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排序方式: 共有382条查询结果,搜索用时 15 毫秒
1.
K. S. Us P. M. Klodt V. S. Kudrin A. Ya. Sapronova R. U. Ostrovskaya M. V. Ugryumov K. S. Rayevsky 《Neurochemical Journal》2007,1(2):138-142
The level of spontaneous and K+-stimulated release of endogenous glutamate was studied in experiments on slices of brain cortex of Wistar rats. Pronounced spontaneous release of the neuromediator and its increase under conditions of stimulation were registered by high-performance liquid chromatography with electrochemical detection. The effect of the nootropic and neuroprotective dipeptide Noopept (GVS-111) on release of glutamate was investigated. The peptide in concentrations of 10?5 and 10?6 M caused a statistically significant decrease in spontaneous and K+-stimulated glutamate release. This effect could be the basis of the neuroprotective action of the peptide, suggesting that further studies of Noopept as neuroprotector are very promising. 相似文献
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Classical and anaplastic seminoma: difference in survival 总被引:1,自引:0,他引:1
Classical and anaplastic seminoma are traditionally treated with radiation therapy and are said to have the same prognosis. A retrospective study was undertaken of 90 seminoma patients treated with radiation therapy between 1961 and 1985. The classical group consisted of 71 patients of whom 50 had stage I and 21 had stage II disease. The anaplastic group consisted of 19 patients of whom ten had stage I and nine had stage II disease. The median follow-up time was 64 months for the entire group. The 10-year relapse-free survival rate for the classical group was 94% and for the anaplastic group was 70% (P less than .05). For patients with classical stage I disease, the relapse-free actuarial survival rate was 98%; for patients with anaplastic stage I disease, it was 64% (P less than .02). For the classical stage II disease group, the relapse-free actuarial survival rate was 84% and for the anaplastic stage II disease group, 75% (P less than .70). Four patients in the classical group (6%) had relapses; of these, one patient had local recurrence of tumor, and three had distant metastases. In the anaplastic group, four patients (21%) had relapses; two patients had local recurrence of tumor, and two had distant metastases. Therefore the data suggest a difference in survival and relapse rates between classical and anaplastic seminoma. 相似文献
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Mel'nikova VI Lavrent'eva AV Kudrin VS Raevskii KS Ugryumov MV 《Neuroscience and behavioral physiology》2005,35(8):809-813
The aim of the present work was to verify the hypothesis that non-dopaminergic neurons expressing individual complementary dopamine synthesis enzymes can perform the co-located synthesis of dopamine. According to this hypothesis, neurons expressing tyrosine hydroxylase use L-tyrosine for the synthesis of L-dihydroxyphenylalanine (L-DOPA), which then enters neurons expressing aromatic amino acid decarboxylase, which converts L-DOPA to dopamine. Experiments were performed using the mediobasal hypothalamus of rat fetuses, which mostly contains single-enzyme neurons (>99%) and occasional double-enzyme neurons (<1%). Controls were obtained from the fetal substantia nigra, which is enriched with dopaminergic neurons. High-performance liquid chromatography was used to measure levels of dopamine and L-DOPA in cell extracts and the incubation medium after incubation in the presence and absence of exogenous L-tyrosine. Addition of L-tyrosine to the medium led to increases in the level of synthesis and release of L-DOPA in the mediobasal hypothalamus and substantia nigra. In addition, L-tyrosine increased dopamine synthesis in the substantia nigra and decreased dopamine synthesis in the mediobasal hypothalamus. This regional difference in levels of dopamine synthesis is probably due to inhibition of the uptake of L-DOPA from the intercellular medium by neurons in the mediobasal hypothalamus containing aromatic amino acid decarboxylase, due to the competitive binding of the L-DOPA transporter by L-tyrosine. Thus, these results provide the first evidence for the co-located synthesis of dopamine by non-dopaminergic neurons expressing single complementary enzymes involved in the synthesis of this neurotransmitter.__________Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 90, No. 7, pp. 825–832, July, 2004. 相似文献
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Uvarov AV Kudrin VS Malikova LA Narevich VB Galenko-Yaroshevskii PA 《Bulletin of experimental biology and medicine》2000,129(5):460-462
The effect of cyclic GABA derivative TZ-146 on the content of catecholamines, serotonin, their metabolites, and neurotransmitter
amino acids in rat hypothalamus and brain stem was studied by high-performance liquid chromatography with electrochemical
detection. Opposite changes in the content of homovanillic acid, aspartate, glutamate, and glycine in the examined structures
were accompanied by inhibition of dopamine metabolism. Possible participation of cerebral glutamatergic system in the effect
of TZ-146 is discussed.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 5, pp. 544–546, May, 2000 相似文献
7.
Renal transplant (RT) is now a therapy of choice for end stage renal disease (ESRD). The Nephrology Unit, Asvini started functioning in Dec 90 and to date 1298 sittings of hemodialysis have been given to 45 patients. Of these, 35 were in ESRD and 11 patients underwent renal transplantation at this hospital during the period Jan 91 – Dec 93. One patient expired after 18 months of transplantation due to infection. Early experience in screening patients for RT, use of immunosuppression, management of rejection episodes and protocol are presented with special emphasis on its relevance to the Armed Forces.KEY WORDS: Transplantation, Renal Failure, Immunosuppression, Rejection 相似文献
8.
The paper deals with the results and efficiency of organizing emergency medical aid to victims in railway accidents, crashes, and other emergencies in the past years. It presents the data of researches, which characterizes the specific features of railway injury, which should be taken into account in planning and organizing a medical aid to suffered passengers and railway workers. The authors have developed and proposed guidelines for improving health care to emergency victims by railway therapeutical and prophylactic and sanitary facilities. 相似文献
9.
Longitudinal Andhra Pradesh Eye Disease Study: rationale,study design and research methodology
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Rohit C Khanna MD Gudlavalleti VS Murthy MD Srinivas Marmamula PhD Asha Latha Mettla MSc Pyda Giridhar PhD Seema Banerjee BOpt Konegari Shekhar DOA Subhabrata Chakrabarti PhD Clare Gilbert FRCS Gullapalli N Rao MD Andhra Pradesh Eye Disease Study Group 《Clinical & experimental ophthalmology》2016,44(2):95-105
10.