全文获取类型
收费全文 | 639篇 |
免费 | 40篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 6篇 |
妇产科学 | 11篇 |
基础医学 | 57篇 |
口腔科学 | 4篇 |
临床医学 | 42篇 |
内科学 | 105篇 |
皮肤病学 | 11篇 |
神经病学 | 28篇 |
特种医学 | 63篇 |
外科学 | 193篇 |
综合类 | 6篇 |
预防医学 | 36篇 |
眼科学 | 15篇 |
药学 | 44篇 |
中国医学 | 1篇 |
肿瘤学 | 64篇 |
出版年
2021年 | 3篇 |
2020年 | 11篇 |
2019年 | 4篇 |
2018年 | 21篇 |
2017年 | 8篇 |
2016年 | 19篇 |
2015年 | 10篇 |
2014年 | 12篇 |
2013年 | 22篇 |
2012年 | 17篇 |
2011年 | 28篇 |
2010年 | 15篇 |
2009年 | 16篇 |
2008年 | 20篇 |
2007年 | 25篇 |
2006年 | 23篇 |
2005年 | 34篇 |
2004年 | 32篇 |
2003年 | 20篇 |
2002年 | 21篇 |
2001年 | 22篇 |
2000年 | 29篇 |
1999年 | 20篇 |
1998年 | 12篇 |
1997年 | 9篇 |
1996年 | 11篇 |
1995年 | 7篇 |
1994年 | 5篇 |
1993年 | 11篇 |
1992年 | 19篇 |
1991年 | 16篇 |
1990年 | 21篇 |
1989年 | 13篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 15篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1980年 | 5篇 |
1979年 | 6篇 |
1978年 | 9篇 |
1977年 | 4篇 |
1974年 | 3篇 |
1973年 | 8篇 |
1970年 | 4篇 |
1967年 | 2篇 |
1934年 | 2篇 |
1933年 | 2篇 |
排序方式: 共有686条查询结果,搜索用时 15 毫秒
1.
B Gerdts AFPM Vloemans RW Kreis 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):781-788
BACKGROUND: Toxic epidermal necrolysis (TEN) is a severe and potentially fatal drug reaction characterized by an extensive skin rash with blisters and exfoliation, frequently accompanied by mucositis. The wounds caused by TEN are similar to second-degree burns and severe cases may involve large areas of skin loss. OBJECTIVES: Analysis of our results in patients with TEN and evaluation of the variety of therapeutic interventions that has been studied and suggested in TEN. PATIENTS/METHODS: Retrospective analysis of 19 consecutive patients with TEN treated in our burns centre between 1989 and 2004. RESULTS: Immediate withdrawal of any potentially fatal drug, maximum supportive care, and a restricted and tailored antibiotic, medical and surgical treatment regimen confined mortality to 21%, whereas prognosis scores like APACHE II and SCORTEN predicted mortality of 22 and 30%, respectively. A positive contribution of selective digestive decontamination is suggested but has yet to be established. CONCLUSIONS: Because of a potentially fatal outcome, fast referral of a patient suspected of TEN to a specialized centre (mostly a burns unit or specialized dermatology centre) for expert wound management and tailored comprehensive care is strongly advised and contributes to survival. 相似文献
2.
Corticosteroid inhibition of the OKT3-induced cytokine-related syndrome--dosage and kinetics prerequisites 总被引:2,自引:0,他引:2
The data presented extend to a larger series of 27 consecutive renal allograft recipients treated prophylactically with OKT3 our previous observation that the acute OKT3-induced clinical syndrome is related to massive release in the circulation of some cytokines, among which are tumor necrosis factor and interferon gamma. In addition, a pilot randomized study was set up including 12 consecutive patients receiving high-dose corticosteroid treatment (0.5 g solumedrol) either before or at the same time as the first OKT3 injection. Results confirm that when corticosteroids are given in sufficient amount and, importantly, 1 hr before the first OKT3 injection, they significantly decrease the release of both tumor necrosis factor and interferon gamma. In addition, the pretreatment with corticosteroids may totally abolish the IL-2 release induced by OKT3. Given the key role the massive although transient cytokine release plays in determining the OKT3-induced acute syndrome, these results provide the biological basis supporting a precise kinetics of administration of high-dose corticosteroids to better decrease the severity of the clinical reaction. 相似文献
3.
Norbert Boos Daniel Dreier Esther Hilfiker Volker Schade Roland Kreis Josef Hora Max Aebi Chris Boesch 《Journal of orthopaedic research》1997,15(1):141-149
The purpose of this investigation was to determine differences in tissue composition of symptomatic and asymptomatic disc herniations as reflected in T1 and T2 relaxation times (quantitative magnetic resonance investigation of the lumber spine. The longitudinal and transverse magnetic rlaxation times (T1 and T2, respectively) were calculated from a set of 20 images obtained with five single-slice/multi-echo sequences at different repetition time values on a commercial whole-body system (1.5 T). Twenty-two symptomatic and asymptomatic disc herniations could be matched according to age, gender, disc level, and the extent of herniation (protrusion or extrusion) and were compared with regard to T1 and T2 relaxation times. Symptomatic disc herniations exhibited significantly (pT1 < 0.04 and pT2 < 0.003) shorter T1(ΔT1:–182.1 milliseconds, ?15%) and T2(ΔT2: ?11.0 milliseconds, ?21%) relaxation times than matched asymptomatic herniations. Symptomatic disc herniations also exhibited more advanced disc degeneration as graded by Pearce's criteria (p < 0.01). These results suggest that symptomatic and morphologically matched asymptomatic disc herniations differ with regard to disc matrix composition. 相似文献
4.
In patients with histologically confirmed prostate cancer, oestrogen priming with diethylstilboestrol (DES) (3 mg/day) for 4 weeks prior to the first injection of the LHRH agonist Zoladex (3.6 mg depot form) prevented any rise in the serum testosterone concentration. In contrast, in the groups pre-treated with DES, the first, but not subsequent, injections with Zoladex were associated with a marked surge in luteinising hormone. Treatment with DES beyond the time of the first administration of Zoladex did not provide further endocrinological advantage. Oestrogen priming for 1 month prior to treatment with Zoladex may prevent an exacerbation of signs and symptoms of prostate cancer. 相似文献
5.
Complementation of snf1, a mutation affecting global regulation of carbon metabolism in yeast, by a plant protein kinase cDNA. 总被引:20,自引:0,他引:20
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
6.
Ross BD; Jacobson S; Villamil F; Korula J; Kreis R; Ernst T; Shonk T; Moats RA 《Radiology》1994,193(2):457
7.
Jonathan H. Marsh Willi Kreis Barbara Barile Silvia Akerman Philip Schulman Steven L. Allen Linda C. DeMarco Michael W. Schuster Daniel R. Budman 《Cancer chemotherapy and pharmacology》1993,31(6):481-484
Summary Eight patients, of whom four had acute myeloid leukemia (AML) and four had chronic myeloid leukemia (CML) blast crisis, were treated with a combination of cytosine arabinoside (ARA-C: 1,600 mg/m2 in three patients, 1,200 mg/m2 in five patients), tetrahydrouridine (THU: 2,800 mg/m2 in two patients, 2,646 mg/m2 in one patient, 2,100 mg/m2 in five patients), and carboplatin (900 mg/m2 in four patients, 720 mg/m2 in one patient, 450 mg/m2 in three patients). As a result of this treatment, five of the eight patients became aplastic. Two of the four patients with CML blast crisis reverted to the chronic phase and two of the four patients with acute nonlymphocytic leukemia (ANLL) attained a remission (one partial remission and one complete remission). The major toxicities included myelosuppression, unacceptable hepatotoxicity, and diarrhea. Pharmacokinetics studies revealed that the addition of carboplatin did not significantly change the disposition of ARA-C. ARA-C levels were not significantly changed in comparison with those obtained in a prior study of ARA-C with THU (ARA-C plasma levels at 3 h, 2630±1170 ng/ml).Supported by the Don Monti Memorial Research Foundation 相似文献
8.
Suspension-cultured DIGITALIS LANATA cells, known to form beta-methyldigoxin from beta-methyldigitoxin without any by-products, were not able to 12beta-hydroxylate digitoxin efficiently when cultivated in the cell culture medium devised by Murashige and Skoog. Most of the substrate added was merely glucosylated at its 16'-O-position leading to purpureaglycoside A as the main biotransformation product after 9 days of incubation. An 8% glucose solution (pH 5.5) turned out to be a suitable production medium for an efficient 12beta-hydroxylation of digitoxin. A two-stage procedure was developed in which DIGITALIS cells were grown in a modified Murashige and Skoog medium for 10 days and then transferred into 8% glucose medium. With regard to an effective 12beta-hydroxylation of digitoxin, maximum productivity was achieved when the cell line K 3 OHD was used with an initial cell density of about 20%. The substrate was added in one batch (190 mg digitoxin per flask, i.e. 0.5 gl (-1)) 3 days after transfer of cells to production medium. Under these conditions all of the digitoxin added was biotransformed within 12 days of incubation yielding the main product deacetyllanatoside C (88%) together with purpureaglycoside A (12%) both of which accumulated in the cells. 相似文献
9.
10.
C. Hennequin B. Page P. Roux C. Legendre H. Kreis 《European journal of clinical microbiology & infectious diseases》1995,14(2):122-126
The charts for seven renal transplant recipients who developedPneumocystis carinii pneumonia were reviewed. They included six men and one woman transplanted a mean of 150 days before the diagnosis of this infection. Six presented at least one episode of acute graft rejection. Cytomegalovirus pneumonia was diagnosed in six of the patients. All patients were treated with cotrimoxazole. Global mortality was 43 %. In additional to the classic hypothesis of latentPneumocystis carinii reactivation in immunocompromised hosts, this and previous reports of outbreaks strongly suggest either a person-to-person transmission or acquisition from the environment. Molecular typing of isolates could be of value in identifying the source of such outbreaks. Chemoprophylaxis should be more systematically administered to renal transplant patients, co-trimoxazole being the drug of choice. 相似文献