWARDS JOHN F.; KUBENA LEON F.; SAFE STEPHEN H.; PHILLIPS TIMOTHY D. 《Toxicological sciences》1997,35(1):1-8
3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose-dependentinduction of chicken embryolethality, malformations, edema,and liver lesions at doses ranging from 0.5 to 12.0 µg/kg.In contrast, no embryotoxicity was observed after treatmentwith 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreatedwith 2.0 µ/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protectionfrom 3,3',4,4',5-pentaCB-induced embryo malformations, edema,and liver lesions, whereas no inhibition of embryolethalitywas observed. These results further extend the response-specificnonadditive interactions of binary mixtures of polychlorinatedbiphenyls (PCBs) and should be considered in the developmentof approaches for hazard assessment of PCB mixtures and relatedcompounds. 相似文献
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LEVIER DAVID G.; MCCAY J. ANN; STERN MALVIN L.; HARRIS LOUIS S.; PAGE DENNIS; BROWN RONNETTA D.; MUSGROVE DEBORAH L.; BUTTERWORTH LEON F.; WHITE KIMBER L. JR.; MUNSON ALBERT E. 《Toxicological sciences》1994,22(4):525-542
This study was undertaken to investigate a number of immuneparameters which may be compromised with exposure to morphinesulfate. Mice were implanted subcutaneously with 8-, 25-, or75-mg morphine sulfate pellets. Placebo pellets of identicalmakeup to the 75-mg morphine pellet (without morphine of course)were used as a control. Twenty-four hours after implantationof a 75-mg morphine pellet, blood levels reached a peak of 1610ng/ml. Corticosterone increased in parallel with morphine andreached a peak level of 966 ng/ml 24 hr after implantation.The dose response of morphine to increase corticosterone, however,was fiat. The weight of the lymphoid organs, spleen and thymus,and the liver were significantly reduced in the morphine-treatedgroups. Morphine treatment was associated with an increase inserum albumin, SGPT, BUN, and alkaline phosphatase indicativeof hepatic damage. In contrast to increased serum proteins,the C3 component of complement was reduced in a dose-dependentmanner. Leukocyte number in the peripheral blood was significantlyreduced, while erythro-cyte number and hematocrit were bothincreased. The number of B cells and T cells was decreased inmorphine-treated animals. However, the percentage of T cellsrelative to B cells was increased. The primary IgM antibodyresponse to the T-depen-dent antigen, sheep red blood cells,was decreased. Natural killer cell activity was reduced in responseto morphine, as was the phagocytic capacity of Kupffer cells.Host-resistance models of Listeria monocytogenes or Streptococcuspneumoniae showed an increased resistance following administrationof morphine. This increased host resistance, however, was notdue to an increase in antimicrobial action of sera obtainedfrom mice treated with morphine. The majority of morphine'seffects on the immune system exhibited a flat dose response,suggesting that these effects may be mediated secondarily throughcorticosterone. 相似文献
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APPELS A.; KOP W.; BAR F.; DE SWART H.; DE LEON C. MENDES 《European heart journal》1995,16(1):1880-1885
It has been observed that vital exhaustion, a state characterizedby unusual tiredness, increased irritability and feelings ofdemoralization not uncommonly precedes myocardial infarctionin apparently healthy individuals. This observation raised thequestion as to whether vital exhaustion is a marker of subclinicalcoronary disease. To answer that question the condition wasassessed in 105 male patients (mean age 54·8 year) beforeand 2 weeks after successful percutaneous transluminal coronaryangioplasty (PTCA) by the Maastricht questionnaire. Vital exhaustionwas found to be significantly correlated with the number ofdiseased vessels before PTCA and to decrease significantly afterPTCA. However, the association was rather modest (R2=0·08)and most patients remained exhausted after PTCA. During a follow-upperiod of 1·5 years, 32 patients (30%) experienced anew cardiac event (cardiac death, myocardial infarction, coronaryartery bypass grafting, repeat PTCA, a new coronary lesion orrecurrent angina with documented ischaemia). Univariate andmultivariate analyses showed that the number of diseased vessels,hypercholesterolaemia, and vital exhaustion were independentlyassociated with future events. The odds ratios were 3·74(P=0·02), 3·08 (P=0·08) and 3·07(P=0·04), respectively. It is concluded that the tirednesspreceding a cardiac event is only modestly associated with theextent of coronary artery disease and that a state of exhaustionafter PTCA increases the risk for a new cardiac event. 相似文献
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MOSHE RAV ACHA M.D. Ph.D. JOHN J. KEANEY M.B. B.A.O. B.Ch. STEVEN A. LUBITZ M.D. M.P.H. DAVID J. MILAN M.D. MOUSSA MANSOUR M.D. KEVIN E. HEIST M.D. Ph.D. LEON M. PTASZEK M.D. Ph.D. JAGMEET P. SINGH M.D. Ph.D. DAN BLENDEA M.D. Ph.D. THEOFANIE MELA M.D. 《Pacing and clinical electrophysiology : PACE》2015,38(3):334-342
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Alterations in the vascular sinus and hematopoietic compartment of rat bonemarrow were observed with electronmicroscopy during the pathogenesis of anacute myelogenous leukemia. As the disease progresses, the sinus wall becomesdamaged and disintegrates; normal hemicelements disappear, and the marrow compartment becomes packed with leukemicmyeloblasts. Viruslike particles are present in intercellular spaces and appear tobud from leukemic cells. Submitted on December 14, 1970 Revised on April 29, 1971 Accepted on July 16, 1971 相似文献
10.
Steroid Hormone Metabolism in Chronic Myelogenous Leukemia 总被引:1,自引:0,他引:1
Individual metabolites of steroid hormones were isolated and measuredfrom the urine of patients with chronic myelogenous leukemia. The resultswere compared with earlier studies of patients with chronic lymphatic leukemia, men with prostatic cancer, women with breast cancer and normalmen and women. The metabolites of hydrocortisone were in the normal rangefor the patients with chronic myelogenous leukemia but the amount of tetrahydrocortisol was generally greater than that of tetrahydrocortisone. Therewas no evidence for a sex difference in the production of these metabolites.The tentative conclusion was drawn that metabolites of the "adrenal androgens" were also in the normal range in chronic myelogenous leukemia. Theseresults contrast with those in chronic lymphatic leukemia patients where asex difference in production of hydrocortisone was evident and the metabolitesof "adrenal androgens" were at low levels in both sexes. Submitted on August 13, 1964 Accepted on September 20, 1964 相似文献