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GHADA BEAINO BABAK KHOSHNOOD MONIQUE KAMINSKI VÉRONIQUE PIERRAT STÉPHANE MARRET JACQUELINE MATIS BERNARD LEDÉSERT GÉRARD THIRIEZ JEANNE FRESSON JEAN‐CHRISTOPHE ROZÉ VÉRONIQUE ZUPAN‐SIMUNEK CATHERINE ARNAUD ANTOINE BURGUET BÉATRICE LARROQUE GÉRARD BRÉART PIERRE‐YVES ANCEL for the EPIPAGE Study Group 《Developmental medicine and child neurology》2010,52(6):e119-e125
Aim The aim of this study was to assess the independent role of cerebral lesions on ultrasound scan, and several other neonatal and obstetric factors, as potential predictors of cerebral palsy (CP) in a large population‐based cohort of very preterm infants. Method As part of EPIPAGE, a population‐based prospective cohort study, perinatal data and outcome at 5 years of age were recorded for 1812 infants born before 33 weeks of gestation in nine regions of France in 1997. Results The study group comprised 942 males (52%) and 870 females with a mean gestational age of 30 weeks (SD 2wks; range 24–32wks) and a mean birthweight of 1367g (SD 393g; range 450–2645g). CP was diagnosed at 5 years of age in 159 infants (prevalence 9%; 95% confidence interval [CI] 7–10%), 97 males and 62 females, with a mean gestational age of 29 weeks (SD 2wks; range 24–32wks) and a mean birthweight of 1305g (SD 386g; range 500–2480g). Among this group, 67% walked without aid, 14% walked with aid, and 19% were unable to walk. Spastic, ataxic, and dyskinetic CP accounted for 89%, 7%, and 4% of cases respectively. The prevalence of CP was 61% among infants with cystic periventricular leukomalacia, 50% in infants with intraparenchymal haemorrhage, 8% in infants with grade I intraventricular haemorrhage, and 4% in infants without a detectable cerebral lesion. After controlling for cerebral lesions and obstetric and neonatal factors, only male sex (odds ratio [OR] 1.52; 95% CI 1.03–2.25) and preterm premature rupture of membranes or preterm labour (OR 1.72; 95% CI 0.95–3.14) were predictors of the development of CP in very preterm infants. Interpretation Cerebral lesions were the most important predictor of CP in very preterm infants. In addition, infant sex and preterm premature rupture of membranes or preterm labour were also independent predictors of CP. 相似文献
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SEBASTIAN STEC M.D. Ph.D. JANUSZ ŚLEDŹ M.D. MARIUSZ MAZIJ M.D. MAŁGORZATA RAŚ M.D. BARTOSZ LUDWIK M.D. MICHAŁ CHRABĄSZCZ B.S. R.N. ARKADIUSZ ŚLEDŹ B.S. MAŁGORZATA BANASIK R.N. MAGDALENA BZYMEK R.N. KRZYSZTOF MŁYNARCZYK M.D. KAROL DEUTSCH M.St. MICHAŁ LABUS M.D. JERZY ŚPIKOWSKI M.D. LESŁAW SZYDŁOWSKI M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2014,25(8):866-874
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FRITS ABILDGAARD JENS J. LED PER BALSCHMIDT FINN B. HANSEN 《Chemical biology & drug design》1989,34(4):340-345
Detailed and precise information on the exchanges in water of the peptide hydrogens of the insulin fragment B23-B29 (Gly23-Phe24-Phe25-Tyr26-Th27-Pro28-Lys29) has been obtained from magnetization-transfer measurements, and nonlinear least-squares fits of the experimental spectra using the expression for the discrete Fourier transform of a sum of exponentially damped sinusoids. From a comparison of the differential exchange rates with those expected for completely solvent-exposed peptide hydrogens, specific conformational features of the heptapeptide are suggested. 相似文献
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