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排序方式: 共有131条查询结果,搜索用时 15 毫秒
1.
Hiroyoshi Machida Yoko Shibata Sumito Inoue Akira Igarashi Yoshikane Tokairin Keiko Yamauchi Tomomi Kimura Kento Sato Hiroshi Nakano Michiko Nishiwaki Maki Kobayashi Sujeong Yang Yukihiro Minegishi Kodai Furuyama Tomoka Yamamoto Tetsu Watanabe Tsuneo Konta Yoshiyuki Ueno Isao Kubota 《Respiratory investigation》2018,56(1):34-39
Background
Diabetes has been reported as a comorbidity of chronic obstructive pulmonary disease (COPD) in Western countries, but it has not been demonstrated in epidemiological reports in Japan. The purpose of this study was to clarify whether the relationship between airflow obstruction and diabetes can be confirmed in a Japanese general population.Methods
From 2004 to 2006, blood sampling and pulmonary function tests were performed on 3045 people over the age of 40 years in annual health check-ups held in Takahata, Yamagata Prefecture, Japan. Pulmonary function was re-evaluated in 2009 and 2011.Results
The prevalence of diabetes did not differ between subjects with and without airflow obstruction. Furthermore, although body mass index decreased, no increase in the prevalence of diabetes was observed with the progression of airflow obstruction. The annual changes in forced expiration volume in 1 s (FEV1) did not differ depending on the presence or absence of diabetes in the study population.Conclusion
There was no difference in the prevalence of diabetes between subjects with airflow obstruction and those without. As patients with COPD in Japan are thinner than in the West, diabetes may not be a common comorbidity in Japanese patients with COPD. 相似文献2.
By introducing bulky 2-phenylethyl groups into sulfur-rich electron acceptors, 5,5′-bithiazolidinylidene-2,2′-dione-4,4′-dithione and 5,5′-bithiazolidinylidene-2,4,2′,4′-tetrathione, electron transport with the mobility of 0.27 cm2 V−1 s−1 with ambient and long-term stability is achieved in thin-film transistors. Bulky groups destroy the intermolecular S–S network, but the long-term transistor stability is maintained. Here, benzyl groups realize one-dimensional stacking structures, whereas 2-phenylethyl groups lead to herringbone structures.Performance and long-term air stability of birhodanine-based n-channel transistors are improved by introducing phenylethyl moieties. 相似文献
3.
Kodai Abe Minoru Kitago Yohei Masugi Eisuke Iwasaki Hiroshi Yagi Yuta Abe Yasushi Hasegawa Seiichiro Fukuhara Shutaro Hori Masayuki Tanaka Yutaka Nakano Takahiro Yokose Gaku Shimane Michiie Sakamoto Yuko Kitagawa 《Pancreatology》2021,21(4):755-762
Background/ObjectivesAccording to the revised international intraductal papillary mucinous neoplasm (IPMN) guidelines (2017), the indication for surgery is based on risk classification. However, some IPMNs with high-risk stigmata (HRS) can be observed for long periods without resection. Hence, we need to reconsider the risk stratification, and this study aimed to propose a novel risk stratification for HRS-IPMNs.MethodsWe enrolled 328 patients diagnosed with IPMN using endoscopic ultrasound between 2012 and 2019. We compared clinicopathological features between HRS and worrisome features (WF) and evaluated outcomes of HRS-IPMN.ResultsFifty-three patients (HRS 38, WF 15) underwent resection at initial diagnosis and 275 patients were observed. Following observation for 30 months, 22 patients (17 HRS, 5 WF) underwent resection. Analysis of resected IPMNs (n = 75) revealed that HRS had dominantly pancreatobiliary mucin subtype. Pancreatobiliary-type IPMN had larger nodule sizes and lymphatic invasion and high recurrence with poor prognosis. Seventy-four patients were diagnosed with HRS, 55 underwent resection, and 19 continue to be observed. The resected group had larger nodule sizes (median 8 mm vs. 5 mm; P = 0.060), whereas the observed group had more main pancreatic duct (MPD) dilation (median 10 mm vs. 5 mm; P = 0.005). In the resected HRS group, only patients with MPD dilation ≥10 mm (n = 10) had no recurrence but had a favorable prognosis compared with those nodule size ≥5 mm (n = 45).ConclusionsLarge nodule size may be associated with pancreatobiliary subtype and poor prognosis; however, patients with MPD dilation ≥10 mm with nodule size <5 mm did not require resection. 相似文献
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Second Hepatic Resection for Recurrent Hepatocellular Carcinoma in Patients with Chronic Hepatitis C
Kubo S Takemura S Uenishi T Yamamoto T Ohba K Ogawa M Hai S Ichikawa T Kodai S Shinkawa H Tanaka H 《World journal of surgery》2008,32(4):632-638
Background Although a second hepatic resection (SHR) for recurrent hepatocellular carcinoma (HCC) is widely accepted, the indications
for SHR have not been established. The risk factors for HCC recurrence after SHR were evaluated to investigate the indications
for SHR.
Methods Subjects included 51 patients who underwent a second hepatic resection for recurrence of HCV-related HCC. Sixteen patients
received interferon therapy before or after the first operation. Six patients attained a sustained viral response (SVR) that
was defined as return of the alanine aminotransferase (ALT) activity to within the reference range and no detectable serum
HCV RNA for at least 1 year after interferon therapy. A biochemical response (BR), defined as a normalized ALT activity for
at least 1 year after interferon therapy with or without the transient disappearance of serum HCV RNA, was attained in three
patients. The other seven patients were defined as the nonresponse (NR) group.
Results By univariate analysis, NR and lack of interferon therapy, high indocyanine green retention rate at 15 min (ICGR15), high
aspartate aminotransferase activity, high ALT activity, large tumor, and multiple tumors were risk factors for HCC recurrence
after SHR. By multivariate analysis, NR and lack of interferon therapy, high ICGR15, large tumor, and multiple tumors were
independent risk factors.
Conclusions Patients in whom active hepatitis has been controlled by interferon therapy are the best candidates for SHR. Interferon therapy
should be recommended in patients undergoing resection of an HCV-related HCC because SHR can prolong life in SVR and BR patients. 相似文献
7.
8.
Risk factors for massive blood loss during liver resection for hepatocellular carcinoma in patients with cirrhosis 总被引:1,自引:0,他引:1
Kubo S Takemura S Yamamoto S Hai S Ichikawa T Kodai S Hiroji S Shuto T Hirohashi K Tanaka H 《Hepato-gastroenterology》2007,54(75):830-833
BACKGROUND/AIMS: Liver resection for hepatocellular carcinoma in patients with cirrhosis carries risk of major hemorrhage and sometimes requires blood transfusion. We investigated risk factors for massive blood loss during liver resection and indications for storing blood for autologous intraoperative transfusion. METHODOLOGY: We analyzed clinical records of 100 patients with cirrhosis who underwent liver resection for hepatocellular carcinoma. Autologous blood was stored preoperatively for 19 patients. RESULTS: Intraoperative blood loss ranged from 5 to 3000 mL (mean, 640). Liver resection was performed without transfusion in 67 patients and with autologous blood storage in 17 patients not receiving homologous blood. In the other 16 patients, homologous blood was transfused. Univariate analysis identified youth, large tumors (> 4cm), major hepatectomy, portal tumor involvement, hepatic vein involvement, and prolonged operation time as risk factors for massive blood loss; multivariate analysis identified portal involvement and hepatic vein involvement as independent risk factors. Blood loss exceeded 1000 mL in the 4 transfused group B patients and 3 of the 4 patients had hepatic vein involvement. CONCLUSIONS: Portal involvement and hepatic vein involvement were risk factors for massive blood loss during liver resection for hepatocellular carcinoma in patients with cirrhosis. Autologous blood storage is indicated in patients with such risk factors. 相似文献
9.
Ono Ryohei Iwahana Togo Toriumi Shuji Aoki Kaoruko Kato Hirotoshi Kato Kodai Yasui Masahiro Nakagawa Yuzuho Furuta Shunsuke Nakajima Hiroshi Kobayashi Yoshio 《Clinical rheumatology》2023,42(9):2507-2514
Clinical Rheumatology - Myocarditis has been reported as a life-threatening complication of adult-onset Still’s disease (AOSD), but fulminant myocarditis with AOSD is very rare. We hereby... 相似文献