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排序方式: 共有264条查询结果,搜索用时 31 毫秒
1.
S Ogoshi M Iwasa S Kitagawa Y Ohmori S Mizobuchi Y Iwasa T Tamiya 《JPEN. Journal of parenteral and enteral nutrition》1988,12(1):53-57
The effect of a nucleoside-nucleotide mixture on liver injury of rats induced by D-galactosamine was studied by examining changes in function and histopathology of the liver. Animals with liver damage received total parenteral nutrition with glucose and amino acids supplemented with a nucleoside-nucleotide mixture containing inosine, cytidine, GMP, uridine and thymidine, or with uridine which inhibits galactosamine injury, or with liver cell extract containing flavin adenine dinucleotide and nucleic acid derivatives. As control, animals with liver damage received total parenteral nutrition with glucose and amino acids only. The serum GOT and GPT concentrations were significantly lower in the group supplemented with nucleoside-nucleotide mixture than those in other groups. A large dose (1.2 g/kg) of uridine inhibited liver injury, but a lower dose (0.14 g/kg) did not have any effect, whereas nucleoside-nucleotide mixture containing the same amount of uridine inhibited the injury. Liver cell extract also did not improve liver function. Thus infusion of a physiological and balanced mixture of nucleosides or nucleotides may improve liver function in rats with liver injury. 相似文献
2.
Determination of the prognostic significance of cyclin B1 overexpression in patients with esophageal squamous cell carcinoma 总被引:2,自引:0,他引:2
Murakami H Furihata M Ohtsuki Y Ogoshi S 《Virchows Archiv : an international journal of pathology》1999,434(2):153-158
Recent studies have identified a family of proteins referred to as cyclins, which control the cell cycle. Cyclin B1 activates
cdc2, which regulates cell progression through the G2 and M phases. The main aim of this study was to examine the relationships
between the cyclin B1 expression in human esophageal squamous cell carcinoma (SCC) and clinicopathological factors and prognosis
of the patients. Eighty-seven cases of primary human SCC consecutively obtained at esophagectomy were immunohistochemically
studied using an anti-human cyclin B1 protein antibody (2H1-H6). The relationship between cyclin B1 expression and clinicopathological
factors, including prognosis, were also statistically assessed. Positive immunostaining of cancer cells, mainly in the cytoplasm,
was detected in 72.4% (63/87): heterogeneous pattern in 37.9 % (33/87) and homogeneous pattern in 34.5% (30/87). The prevalence
of cyclin B1 expression was significantly higher in cases with invasion deeper than the muscularis propria (P<0.005) and with venous invasion (P<0.01) than in other cases. Patients whose SCCs expressed high levels of cyclin B1 protein had a significantly poorer prognosis
than did the other patients (P<0.05). Multivariate analysis demonstrated that cyclin B1 status was an important factor affecting survival (P<0.05). These findings demonstrated that overexpression of cyclin B1 protein is associated with tumor behavior and prognosis
for patients with human esophageal SCC.
Received: 25 June 1998 / Accepted: 21 October 1998 相似文献
3.
Kyogi Ogoshi Tomoo Tajima Toshio Mitomi Kimiyoshi Tsuji 《Clinical & experimental metastasis》1996,14(3):277-281
We investigated the association between human leucocyte antigen (HLA) antigens and lymph node metastasis in 724 gastric cancer patients. Among patients who had poorly differentiated adenocarcinoma with or without HLA-DR4 antigen, lymph node metastasis was detected in 80.8 and 54.9%, respectively (relative risk (RR)=3.5, P = 0.0005, corrected P = 0.0285). It was more common in patients with a family history of cancer death (RR = 7.7). Among signet ring cell carcinoma patients with or without HLA-1152 antigen, lymph node metastasis was detected in 57.7 and 19.7%, respectively (RR =5.6, P=0.0001, corrected P=0.0086). It was more common in patients who were smokers (RR = 8.3). Our findings suggest that HLA-DR4 and HLA-1152 antigens are associated with lymph node metastasis in gastric cancer. 相似文献
4.
Tsuji K Ogoshi K Shimura T Hagihara M Isono K Kimura K Nagamachi Y Kashiwagi N 《International journal of oncology》1996,9(1):73-78
In order to clarify the immunogenetical background, host factors in oncology, human leukocyte antigen (HLA) and tumor necrosis factor (TNF) beta alleles as prognostic, preventive and therapeutic indicators were investigated in 712 patients with a histologic diagnosis of adenocarcinoma of the stomach treated with gastrectomy. HLA and TNF beta alleles were tested serologically and by DNA-PCR typing. The absence of HLA Cw1 antigen may represent resistant and prognostic factors. HLA-B51, B61 and TNF beta 10.5 kb homozygote alleles are therapeutic, survival and prognostic factors. Considering the relation with lymph node metastasis, HLA-DR4 antigen and HLA-DRB 1*0405 allele were found to be risk factors for lymph node metastasis in poorly differentiated adenocarcinoma. TNF beta 10.5 kb homozygote allele also represented a risk factor for lymph node metastasis. TNF beta 5.5 kb homozygote allele was considered a resistant factor for lymph node metastasis in poorly differentiated adenocarcinoma. HLA and TNF beta alleles can play an important role as prognostic, preventive and therapeutic indicators in gastric cancer. Therefore, TNMH (TNM with host factor) should be proposed as a new approach. 相似文献
5.
Pure red cell aplasia and myasthenia gravis with thymoma: a case report and review of the literature 总被引:3,自引:0,他引:3
Mizobuchi S; Yamashiro T; Nonami Y; Yamamoto A; Kume M; Nakaya H; Sawada T; Taguchi H; Moriki T; Ogoshi S 《Japanese journal of clinical oncology》1998,28(11):696-701
A case of pure red cell aplasia (PRCA), myasthenia gravis (MG) and thymoma
is reported. A 70-year-old woman presented with severe anemia. She had been
diagnosed as having MG 8 years earlier and her symptoms were adequately
controlled with ambenonium chloride. When she visited our hospital, her
hematocrit was 13.7% with a hemoglobin concentration of 4.7 g/dl and her
reticulocyte counts were persistently abnormal at 0.1%. Although both
direct and indirect Coombs' tests were positive, there was no evidence of
hemolysis. Routine screening tests for other etiologies of anemia were
negative. Serological tests for anti-DNA and anti-acetylcholine receptor
antibodies gave positive results. A bone marrow examination revealed severe
erythroid hypoplasia. PRCA was diagnosed and the patient was treated with
periodic transfusions. A lateral view chest roentgenogram and a computed
tomography scan of the thorax showed the presence of an anterior
mediastinal mass which was suspected to be thymoma. The patient underwent
thymothymectomy and the tumor was diagnosed as a thymoma. Although the
patient received no treatment for MG and PRCA after surgery, her
hematological test results rapidly improved and she was discharged from the
hospital on the 29th postoperative day. At that time, her hematocrit was
33.2%, her hemoglobin concentration was 10.0 g/dl, her peripheral
reticulocyte level was 1.8% and her left partial ptosis had improved. She
is doing well, 9 months after surgery. For a patient to remain in remission
without treatment for PRCA and MG after thymothymectomy is extremely rare.
相似文献
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8.
Alice Ramyil Patricia Wade Chris Ogoshi Musa Goyol Olukorede Adenuga Nantok Dami 《Ophthalmic epidemiology》2015,22(3):184-189
ABSTRACTPurpose: To determine the magnitude of trachoma and the prevalent forms of the disease, and to provide baseline data for the establishment of a trachoma control program in Jigawa State, northwestern Nigeria.Methods: A population-based cross-sectional survey was conducted in Jigawa State in May 2007 using a 2-stage cluster random sampling technique to select 4598 persons from 40 villages based on probability proportional to size. All participants were examined using a penlight and a 2.5?×?binocular loupe for signs of trachoma, and graded using the World Health Organization (WHO) simplified grading system.Results: A total of 4598 people were seen with 99.96% coverage. Of these, 2460 (53.5%) were female and 2138 (46.5%) were male. Mean age was 21.6 years (?±?19.8 years). The prevalence of follicular trachoma in children aged ≤9 years was 20.5% (95% confidence interval, CI, 18.7–22.4%) with no difference between the sexes. The prevalence of trichiasis in adults aged ≥15 years was 5%, and the prevalence was higher in females than males (odds ratio 2.60, 95% CI 2.06–3.28; p?<?0.001).Conclusion: Trachoma is a major problem in Jigawa State; there is a need to train trichiasis surgeons and empower them to carry out community-based surgery. District-level prevalence of trachoma needs to be determined to know which aspects of the WHO SAFE strategy (surgery, antibiotics, facial cleanliness and environmental improvements) need to be emphasized in each district. 相似文献
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