全文获取类型
收费全文 | 940篇 |
免费 | 54篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 33篇 |
妇产科学 | 6篇 |
基础医学 | 94篇 |
口腔科学 | 16篇 |
临床医学 | 81篇 |
内科学 | 200篇 |
皮肤病学 | 13篇 |
神经病学 | 35篇 |
特种医学 | 162篇 |
外科学 | 125篇 |
综合类 | 32篇 |
预防医学 | 29篇 |
眼科学 | 10篇 |
药学 | 85篇 |
中国医学 | 7篇 |
肿瘤学 | 72篇 |
出版年
2023年 | 8篇 |
2022年 | 12篇 |
2021年 | 16篇 |
2020年 | 6篇 |
2019年 | 18篇 |
2018年 | 26篇 |
2017年 | 7篇 |
2016年 | 29篇 |
2015年 | 54篇 |
2014年 | 23篇 |
2013年 | 33篇 |
2012年 | 33篇 |
2011年 | 35篇 |
2010年 | 34篇 |
2009年 | 33篇 |
2008年 | 29篇 |
2007年 | 19篇 |
2006年 | 21篇 |
2005年 | 22篇 |
2004年 | 19篇 |
2003年 | 17篇 |
2002年 | 20篇 |
2001年 | 20篇 |
2000年 | 18篇 |
1999年 | 15篇 |
1998年 | 25篇 |
1997年 | 42篇 |
1996年 | 33篇 |
1995年 | 27篇 |
1994年 | 25篇 |
1993年 | 22篇 |
1992年 | 12篇 |
1991年 | 12篇 |
1990年 | 16篇 |
1989年 | 34篇 |
1988年 | 25篇 |
1987年 | 27篇 |
1986年 | 26篇 |
1985年 | 15篇 |
1984年 | 10篇 |
1983年 | 13篇 |
1982年 | 9篇 |
1981年 | 9篇 |
1980年 | 9篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1976年 | 11篇 |
1974年 | 4篇 |
1972年 | 3篇 |
1970年 | 3篇 |
排序方式: 共有1005条查询结果,搜索用时 15 毫秒
1.
Keiko Goto Yutaka Fujiwara Takeshi Isobe Naoko Chayahara Naomi Kiyota Toru Mukohara Yukari Tsubata Takamasa Hotta Kenji Tamura Noboru Yamamoto Hironobu Minami 《Cancer science》2019,110(6):1987-1994
Although dose reduction of S‐1 is recommended for patients with impaired renal function, dose modification for such patients has not been prospectively evaluated. The aim of the present study was to investigate the pharmacokinetic parameters of 5‐fluorouracil, 5‐chloro‐2,4 dihydroxypyridine and oteracil potassium, and to review the recommended dose modification of S‐1 in patients with renal impairment. We classified patients receiving S‐1 into 4 groups according to their renal function, as measured using the Japanese estimated glomerular filtration rate (eGFR) equation. The daily S‐1 dose was adjusted based on the patient's eGFR and body surface area. Blood samples were collected for pharmacokinetic analysis. A total of 33 patients were enrolled and classified into 4 groups as follows: 10 patients in cohort 1 (eGFR ≥ 80 mL/min/1.73 m2), 10 patients in cohort 2 (eGFR = 50‐79 mL/min/1.73 m2), 10 patients in cohort 3 (eGFR = 30‐49 mL/min/1.73 m2), and 3 patients in cohort 4 (eGFR < 30 mL/min/1.73 m2). Those in cohorts 3 and 4 treated with an adjusted dose of S‐1 showed a similar area under the curve for 5‐fluorouracil (941.9 ± 275.6 and 1043.5 ± 224.8 ng/mL, respectively) compared with cohort 2 (1034.9 ± 414.3 ng/mL). Notably, while there was a statistically significant difference between cohort 1 (689.6 ± 208.8 ng/mL) and 2 (P = 0.0474) treated with an equal dose of S‐1, there was no significant difference observed in the toxicity profiles of the cohorts. In conclusion, dose adjustment of S‐1 in patients with impaired renal function using eGFR is appropriate and safe. 相似文献
2.
3.
4.
K Matsuda Y Kiyota N Tamura M Takahashi H Miki H Suzuki Y Nakagawa Y Satou M Noda T Nakamura 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(5):389-391
A 64-year-old man, who had an aneurysm of aortic arch associated with the aberrant right subclavian artery, was treated successfully. He was pointed out to have an aneurysm of aortic arch three years ago. Three years later angiograms and computed tomography revealed that it became larger compared with the initial finding. He underwent a replacement of the aortic arch using a woven Dacron graft under open distal method. Aberrant subclavian artery was not involved in the aneurysm. But because the left subclavian artery was involved in it, a woven Dacron graft was interposed between the ascending aorta and left subclavian artery. Postoperative course was uneventful and there were no complications. 相似文献
5.
Hausegger KA; Cragg AH; Lammer J; Lafer M; Fluckiger F; Klein GE; Sternthal MH; Pilger E 《Radiology》1994,190(1):199
6.
7.
8.
9.
10.